全文获取类型
收费全文 | 432篇 |
免费 | 23篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 8篇 |
妇产科学 | 6篇 |
基础医学 | 61篇 |
口腔科学 | 8篇 |
临床医学 | 55篇 |
内科学 | 73篇 |
皮肤病学 | 14篇 |
神经病学 | 34篇 |
特种医学 | 9篇 |
外科学 | 55篇 |
综合类 | 7篇 |
预防医学 | 32篇 |
眼科学 | 48篇 |
药学 | 24篇 |
中国医学 | 1篇 |
肿瘤学 | 23篇 |
出版年
2024年 | 1篇 |
2023年 | 5篇 |
2022年 | 23篇 |
2021年 | 29篇 |
2020年 | 10篇 |
2019年 | 20篇 |
2018年 | 16篇 |
2017年 | 9篇 |
2016年 | 24篇 |
2015年 | 17篇 |
2014年 | 28篇 |
2013年 | 28篇 |
2012年 | 44篇 |
2011年 | 49篇 |
2010年 | 15篇 |
2009年 | 19篇 |
2008年 | 16篇 |
2007年 | 17篇 |
2006年 | 18篇 |
2005年 | 16篇 |
2004年 | 12篇 |
2003年 | 12篇 |
2002年 | 6篇 |
2001年 | 4篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1995年 | 1篇 |
1992年 | 1篇 |
1989年 | 2篇 |
1986年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1957年 | 1篇 |
1956年 | 1篇 |
1954年 | 1篇 |
1947年 | 1篇 |
1927年 | 1篇 |
排序方式: 共有460条查询结果,搜索用时 15 毫秒
1.
With regard to cadmium toxicity, Drosophila strains v;bw and Austin represent extremes in resistance and sensitivity, respectively. Both strains produced metallothionein (MT) in response to Cd ions in their diet. Austin produced more metallothionein than v;bw at Cd ion levels below 0.2 mM, when both strains were allowed lifetime development on Cd2+-containing media. When the rate of MT appearance was measured for 4 days in young adults the results showed no clear trend with time within a strain or between strains. The plot of LC50 vs. MT levels for identical developmental conditions revealed that for v;bw small increases in MT corresponded to large increases in resistance whereas for the sensitive Austin even large increases in MT had comparatively little effect on increasing LC50. Results given here suggest that differences in total MT content do not explain the genetically demonstrable difference in Cd2+-resistance between v;bw and Austin. However, since two MT genes are identified in Drosophila, differences in resistance could be reflective of greater relative amounts of one "more important" MT in the resistant fly. 相似文献
2.
M I Steele T L Kuhls K Nida C S Meka I M Halabi D A Mosier W Elliott D L Crawford R A Greenfield 《Infection and immunity》1995,63(10):3840-3845
3.
Fatima Nida Massaad Elie Hadzipasic Muhamed Shankar Ganesh M. Shin John H. 《Neurosurgical review》2021,44(3):1357-1370
Neurosurgical Review - Treatment of osteoporosis with medications like teriparatide, a parathyroid hormone, is known to improve bone density and reduce the risk of osteoporotic vertebral fractures.... 相似文献
4.
