Synthesis of 1-alkyl-3,4-dihydroisoquinoline derivatives and study of their effect on arterial pressure

A series of 1-alkyl-3,4-dihydroisoquinolines and the related 4-alkyl-1,2-dihydro-benzo[f]isoquinolines was synthesized using reactions of dialkylbenzylcarbinols and their naphthyl analogs with alkylcyanides. Experiments showed that 1-alkyl-6,7-dimethoxy-3,4-dihydroisoquinolines typically produce a hypotensive action, while the benzo-annelated structures usually exhibit a hypertensive effects. The most active compound decreases the arterial pressure in cats by 52 Torr and the effect lasts for about 4 hours. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 3, pp. 15–17, March, 2006.     

Synthesis and Study of the Antiaggregant and Hypotensive Properties of N-Benzyl-3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline Derivatives

Pharmaceutical Chemistry Journal -     

Chloromethyl and Aryloxymethyl 3,4-Dihydroisoquinoline Derivatives: Synthesis and Study of Antiaggregant and Antihypoxant Properties

Pharmaceutical Chemistry Journal -     

Antiarrhythmic,Hemostatic, Anthelmintic,and Larvicidal Activity of 3,3-Dialkyl-Substituted Drotaverine Analogs

Pharmaceutical Chemistry Journal - Previously obtained hydrochlorides of 1-[3,4-(R1)2-benzyl]-3,3-(R2)2-6,7-(R3)2-3,4-dihydroisoquinolines (R1 = H, MeO, EtO; R2 = Alk; R3 = MeO, EtO) and their...     

Synthesis and Antiarrhythmic,Hemostatic, Anthelmintic,and Larvicidal Activity of (3,3-Dialkyl-6,7-Diethoxy-3,4-Dihydroisoquinolin-1(2H)-Ylidene)Acetamide Hydrochlorides

Pharmaceutical Chemistry Journal - A series of (3,3-dialkyl-6,7-diethoxy-3,4-dihydroisoquinolin-1(2H)-ylidene)acetamide hydrochlorides were synthesized via Ritter cyclocondensation of...     

Synthesis and Analgesic Activity of 3,3-Dialkyl-Substituted Drotaverine Analogs

Pharmaceutical Chemistry Journal - Ritter reactions of 3,4-(R1)2-benzylcyanides with 1,1-(R2)2-2-[3,4-(R3)2-phenyl]ethanols synthesized...