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Merline Augustine Mohandoss Murugesan Chandran K. Nair Vineetha Raghavan Sangeetha K. Nayanar 《Transfusion and apheresis science》2021,60(3):103073
We present here a case report of a 27 year old female, with myelodysplatic syndrome suspected to have recurrent hyperhemolytic transfusion reactions (HHTR). Patient was transfusion dependent for ten years and was transfused with leukodepleted and irradiated Packed Red Blood Cells (PRBC). She presented with signs and symptoms of acute intravascular hemolysis, deranged coagulation profile with post transfusion Hb lower than baseline. Post transfusion workup was uneventful. She was managed conservatively with fluid support and methylprednisolone initially. After few uneventful transfusions, patient developed second episode of HHTR with compatible unit.Immunophenotype favored an inflammatory response possibly induced by monocytic lineage. As transfusion dependent, the patient required methylprednisolone as premedication and all subsequent transfusions were uneventful. 相似文献
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Podzorski RP Baker J Merline JR Qureshi R Holsinger JE 《Diagnostic microbiology and infectious disease》2000,37(4):289-291
We compared the utility of restriction endonuclease cleavage to type herpes simplex virus DNA polymerase gene amplicons from two well established PCR primer sets. Amplicons typed using Ava II had a 96% correlation to type determined by monoclonal antibody staining, while amplicons typed using Drd I had a 72% correlation to type determined by monoclonal antibody staining. 相似文献
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Hexachlorobenzene uptake by Fathead minnows and macroinvertebrates in recirculating sediment/water systems 总被引:2,自引:0,他引:2
Gerald S. Schuytema Daniel F. Krawczyk William L. Griffis Alan V. Nebeker Merline L. Robideaux 《Archives of environmental contamination and toxicology》1990,19(1):1-9
Fathead minnows (Pimephales promelas), the worm,Lumbriculus variegatus, and the amphipodsHyalella azteca andGammarus lacustris were exposed to hexachlorobenzene (HCB) in water with and without a bed of HCB-spiked sediment. Water HCB concentrations were maintained by recirculation through HCB-packed columns. Recirculating HCB-bound particulates and possibly eroded HCB particulates were an added source of HCB in addition to the sediment bed. Significant bioaccumulation of HCB in animal tissues was observed in water-only and water-sediment exposures. The presence of the HCB-spiked sediment did not result in a significant increase in the uptake of HCB by the organisms, but there was a substantial increase in sediment HCB levels over time. Higher tissue HCB levels in aquaria without sediment suggest that the sediment was a more efficient sink for HCB than the organisms. 相似文献
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Jeffrey A. Moshier Milton G. Mutchnick Julie Dosescu Todd K. Holtz Sami Akkary Kavita Mahakala Joseph R. Merline Paul H. Naylor 《Journal of hepatology》1996,25(6):814-820
Background: Thymosin-α1 is a biological response modifier that has been used clinically, alone and in combination with interferon-α for the treatment of chronic hepatitis B viral infection. Both immunomodulatory and immediate intracelluilar mechanisms have been postulated to explain the effect of these two agents on HBV-infected hepatocytes.Methods: In this study, hepatitis B transfected HepG2 hepatoblastoma cells (HepG2-Nu2), derived from 2.2.15 cells, were used as an in vitro model to determine the efficacy of thymosin-α1 and interferon-α, individually and combined, a proliferation inhibitors of HBV-infected cells. For comparison, parental HepG2 cells and an SV40-transfected HepG2 cell line (HepG2P9T2) were also evaluated.Results: In a clonogenic soft agar assay, thymosin-α1 inhibited the anchorage-independent growth of the HepG2-Nu2 cells by 40% compared with untreated controls, but did not inhibit parental HepG2 or HepG2P9T2 clonal growth. The response was dose dependent over concentrations spanning three log units. In comparison, 10 000 units/ml of interferon-α inhibited parental HepG2, HepG2-N4Z and HepG2P9T2 by 33%, 41% and 87%, respectively. The combination of thymosin-α1 and interferon-α consistently inhibited HepG2-Nu2 clonal growth more effectively than either treatment alone, reaching maximum inhibition levels of 51%.Conclusions: Thymosin-α1 specifically inhibits the tumorigenic growth of HBV-transfected HepG2 cells in contrast to the general inhibition displayed by interferon-α. This panel of cell lines may be an important resource for dissecting the mechanism by which thymosin, alone or in combination with other drugs, influences HBV-infected hepatocytes and/or HBV-associated carcinoma. 相似文献