İpek Ulu Yasemin Çekmez Şule Yıldırım Köpük Nida Özer Eser Evrim Yoğurtçuoğlu Pınar Anğın 《The journal of maternal-fetal & neonatal medicine》2019,32(15):2543-2546
Purpose: The aim of the study was to investigate whether maternal serum TSP-1 level was associated with PE.Materials and methods: In our case control study, 84 pregnant women in the third trimester were included. Forty-one of them were healthy and 43 of them were with the diagnosis of PE. The diagnosis was based on the definitions of the National High Blood Pressure Education Program working Group on High Blood Pressure in Pregnancy. Preeclamptic patients were divided into two subgroups as mild and severe. Blood pressure (BP) of pregnant women were obtained in left-side lying position using a mercury sphygmomanometer after at least 10 minutes of rest. Ten milliliters of venous blood was taken from every pregnant women and dispensed into lithium heparin and serum was obtained. Samples were stored at ?80?°C until analyzed. Serum TSP-1 level was measured using enzyme-linked immunosorbent assay (ELISA). All tests were two-tailed and p < .05 was considered to be statistically significant.Results: TSP-1 level was significantly lower in PE group than in controls (p?=?.003). Platelet counts were similar in two groups (p = .26). TSP-1 levels were significantly lower in severe PE than in mild PE cases. According to the subgroup analysis, TSP-1 level was found significantly lower in severe preeclampsia group compared to control group (p = .015).Conclusions: In light of the association between endothelial dysfunction and preeclampsia, we claim that lower levels of TSP-1 which is released mostly from endothelial cells seem to reflect disease severity in PE. Our study reveals that maternal serum TSP-1 levels decrease in pregnant women presenting with PE and TSP-1 may be a new biomarker for the detection of PE and even severity of it. Further studies especially prospective ones with greater numbers of cases are needed. 相似文献
5.
6.
7.
Marib Akanda Shilpa Kodati Alexander Melamud H. Nida Sen 《Ocular immunology and inflammation》2018,26(5):671-676
Dengue fever can cause ocular complications that may not be easily identified during a regular eye examination. A high degree of suspicion and multimodal imaging will help characterize the lesions during acute stages of the infection. 相似文献
8.
9.
Jargalsaikhan Dagvadorj Karolina Mikulska-Ruminska Gantsetseg Tumurkhuu Rojo A. Ratsimandresy Jessica Carriere Allen M. Andres Stefanie Marek-Iannucci Yang Song Shuang Chen Malcolm Lane Andrea Dorfleutner Roberta A. Gottlieb Christian Stehlik Suzanne Cassel Fayyaz S. Sutterwala Ivet Bahar Timothy R. Crother Moshe Arditi 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(1)
10.
Lars Bendtsen Simona Sacco Messoud Ashina Dimos Mitsikostas Fayyaz Ahmed Patricia Pozo-Rosich Paolo Martelletti 《The journal of headache and pain》2018,19(1):91
OnabotulinumtoxinA is being increasingly used in the management of chronic migraine (CM). Treatment with onabotulinumtoxinA poses challenges compared with traditional therapy with orally administered preventatives. The European Headache Federation identified an expert group that was asked to develop the present guideline to provide recommendations for the use of onabotulinumtoxinA in CM. The expert group recommend onabotulinumtoxinA as an effective and well-tolerated treatment of CM. Patients should preferably have tried two to three other migraine prophylactics before start of onabotulinumtoxinA. Patients with medication overuse should be withdrawn from the overused medication before initiation of onabotulinumtoxinA if feasible, if not onabotulinumtoxinA can be initiated from the start or before withdrawal. OnabotulinumtoxinA should be administered according to the PREEMPT injection protocol, i.e. injecting 155 U–195 U to 31–39 sites every 12-weeks. We recommend that patients are defined as non-responders, if they have less than 30% reduction in headache days per month during treatment with onabotulinumtoxinA. However other factors such as headache intensity, disability and patient preferences should also be considered when evaluating response. Treatment should be stopped, if the patient does not respond to the first two to three treatment cycles. Response to continued treatment with onabotulinumtoxinA should be evaluated by comparing the 4 weeks before with the 4 weeks after each treatment cycle. It is recommended that treatment is stopped in patients with a reduction to less than 10 headache days per month for 3 months and that patients are re-evaluated 4–5 months after stopping onabotulinumtoxinA to make sure that the patient has not returned to CM. Questions regarding efficacy and tolerability of onabotulinumtoxinA could be answered on the basis of scientific evidence. The other recommendations were mainly based on expert opinion. Future research on the treatment of CM with onabotulinumtoxinA may further improve the management of this highly disabling disorder. 相似文献