全文获取类型
收费全文 | 13071篇 |
免费 | 836篇 |
国内免费 | 93篇 |
专业分类
耳鼻咽喉 | 93篇 |
儿科学 | 318篇 |
妇产科学 | 182篇 |
基础医学 | 1480篇 |
口腔科学 | 296篇 |
临床医学 | 1290篇 |
内科学 | 3208篇 |
皮肤病学 | 275篇 |
神经病学 | 663篇 |
特种医学 | 288篇 |
外国民族医学 | 4篇 |
外科学 | 2204篇 |
综合类 | 391篇 |
现状与发展 | 1篇 |
一般理论 | 7篇 |
预防医学 | 898篇 |
眼科学 | 251篇 |
药学 | 1229篇 |
中国医学 | 211篇 |
肿瘤学 | 711篇 |
出版年
2024年 | 18篇 |
2023年 | 251篇 |
2022年 | 669篇 |
2021年 | 920篇 |
2020年 | 530篇 |
2019年 | 649篇 |
2018年 | 632篇 |
2017年 | 428篇 |
2016年 | 486篇 |
2015年 | 524篇 |
2014年 | 625篇 |
2013年 | 752篇 |
2012年 | 1152篇 |
2011年 | 1117篇 |
2010年 | 555篇 |
2009年 | 476篇 |
2008年 | 727篇 |
2007年 | 622篇 |
2006年 | 578篇 |
2005年 | 540篇 |
2004年 | 425篇 |
2003年 | 376篇 |
2002年 | 257篇 |
2001年 | 61篇 |
2000年 | 53篇 |
1999年 | 54篇 |
1998年 | 49篇 |
1997年 | 28篇 |
1996年 | 30篇 |
1995年 | 28篇 |
1994年 | 28篇 |
1993年 | 31篇 |
1992年 | 23篇 |
1991年 | 12篇 |
1990年 | 22篇 |
1989年 | 29篇 |
1988年 | 22篇 |
1987年 | 25篇 |
1986年 | 13篇 |
1985年 | 12篇 |
1984年 | 15篇 |
1983年 | 17篇 |
1982年 | 21篇 |
1981年 | 24篇 |
1980年 | 10篇 |
1978年 | 9篇 |
1977年 | 11篇 |
1976年 | 7篇 |
1975年 | 8篇 |
1973年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
5.
6.
7.
Expression of TRIM22 mRNA in chronic hepatitis C patients treated with direct-acting antiviral drugs
Mariam Naveed Amjad Ali Nadeem Sheikh Shazia Rafique Muhammad Idrees 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2020,128(4):326-334
Hepatitis C is a global public health problem, and Pakistan is the second largest country in the globe with highest prevalence rate of hepatitis C virus (HCV). Until 2014, pegylated interferon (PEG-IFN) plus ribavirin (RBV) has been the standard therapy for HCV, however, owing to its adverse side effects and very low sustained virologic response (SVR) rates therapeutics trend is shifted toward direct-acting antivirals. Tripartite motif containing 22 (TRIM22) is a dynamic antiviral protein that can inhibit multiple viruses in vivo. Expression of TRIM22 mRNA has been linked to outcome of PEG-IFN and ribavirin therapy, where its higher expression leads to rapid virus clearance. However, in terms of therapy with direct-acting antiviral (DAA) or double DAA, impact of TRIM22 expression is largely unknown. These new drugs show more than 90% of SVR rates and lesser side effects and have proven to be better than IFN therapy. Endogenous IFN system suppresses various pathogens through the induction of antiviral effectors termed as interferon-stimulating genes (ISGs). We have studied the expression levels of one of these antiviral effectors, TRIM22 in response to sofosbuvir (SOF) and daclatasvir (DAC) in combination with RBV, using quantitative PCR in the peripheral blood mononuclear cells (PBMCs) of HCV-infected patients. We have observed sustained virus clearance in more than 90% of patients treated with DAA and double DAA and have seen the expression of TRIM22 to be higher in patients who attained SVR as compared to the untreated patients. We have also observed downregulation of TRIM22 in patients who failed to attain rapid virus clearance, and upregulation in those who achieved rapid clearance of virus. Genetic factors that determine the lower TRIM22 expression in these patients are needed to be explored that may also play a role in lower response to anti-HCV therapy. Endogenous IFN system and effects of antiviral proteins in response to DAA therapy is needed to be studied in order to better understand the host response toward these drugs to make them more effective. 相似文献
8.
Shakil Saba Muhammad Sajid Hamid Akash Kanwal Rehman Uzma Saleem Fareeha Fiayyaz Tanvir Ahmad 《Clinical and experimental pharmacology & physiology》2020,47(10):1682-1691
Arsenic (As) and cadmium (Cd) have recently emerged as major health concerns owing to their strong association with diabetes mellitus (DM). We aimed to investigate the heavy metals exposure towards incidence of DM at various enzymatic and hormonal levels. Additionally, association of As and Cd with Zinc (Zn, essential metal) was also evaluated. Spot urine samples were collected to assess As, Cd and Zn through ICP-OES. Serum was analyzed by assay method for fasting blood glucose, liver and renal function biomarkers. ELISA was performed to investigate the impact of heavy metals on HbA1c, α-amylase, DPP-IV, IGF-1, leptin, GSH, MDA, SOD, HDL, FFA, TG and interleukin (IL)-6. Association of heavy metals with DM was measured by odds ratio (OR) and level of significance was assessed by Chi-squared test. Unpaired student's t-test was used to compare DM-associated risk factors in heavy metals-exposed and unexposed participants. As and Cd were detectable in 75.4% and 83% participants with mean concentration of 75.5 ppb and 54.5 ppb, respectively. For As exposure, OR in the third quartile was maximum ie 1.34 (95% CI, 0.80 to 2.23), however the result was not statistically significant (P > .05). For Cd exposure, OR in the fourth quartile was considerably high, 1.62 (95% CI, 1.00 to 2.61), with a significant probability value (P < .05). Urinary Cd was negatively associated with Zn. As and Cd exposure increases the incidence of DM in the general population. Impaired hormonal and enzymatic levels in diabetic and non-diabetic exposed participants reflect the multiple organ damage by heavy metal exposure. 相似文献
9.
Sami Al-Said Ammar Ali Abdul Kader Alobaidy Emad Mojeeb Abdulla Al-Naimi Ahmed A Shokeir 《International journal of urology》2007,14(5):452-454
Xanthogranulomatous orchitis is an extremely rare inflammatory non-neoplastic destructive lesion of the testis. We report a 44-year-old man who presented with right scrotal swelling and two discharging sinuses. Testicular tumor markers were normal. Scrotal ultrasound showed heterogeneous testicular areas and irregular margin of the tunica. Surgical exploration revealed infected, unhealthy testicular tissue with necrosis and tumor-like lesion. Orchidectomy was done and histopathology showed xanthogranulomatous orchitis. 相似文献
10.
The records of 37 patients with liver injuries operated upon at the Ahmadu Bello University Teaching Hospital, Zaria, Nigeria from 1976 to 1987 were reviewed. There were 31 males and 6 females with a mean age of 22 years. Sixty-two per cent were due to blunt injury from road traffic accidents, 14 per cent were due to gunshot wounds and 5 per cent due to stab wounds as a result of assaults. Treatment with simple suture and drainage sufficed in 49 per cent; only 16 per cent required resection, packing and drainage. Associated injuries included long bone fractures and chest trauma. The most common complication was sepsis and the overall mortality was 19 per cent. 相似文献