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Ensieh Nasli‐Esfahani Maryam Mohammadi‐Khanaposhtani Sepideh Rezaei Yaghoub Sarrafi Zeinab Sharafi Nasser Samadi Mohammad Ali Faramarzi Fatemeh Bandarian Haleh Hamedifar Bagher Larijani Mirhamed Hajimiri Mohammad Mahdavi 《Archiv der Pharmazie》2019,352(8)
A series of new Schiff bases bearing 1,2,3‐triazole 12a ? o was designed, synthesized, and evaluated as α‐glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α‐glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α‐glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α‐glucosidase. 相似文献
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In vitro and in vivo investigation of a novel amniotic‐based chitosan dressing for wound healing
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Maryam Momeni MSc Mohammad Zarehaghighi MD Mirhamed Hajimiri Pharm D Ghasemali Khorasani MD Rassoul Dinarvand Pharm D Abdolhossein Nekookar DVM Niloofar Sodeifi MD Pardis Khosravani MSc Niloofar Shayanasl MSc Marzieh Ebrahimi PhD 《Wound repair and regeneration》2018,26(1):87-101
It is more than a decade that amniotic membrane has been used as a wound dressing because of its anti‐inflammatory, anti‐microbial, anti‐fibrotic, anti‐scarring properties, as well as its pain relieving and epithelialization promoting features. However, amniotic membrane had limited applications because it needs to suture in surgery, is highly fragile, firmly adhere to the wound and may cause bleeding and pain when changing the bandage. This study investigated the possibility of development of a novel amniotic‐based chitosan gel dressing as a potential wound repair substrate with marked efficacy. In this experiment, amniotic gel prepared based on chitosan/PVP gel containing human amniotic membrane extract (AME‐Gel) was investigated in terms of wound‐healing efficacy and scar preventive effects in a rat burn model. The levels of re‐epithelialization and dermal regeneration were examined by histological assessment using H&E and Masson's trichrome staining. Also, we clarified the mechanism of healing and cytokine‐releasing activities of AME as well as its effect on epithelization, angiogenesis, and fibroblast growth and migration. Our results revealed that AME‐Gel induces epidermal and dermal regeneration at a shorter time through formation of granulation tissue, enhancement of fibroblast proliferation, and improvement of blood capillary formation concomitant with developing collagen bundles. Therefore, AME‐Gel could be considered a simple and easy to be used as a biological dressing for any type of superficial burn wounds, without any adverse effects. 相似文献
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