全文获取类型
收费全文 | 1411篇 |
免费 | 122篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 71篇 |
妇产科学 | 28篇 |
基础医学 | 146篇 |
口腔科学 | 27篇 |
临床医学 | 145篇 |
内科学 | 429篇 |
皮肤病学 | 17篇 |
神经病学 | 84篇 |
特种医学 | 168篇 |
外科学 | 122篇 |
综合类 | 40篇 |
一般理论 | 1篇 |
预防医学 | 131篇 |
眼科学 | 9篇 |
药学 | 83篇 |
1篇 | |
中国医学 | 6篇 |
肿瘤学 | 34篇 |
出版年
2021年 | 16篇 |
2019年 | 15篇 |
2018年 | 22篇 |
2017年 | 16篇 |
2016年 | 16篇 |
2015年 | 19篇 |
2014年 | 28篇 |
2013年 | 45篇 |
2012年 | 46篇 |
2011年 | 47篇 |
2010年 | 50篇 |
2009年 | 44篇 |
2008年 | 42篇 |
2007年 | 47篇 |
2006年 | 52篇 |
2005年 | 34篇 |
2004年 | 27篇 |
2003年 | 34篇 |
2002年 | 27篇 |
2001年 | 33篇 |
2000年 | 34篇 |
1999年 | 25篇 |
1998年 | 31篇 |
1997年 | 35篇 |
1996年 | 57篇 |
1995年 | 46篇 |
1994年 | 49篇 |
1993年 | 33篇 |
1992年 | 20篇 |
1991年 | 40篇 |
1990年 | 26篇 |
1989年 | 35篇 |
1988年 | 39篇 |
1987年 | 39篇 |
1986年 | 36篇 |
1985年 | 41篇 |
1984年 | 32篇 |
1983年 | 23篇 |
1982年 | 19篇 |
1981年 | 15篇 |
1980年 | 12篇 |
1979年 | 15篇 |
1978年 | 13篇 |
1977年 | 14篇 |
1976年 | 13篇 |
1974年 | 12篇 |
1972年 | 13篇 |
1971年 | 11篇 |
1968年 | 12篇 |
1966年 | 13篇 |
排序方式: 共有1547条查询结果,搜索用时 0 毫秒
1.
2.
G K Hulse V Stalenberg D McCallum W Smit G O'neil N Morris R J Tait 《Journal of controlled release》2005,108(1):43-55
In order to assess the histological tissue changes over time around the site of implant, tissue biopsies were taken at 1 to 38 months post-implant from 54 (34 male) consenting human subjects who had received the Australian subcutaneous naltrexone-poly(DL-lactide) implant for heroin dependence. The implant consists of multiple tablets containing compressed naltrexone-poly[trans-3,6-dimethyl-1,4-dioxane-2,5-dione] (DL-lactide) loaded microspheres. Assessment of tissue samples by pathologists showed an early phase (up to 12 months post-implant) of inflammation, foreign body reaction, and fibrosis. This subsided gradually over the next 12 months until tissue returned to normal by 25+ months. Sufficient evidence was not available to conclude that the poly(DL-lactide) implant matrix was totally biodegradable within the study period. While implant material was not identified in most of the latter biopsies, its presence was noted in one biopsy at 26 months post-implant. Nevertheless the study results did demonstrate the implant's biocompatibility by the lack of inflammation, foreign body reaction, and fibrosis detected by 25+ months. It seems highly probable that surgical technique rather than the implant itself was associated with the additional finding of fat necrosis. Moderate fat necrosis was observed as a common feature of biopsies carried out during the first 6 months following implant. It subsided to mild levels over the next 18 months, and was notably absent by 25+ months. The results of the study indicated that the Australian naltrexone-poly(DL-lactide) implant is well tolerated and may have a role for use in the management of medical conditions such as heroin dependence. 相似文献
3.
Ravinder K. Mittal MD Barry N. Siskind MD Michio Hongo MD M. Wayne Flye MD Richard W. McCallum MD 《Digestive diseases and sciences》1986,31(4):379-384
Three patients with dysphagia caused by compression of the distal esophagus by a tortuous nonaneurysmal atherosclerotic aorta are described. All three patients were elderly women; systemic hypertension and cardiomegaly were present in two patients. Barium studies of the esophagus showed displacement and compression of the distal esophagus by the thoracic aorta. Debilitating dysphagia was treated surgically in one patient. The other two patients had milder symptoms and were managed conservatively. Esophageal manometry in these three patients showed superimposed pulsations and elevated intraluminal pressure just proximal to the lower esophageal sphincter. To evaluate the significance of these manometric findings and their correlation with clinical symptoms, we reviewed manometric tracings in 47 normal subjects. Ten of these subjects had an elevation of baseline intraluminal esophageal pressure as a result of superimposed vascular pulsations. We conclude that (1) compression of the distal esophagus by a tortuous atherosclerotic aorta in the appropriate setting can lead to clinically significant dysphagia and (2) a manometric finding of vascular compression of the esophagus does not necessarily correlate symptomatic dysphagia. 相似文献
4.
