全文获取类型
收费全文 | 405篇 |
免费 | 30篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 8篇 |
基础医学 | 66篇 |
口腔科学 | 1篇 |
临床医学 | 29篇 |
内科学 | 113篇 |
皮肤病学 | 3篇 |
神经病学 | 38篇 |
特种医学 | 4篇 |
外科学 | 42篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 53篇 |
眼科学 | 6篇 |
药学 | 46篇 |
中国医学 | 4篇 |
肿瘤学 | 16篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 13篇 |
2021年 | 25篇 |
2020年 | 8篇 |
2019年 | 13篇 |
2018年 | 24篇 |
2017年 | 15篇 |
2016年 | 14篇 |
2015年 | 12篇 |
2014年 | 17篇 |
2013年 | 25篇 |
2012年 | 39篇 |
2011年 | 49篇 |
2010年 | 27篇 |
2009年 | 18篇 |
2008年 | 26篇 |
2007年 | 16篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 19篇 |
2003年 | 14篇 |
2002年 | 3篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1998年 | 2篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有435条查询结果,搜索用时 15 毫秒
1.
HCV-specific CD27- CD28- memory T cells are depleted in hepatitis C virus and Schistosoma mansoni co-infection 总被引:1,自引:0,他引:1 下载免费PDF全文
Factors that influence the generation and maintenance of memory CD8+ T cells are not fully understood. The homeostasis of memory T cells is highly dynamic and tightly regulated by various stimuli, including cytokines and antigen-major histocompatibility complex ligands. We characterized the hepatitis C virus (HCV)-specific CD8+ T-cell responses in a cohort of HCV-infected individuals with or without Schistosoma mansoni co-infection from Egypt. We observed a significantly decreased CD27- CD28- (late differentiated) memory T-cell population in the HCV co-infected individuals compared to those with HCV infection alone. In contrast, there was no significant difference in the CD27+ CD28+ (early differentiated) memory T cells between the two groups. Analysis of human cytomegalovirus-specific CD8+ T-cell responses in the same individuals failed to reveal a similar pattern of altered memory T-cell differentiation. Thus, S. mansoni co-infection targets a specific subset of memory CD8+ T cells in HCV infection. 相似文献
2.
People with vision loss sometimes experience visual hallucinations associated with Charles Bonnet syndrome. The appearance of these hallucinations often causes anxiety for the sufferer and can be difficult for the attending eye care professional to manage. A review of the literature highlighted a range of visual, pharmacological and social management regimes that may alleviate these hallucinations, albeit using small samples in uncontrolled trials. Eye care practitioners should be aware of methods of rehabilitation in Charles Bonnet syndrome that may lead to resolution of the visual hallucinations. 相似文献
3.
Methotrexate[MTX] is commonly employed as the initial DMARD used for treatment of Rheumatoid arthritis[RA]. We aimed to contribute to the safety profile of MTX by assessing its cumulative effect on renal filtration. Fifty two RA adult females with normal base-line serum creatinine and GFR at the initial diagnosis of the disease were included. Group-1[G1] included 30 patients[mean age 40.4 ± 4.4 years] on MTX and NSAIDS, while 22 RA patients[mean age 38.5 ± 8.2 years] who received NSAIDs only served as the control group[G2]. Renal function was assessed by GFR-measurement using Technetium diethylenetriamine-pentaacetic acid[Tc-99 m-DTPA] at the point of the study time corresponding to disease duration. 21/30[70%] in G1 showed reduced GFR compared to 6/22[27.3%] in G2[P0.007] with 3.3 ± 0.5% annual reduction of GFR. Reduced GFR in G1 showed significant negative correlation with age[r = ?0.396, P = 0.005], MTX-cumulative dose[r = ?0.263, P = 0.049], MTX-intake duration[r = ?0.293, P = 0.031] and NSAID-intake duration[r = ?0.344, P = 0.014]. Low dose MTX has a slow cumulative effect on renal filtration manifested by GFR reduction over time that could be monitored by Tc-99 m DTPA. 相似文献
4.
5.
6.
Tawandra L. Rowell-Cunsolo Betsy Szeto Charlotte McDonald Nabila El-Bassel 《Drugs (Abingdon, England)》2018,25(3):234-240
Aims: The number of drug-dependent individuals incarcerated in the USA is exceptionally high, and reportedly up to 60% of incarcerated Black Americans have a substance abuse disorder. The purpose of this study was to identify factors associated with return to illicit drug use post-incarceration.Methods: A cross-sectional study was conducted with 121 formerly incarcerated Black Americans in New York City to examine predictors of return to illicit drug use. Kaplan–Meier curves were generated on the outcome of time-to-drug use for various predictors and compared using the log-rank test. Cox proportional hazards models were used to identify significant predictors of return to illicit drug use post-incarceration.Findings: Approximately 83% (n?=?100) of the participants reported a history of illicit drug use, not including participants who have only used marijuana. Out of 121 participants, 36 (29.8%) had used drugs within 1?day after release. By 2 weeks post-release, half had used drugs. Gender and history of heroin use were significant predictors of time-to-drug use according to the log-rank test.Conclusions: The potential for immediate return to drug use among our sample suggests that discharge support programmes that focus specifically on healthy decision-making among women and heroin users are especially critical. 相似文献
7.
Farah Ahmad Syeda F. Kabir Nabila H. Purno Saima Islam Ophira Ginsburg 《Health care for women international》2017,38(4):334-343
In many low- and middle-income countries, breast cancer survival is low. Reasons for this are multifactorial, but delayed presentation for care is a common theme. In this survey study with 100 urban Bangladeshi women, we examined the role of socioeconomic and sociocultural factors on their likelihood to seek breast care from a family physician. In our multivariate model, a woman's age and education significantly predicted her likelihood to see a physician. Sociocultural aspects (e.g., concerns about time commitment of family members, personal household obligations) were significant at bivariate level. Findings are discussed in relation to practice, policy, and research. 相似文献
8.
