全文获取类型
收费全文 | 10917篇 |
免费 | 812篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 247篇 |
儿科学 | 222篇 |
妇产科学 | 122篇 |
基础医学 | 1643篇 |
口腔科学 | 214篇 |
临床医学 | 898篇 |
内科学 | 2153篇 |
皮肤病学 | 108篇 |
神经病学 | 807篇 |
特种医学 | 317篇 |
外国民族医学 | 1篇 |
外科学 | 1915篇 |
综合类 | 74篇 |
一般理论 | 8篇 |
预防医学 | 827篇 |
眼科学 | 838篇 |
药学 | 622篇 |
中国医学 | 7篇 |
肿瘤学 | 746篇 |
出版年
2023年 | 159篇 |
2022年 | 171篇 |
2021年 | 336篇 |
2020年 | 258篇 |
2019年 | 365篇 |
2018年 | 340篇 |
2017年 | 295篇 |
2016年 | 305篇 |
2015年 | 306篇 |
2014年 | 432篇 |
2013年 | 542篇 |
2012年 | 758篇 |
2011年 | 723篇 |
2010年 | 428篇 |
2009年 | 416篇 |
2008年 | 643篇 |
2007年 | 634篇 |
2006年 | 553篇 |
2005年 | 508篇 |
2004年 | 475篇 |
2003年 | 459篇 |
2002年 | 424篇 |
2001年 | 181篇 |
2000年 | 167篇 |
1999年 | 144篇 |
1998年 | 106篇 |
1997年 | 72篇 |
1996年 | 69篇 |
1995年 | 78篇 |
1994年 | 61篇 |
1993年 | 44篇 |
1992年 | 82篇 |
1991年 | 83篇 |
1990年 | 64篇 |
1989年 | 57篇 |
1988年 | 68篇 |
1987年 | 56篇 |
1986年 | 53篇 |
1985年 | 56篇 |
1984年 | 35篇 |
1979年 | 31篇 |
1933年 | 31篇 |
1930年 | 34篇 |
1928年 | 33篇 |
1927年 | 33篇 |
1926年 | 34篇 |
1925年 | 41篇 |
1924年 | 37篇 |
1923年 | 29篇 |
1922年 | 30篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Tengzhi Liu Kathrine Røe Redalen Morten Karlsen 《Journal of labelled compounds & radiopharmaceuticals》2022,65(7):191-202
Cyclotron-produced copper-64 radioisotope tracers offer the possibility to perform both diagnostic investigation by positron emission tomography (PET) and radiotherapy by a theranostic approach with bifunctional chelators. The versatile chemical properties of copper add to the importance of this isotope in medicinal investigation. [64Cu][Cu (ATSM)] has shown to be a viable candidate for imaging of tumor hypoxia; a critical tumor microenvironment characteristic that typically signifies tumor progression and resistance to chemo-radiotherapy. Various production and radiosynthesis methods of [64Cu][Cu (ATSM)] exist in labs, but usually involved non-standardized equipment with varying production qualities and may not be easily implemented in wider hospital settings. [64Cu][Cu (ATSM)] was synthesized on a modified GE TRACERlab FXN automated synthesis module. End-of-synthesis (EOS) molar activity of [64Cu][Cu (ATSM)] was 2.2–5.5 Ci/μmol (HPLC), 2.2–2.6 Ci/μmol (ATSM-titration), and 3.0–4.4 Ci/μmol (ICP-MS). Radiochemical purity was determined to be >99% based on radio-HPLC. The final product maintained radiochemical purity after 20 h. We demonstrated a simple and feasible process development and quality control protocols for automated cyclotron production and synthesis of [64Cu][Cu (ATSM)] based on commercially distributed standardized synthesis modules suitable for PET imaging and theranostic studies. 相似文献
2.
3.
4.
5.
6.
Marie Warrer Petersen Tine Sylvest Meyhoff Marie Helleberg Maj-Brit Nørregaard Kjær Anders Granholm Carl Johan Steensen Hjortsø Thomas Steen Jensen Morten Hylander Møller Peter Buhl Hjortrup Mik Wetterslev Gitte Kingo Vesterlund Lene Russell Vibeke Lind Jørgensen Klaus Tjelle Thomas Benfield Charlotte Suppli Ulrik Anne Sofie Andreasen Thomas Mohr Morten H. Bestle Lone Musaeus Poulsen Mette Friberg Hitz Thomas Hildebrandt Lene Surland Knudsen Anders Møller Christoffer Grant Sølling Anne Craveiro Brøchner Bodil Steen Rasmussen Henrik Nielsen Steffen Christensen Thomas Strøm Maria Cronhjort Rebecka Rubenson Wahlin Stephan Jakob Luca Cioccari Balasubramanian Venkatesh Naomi Hammond Vivekanand Jha Sheila Nainan Myatra Christian Gluud Theis Lange Anders Perner 《Acta anaesthesiologica Scandinavica》2020,64(9):1365-1375
Introduction
Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID-19 exists.Methods
The COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID-19 receiving ≥10 L/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200 mg daily vs placebo (0.9% saline) for 7 days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all-cause mortality at day 28, day 90, and 1 year; and health-related quality of life at 1 year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28 days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.Discussion
The COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID-19 and severe hypoxia.7.
8.
9.
Heung Bae Kim James J Pomposelli Craig W Lillehei Roger L Jenkins Maureen M Jonas Laura E Krawczuk Steven J Fishman 《Liver transplantation》2005,11(11):1389-1394
Extrahepatic portal vein thrombosis (EHPVT) may occur in children or adults and usually comes to clinical attention due to complications of portal hypertension such as variceal hemorrhage. A variety of standard surgical techniques exist to manage these patients, but when these fail surgical options are limited. We describe two novel portosystemic shunts that utilize the gonadal vein as an autologous conduit. Four patients were evaluated for EHPVT with variceal bleeding. None of the patients were candidates for a standard splenorenal shunt due to prior surgical procedures. The first patient underwent a left mesogonadal shunt and the remaining 3 patients underwent a right mesogonadal shunt. Postoperative ultrasound or computed tomography (CT) scan confirmed early patency of the shunt in each patient. There have been no further episodes of variceal hemorrhage with follow-up of 3.5 years in the child who underwent the left mesogonadal shunt, and 17, 19, and 20 months in the patients who underwent the right mesogonadal shunt. Three of the 4 shunts remain patent. One shunt thrombosis occurred in a patient homozygous for the Factor V Leiden mutation despite anticoagulation with coumadin. This is the first report of the successful use of the gonadal vein as an in situ conduit for constructing a portosystemic shunt. In conclusion, the right and left mesogonadal shunts may be useful as salvage operations for patients with EHPVT who have failed standard surgical shunt procedures. 相似文献
10.
Can carotid endarterectomy be justified? No 总被引:1,自引:0,他引:1
S Jonas 《Archives of neurology》1987,44(6):652-654