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Janevic MR Ajrouch KJ Merline A Akiyama H Antonucci TC 《Journal of health psychology》2000,5(4):413-429
Cross-national comparison of the social relations-physical health association in the elderly can broaden our understanding of the implications of social relationships in this age group. Using representative cross-sectional samples of adults aged 60-93 years from metropolitan areas in the United States and Japan (n = 1005), we used analysis of variance to examine between-country differences in the association of illness with measures of network structure, social support, and negative relations. One significant between-country difference in this association was found: in Japan only, ill women reported more available financial help from their child than did non-ill women (p < .05). Ill women in both countries reported less sick care available from their spouse than did ill men (p < .05) and more negative relations with their child than did non-ill women (p < .05). These results suggest the primacy of gender, rather than cultural context, in shaping the association between social relations and health. 相似文献
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Edwige?V.?Ymele A.?Bertrand?Dongmo Théophile?DimoEmail author 《Inflammopharmacology》2013,21(1):21-30
Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-inflammatory effect of this extract was also investigated on carrageenan, histamine or serotonin induced by paw oedema. Aqueous extract of stem bark of A. gabonensis administrated p.o. showed significant activity against paw oedema induced by carrageenan, with a maximum percentage of inhibition reaching the 74.01% at the preventive test at a dose of 200 mg/kg. A. gabonensis exhibited a significant reduction of paw oedema induced by both histamine and serotonin with a maximal inhibition of 56.94% (200 mg/kg) and 40.83% (100 mg/kg), respectively. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. Administered orally at the doses of 100–400 mg/kg, exhibited protective effect of at least 69.78% on the pain induced by acetic acid and also reduced first (67.18% at 200 mg/kg) and second (83.87% at 400 mg/kg) phase of pain-induced par formalin. It also produced a significant increase of the threshold of sensitivity to pressure and hot plate-induced pain in the rats. These results suggest a peripheral and central analgesic activities as well as an anti-inflammatory effect of the stem bark of A. gabonensis. 相似文献
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Zucker RA Wong MM Clark DB Leonard KE Schulenberg JE Cornelius JR Fitzgerald HE Homish GG Merline A Nigg JT O'Malley PM Puttler LI 《Alcoholism, clinical and experimental research》2006,30(2):243-252
This paper summarizes the proceedings of a symposium presented at the 2005 Research Society on Alcoholism meeting in Santa Barbara, California, that spans the interval from toddlerhood to early middle adulthood and addresses questions about how far ahead developmentally we can anticipate alcohol problems and related substance use disorder and how such work informs our understanding of the causes and course of alcohol problems and alcohol use disorder. The context of these questions both historically and developmentally is set by Robert Zucker in an introductory section. Next, Maria Wong and colleagues describe the developmental trajectories of behavioral and affective control from preschool to early adolescence in a high risk for alcoholism longitudinal study and demonstrate their ability to predict alcohol and drug outcomes in adolescence. Duncan Clark and Jack Cornelius follow with a report on the predictive utility of parental disruptive behavior disorders in predicting onset of alcohol problems in their adolescent offspring in late adolescence. Next, Kenneth Leonard and Gregory Homish report on adult development study findings relating baseline individual, spouse, and peer network drinking indicators at marriage onset that distinguish different patterns of stability and change in alcohol problems over the first 2 years of marriage. In the final paper, John Schulenberg and colleagues, utilizing national panel data from the Monitoring the Future Study, which cover the 18- to 35-year age span, show how trajectories of alcohol use in early adulthood predict differential alcohol abuse and dependence outcomes at age 35. Finally, Robert Zucker examines the degree to which the core symposium questions are answered and comments on next step research and clinical practice changes that are called for by these findings. 相似文献
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Emmanuel Jean Teinkela Mbosso Silvère Ngouela Jules Clément Assob Nguedia Véronique Penlap Beng Michel Rohmer Etienne Tsamo 《Journal of ethnopharmacology》2010