Quality of object relations versus interpersonal functioning as predictors of therapeutic alliance and psychotherapy outcome 总被引:1,自引:0,他引:1
W E Piper H F Azim A S Joyce M McCallum G W Nixon P S Segal 《The Journal of nervous and mental disease》1991,179(7):432-438
The purpose of the study was to compare an interview measure of quality of object relations to questionnaire and interview measures of recent interpersonal functioning with respect to the prediction of therapeutic alliance and psychotherapy outcome. The sample consisted of 64 patients who had received approximately 20 sessions of short-term individual psychotherapy within a controlled, clinical-trial investigation. Ratings of therapeutic alliance were provided independently by the patient and the therapist after each session. Outcome measures, which were provided by three sources (patient, therapist, and independent assessor), covered the areas of interpersonal functioning, psychiatric symptomatology, self-esteem, and life satisfaction. Quality of object relations, which characterizes the patient's lifelong pattern of relationships, was the best predictor. It was significantly related to patient-rated and therapist-rated therapeutic alliance and to patient improvement of both general symptomatology and specific target problems. The study also replicated previous studies that have reported significant relationships between therapeutic alliance and therapy outcome. The advantages of pretherapy predictors of therapy outcome, such as quality of object relations, are discussed. 相似文献
5.
Ketai LH; Williamson MR; Telepak RJ; Levy H; Koster FT; Nolte KB; Allen SE 《Radiology》1994,191(3):665
6.
Gastric emptying disorders. Tests and treatments 总被引:2,自引:0,他引:2
R W McCallum 《Postgraduate medicine》1987,81(3):67-76
Tests to measure the volume of gastric contents are necessary to determine the nature of a gastric emptying disorder. The conditions that can affect gastric emptying are as varied as peptic ulcer disease, achlorhydria, viral and bacterial infections of the stomach, diabetes, scleroderma, anorexia nervosa, and CNS lesions; some patients experience gastric emptying problems after surgery for peptic ulcer disease. The future of electrical pacing of the stomach and perhaps the gastrointestinal tract in general is very exciting, as is the future use of antiarrhythmic drugs. 相似文献
7.
A L McCallum 《Canadian journal of surgery》1990,33(6):457-460
Trauma may be accompanied by hypothermia in all climates. Because of the associated increased death rate due to hypothermia (core body temperature less than 35 degrees C), traumatized patients must be protected from it. The body maintains heat balance by hypothalamic regulation of endogenous heat generation and heat loss. Decreased core temperature causes generalized physiologic deceleration and homeostatic disturbances in all organ systems. To prevent hypothermia in polytraumatized patients a number of methods may be used: warming crystalloid, increasing ambient temperature, the use of warming devices, irrigation of body cavities with warmed fluids, heating of inspired gases and, in severe cases when there is circulatory instability, the use of extracorporeal membrane oxygenation. 相似文献
8.
Irfan Soykan Irene Sarosiek Jeannie Shifflett George F. Wooten Dr. Richard W. McCallum 《Movement disorders》1997,12(6):952-957
This study investigated whether domperidone could improve gastrointestinal symptoms in patients with Parkinson's disease who were receiving levodopa therapy. A total of 11 patients were studied. Following a baseline gastric emptying test, patients were treated with a starting dose of domperidone 20 mg p.o. q.i.d. A follow-up gastric emptying test was repeated at least 4 months after starting domperidone therapy. At the beginning and at each 3-month follow-up visit, symptoms of nausea, vomiting, anorexia, abdominal bloating, heartburn, regurgitation, dysphagia, and constipation were evaluated and scored on a scale of 0–3. The overall mean follow-up period was 3 years. Compared with their baseline evaluation, patients experienced a significant improvement in all symptoms (p < 0.05) except dysphagia and constipation. Gastric emptying of an isotope-labeled solid meal was significantly faster, with a baseline result of 60.2 ± 6.4% retention of isotope 2 h after the meal compared with 37.0 ± 2.2% retention during domperidone therapy (p < 0.05). Patients' global assessment of Parkinson's disease remained stable or improved. Serum prolactin was elevated in all patients after domperidone therapy (p < 0.05). Domperidone therapy significantly reduces upper gastrointestinal symptoms and accelerates gastric emptying of a solid meal, but does not interfere with response to antiparkinsonism treatment. 相似文献
9.
Metronidazole susceptibility testing for Helicobacter pylori: comparison of disk, broth, and agar dilution methods and their clinical relevance. 总被引:6,自引:2,他引:4
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A J DeCross B J Marshall R W McCallum S R Hoffman L J Barrett R L Guerrant 《Journal of clinical microbiology》1993,31(8):1971-1974
Since the methods for metronidazole susceptibility testing of Helicobacter pylori have not been standardized or validated, we compared three methods that are used to test the metronidazole susceptibilities of 25 isolates of H. pylori. Specifically, we examined the methods of Steer's replicator agar dilution, tube broth microdilution, and modified Kirby-Bauer disk diffusion. The metronidazole disk zone sizes obtained by the disk diffusion method correlated well (r = 0.74) with the MICs obtained by the agar dilution method. Afterward, the disk diffusion method was used to characterize the metronidazole susceptibilities of 44 isolates of H. pylori. Dual therapy (bismuth and metronidazole) proved to be highly effective against metronidazole-susceptible strains (81.6% eradication rate) but fared poorly against resistant strains (16.7% eradication rate; P < 0.01). Using agar dilution testing, we validated the modified Kirby-Bauer disk diffusion method for metronidazole susceptibility testing of H. pylori and conclude that it is practical, accurate, and clinically applicable. 相似文献
10.
Braffman BH; Coleman BG; Ramchandani P; Arger PH; Nodine CF; Dinsmore BJ; Louie A; Betsch SE 《Radiology》1994,190(3):797