Ezzeldeen S. El Denshary Mohammad A. Al-Gahazali Fathia A. Mannaa Hesham A. Salem Nabila S. Hassan Mosaad A. Abdel-Wahhab 《Experimental and toxicologic pathology》2012,64(7-8):753-760
Liver diseases are amongst the most serious health problems in the world today and hepatocellular carcinoma is one of the world's deadliest cancers. The aim of the current study was to evaluate the protective effect of sider honey and/or Korean ginseng extract (KGE) against carbon tetrachloride (CCl4)-induced hepato-nephrotoxicity in rat. Eighty male Sprague-Dawley (SD) rats were allocated into different groups and over a 4-week period, they orally received honey and/or KGE or were treated either with CCl4 alone (100 mg/kg b.w) or with CCl4 after a pretreatment period with honey, KGE or a combination of both. Clinical, clinico-pathological and histopathological evaluations were done and CCl4-treated groups were compared with rats receiving no treatment and with rats given honey, KGE or a combination of these substances. The results indicated that oral administration of CCl4 induced severe hepatic and kidney injury associated with oxidative stress. The combined treatment with CCl4 plus honey and/or KGE resulted in a significant improvement in all evaluated parameters. This improvement was prominent in the group receiving CCl4 after combined pretreatment with honey and KGE. Animals receiving honey and/or KGE (without CCl4-treatment) were comparable to the control untreated group. It could be concluded that honey and KGE protect SD rats against the severe CCl4-induced hepatic and renal toxic effects. Our results suggest that the protective activity of honey and KGE may have been related to their antioxidant properties. 相似文献
9.
Performance of the OptiMAL test for malaria diagnosis among suspected malaria patients at the rural health centers 总被引:3,自引:0,他引:3
Iqbal J Muneer A Khalid N Ahmed MA 《The American journal of tropical medicine and hygiene》2003,68(5):624-628
The OptiMAL test detects both Plasmodium falciparum and P. vivax malaria infections. In this study, we evaluated the performance of the OptiMAL test at the Basic Health Units (BHUs) and the District Health Quarter (DHQ) Center in rural villages of Punjab, Pakistan that provide minimal health services. Two sets of blood specimens obtained from 930 suspected malaria patients attending these BHUs were tested at BHUs and the DHQ Center by microscopy and the OptiMAL test. At the BHUs, 231 (25%) of the patients were positive by microscopy and 278 (30%) patients tested positive by the OptiMAL test. At the DHQ Center, microscopic analysis of a second set of specimens from the same patients confirmed the malaria infection in 386 (42%) patients and the OptiMAL test result was positive in 300 (32%) patients. To determine the performance of OptiMAL test at the BHUs and the DHQ Center, all data were compared with microscopy results obtained at the DHQ Center. The OptiMAL test results for P. falciparum at the BHUs were comparable to those of the OptiMAL test at the DHQ Center. However, the sensitivity, positive predictive value (PPV), and negative predictive value (NPV) of the OptiMAL test were considerably lower for P. vivax infections than for P. falciparum infections, irrespective of whether the test was performed at the BHUs or at the DHQ Center (P. falciparum: sensitivity = 78-85%, PPV = 89-97%, NPV = 96-98%; P. vivax: sensitivity = 61-76%, PPV = 88-95%, NPV = 90-93%). The OptiMAL test also detected a number of false-positive and false-negative results at both the BHUs and the DHQ Center. The false-positive results ranged from 1% to 2%; however, the number of false-negative results was much higher (BHUs: P. falciparum = 22%, P. vivax = 39%; DHQ Center: P. falciparum = 15%, P. vivax = 24%). In conclusion, these results, when combined with other advantages of the OptiMAL test, suggest that this test can be used by relatively inexperienced persons to diagnose malaria infection in rural areas where facilities for microscopy are not available. 相似文献
10.
Elizabeth R. Richens Azza Shaltout George M. Bahr Nabila Abdella Abdel K. Jayyab Muna Al-Saffar Kazem Behbehani 《Acta diabetologica》1989,26(2):115-122
Summary Insulin autoantibodies (IAAs) are associated with type I diabetes mellitus (DM) and have been suggested as predictive markers
of the disease. Using an ELISA assay, we have studied the prevalence of binding to human insulin in sera from an Arab type
I DM population and compared it with the prevalence in the family members (FMs) of the probands, in type II DM patients from
the same population, and in Arab control subjects. Significant levels of binding occurred in 11/16 (69%) of type I DM patients
and in 21/34 (62%) of their FMs, but in only 5/31 (16%) of type II DM patients and in 1/25 (4%) of control subjects. Within
families, there was homogeneity with regard to the level of insulin binding and the mean family levels correlated with those
of the proband (r=0.68, df=7, p=0.05). HLA-DR3 or -DR4 antigens occurred in 55/63 (87%) of type I DM patients and in 95/118
(81%) of their FMs. This was significantly higher (p<0.001) than in either type II DM patients (39/75, 52%) or in control
subjects (34/93, 37%). ICAs were present in significantly more (25/43, 58%) of type I DM patients than their FMs (3/82, 3%)
(p<0.001). They did not occur in either type II DM patients or in the control group. In conclusion, insulin binding occurred
in sera from both type I diabetic patients and their kindred, and hence did not appear to be specifically associated with
the development of clinical diabetes. 相似文献