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排序方式: 共有286条查询结果,搜索用时 15 毫秒
1.
2.
Y Inoue T Momose K Machida N Honda T Mamiya T Takahashi T Kamano M Muramatsu A Kashimada 《Radiation Medicine》1992,10(2):45-47
We developed a new method for monitoring the cerebrovascular response to acetazolamide using technetium-99m diethylenetriaminepentaacetic acid human serum albumin (99mTc-DTPA-HSA). We infused 740 M Bq (20 mCi) of 99mTc-DTPA-HSA intravenously and carried out dynamic scanning of the anterior view of the head for 50 minutes. Ten minutes after the start of scanning, 1,000 mg of acetazolamide was injected intravenously. In three normal volunteers, the radioactivity in brain increased for an average of 8 minutes after the injection of acetazolamide and then remained relatively stable. The average of dilatation index [(peak count/the count just before acetazolamide injection-1)x 100] was 16.1. Our method enabled us to observe vasodilation caused by acetazolamide straight, and may be of value in assessing cerebral perfusion reserve easily and quantitatively. 相似文献
3.
4.
Y Endo S Mamiya K Iwamoto H Niitsu T Itoh A Miura 《Rinsho byori. The Japanese journal of clinical pathology》1990,38(2):188-192
Among 300 patients receiving blood and/or blood products because of blood disorders, 3 (1%) were positive for HIV by ELISA. However, 3 patients were thought to be false positive because they had received bolus injection of gamma-globulin and their serum became negative after 6 months. Moreover, no viral inclusion or HIV-antigen was detected. In 30 patients with hemophilia and related disorders, 21 (70%) were positive by ELISA, Immunofluorescence, Passive-agglutination and Western Blot method. Immunodeficiency, as reflected by decreases of CD 4/8 ratio and NK activity, was successfully treated with high-dose of Stronger Neo-Minophagen C. 相似文献
5.
Takaaki Hayashi Katsuhiro Hosono Akiko Kubo Kentaro Kurata Satoshi Katagiri Kei Mizobuchi Minehiro Kurai Norihito Mamiya Mineo Kondo Toshiaki Tachibana Hirotomo Saitsu Tsutomu Ogata Tadashi Nakano Yoshihiro Hotta 《American journal of medical genetics. Part A》2020,182(6):1500-1505
Mucolipidosis type IV (MLIV) is an autosomal recessively inherited lysosomal storage disorder characterized by progressive psychomotor delay and retinal degeneration that is associated with biallelic variants in the MCOLN1 gene. The gene, which is expressed in late endosomes and lysosomes of various tissue cells, encodes the transient receptor potential channel mucolipin 1 consisting of six transmembrane domains. Here, we described 14‐year follow‐up observation of a 4‐year‐old Japanese male MLIV patient with a novel homozygous in‐frame deletion variant p.(F313del), which was identified by whole‐exome sequencing analysis. Neurological examination revealed progressive psychomotor delay, and atrophy of the corpus callosum and cerebellum was observed on brain magnetic resonance images. Ophthalmologically, corneal clouding has remained unchanged during the follow‐up period, whereas optic nerve pallor and retinal degenerative changes exhibited progressive disease courses. Light‐adapted electroretinography was non‐recordable. Transmission electron microscopy of granulocytes revealed characteristic concentric multiple lamellar structures and an electron‐dense inclusion in lysosomes. The in‐frame deletion variant was located within the second transmembrane domain, which is of putative functional importance for channel properties. 相似文献
6.
7.
Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice 总被引:12,自引:9,他引:12
Fukutake M; Nakatsugi S; Isoi T; Takahashi M; Ohta T; Mamiya S; Taniguchi Y; Sato H; Fukuda K; Sugimura T; Wakabayashi K 《Carcinogenesis》1998,19(11):1939-1942
The effects of nimesulide, a selective inhibitor of cyclooxygenase-2
(COX-2) on azoxymethane (AOM)-induced colon carcinogenesis were
investigated in mice. AOM at a dose of 10 mg/kg body wt was administered to
male ICR mice once a week for 6 weeks. The animals were fed on AIN-76A
powder diet containing nimesulide at doses of 200 or 400 p.p.m., starting
the day before the first carcinogen treatment until the end of the
experiment, at week 30. Administration of nimesulide reduced the incidence
of colon carcinomas to 32 and 25% for the AOM + 200 and 400 p.p.m.
nimesulide groups, respectively, compared with the AOM + basal diet group
(50%). Multiplicities of colon carcinomas in the 200 and 400 p.p.m.
nimesulide-treated groups were 0.70 +/- 0.28 and 0.35 +/- 0.11,
respectively, being significantly smaller than the AOM alone value (1.79
+/- 0.47). The sizes of the colon carcinomas in the nimesulide-treated
groups were also decreased. No significant influence on liver and lung
tumor development was apparent. Thus, nimesulide exerted a suppressive
effect on AOM-induced colon carcinogenesis in mice.
相似文献
8.
9.
Katsuhiko Iwakiri Hidenori Kanazawa Satoshi Matsuzaka Norihiko Tada Hitoshi Saitoh Hitoshi Yoshimoto Yoshiya Nakagawa Yuuji Osada Toshiaki Sugiura Makoto Kotoyori Yasutaka Mamiya Hisagi Yamada Yoshiyuki Narahara Akihiko Kawakami Masafumi Kobayashi 《Journal of gastroenterology》1998,33(3):305-309
The effects of transjugular intrahepatic portosystemic shunt (TIPS) placement on esophageal motor function and gastroesophageal
reflux were investigated in patients with esophageal varices. In six men with esophageal varices, esophageal manometry and
upper gastrointestinal endoscopy were performed before and 15–20 days after TIPS placement. Intraesophageal pH monitoring
was performed in the four patients with severe esophageal varices (defined as the largest sized varices) following TIPS placement.
Findings were compared with those in six healthy men (controls) who underwent esophageal manometry and intraesophageal pH
monitoring. The esophageal varices resolved or were reduced after TIPS placement. Resting lower esophageal sphincter (LES)
pressures were similar in the study group before and after TIPS placement and in the control subjects. The incidence and progression
of esophageal contractions were similar in the study group before and after TIPS placement and in the control subjects. At
3 cm above the LES, the amplitude of esophageal contraction after TIPS placement was significantly higher than that before
TIPS placement. At 3 and 8 cm above the LES, the amplitude of esophageal contraction in the control subjects was significantly
higher than that in the study group before and after TIPS placement. Esophageal acid exposure time after TIPS placement was
similar to that in the controls. TIPS placement is a useful treatment that improves esophageal motor function without the
occurrence of pathologic gastroesophageal reflux.
(Received May 28, 1997; accepted Sept. 26, 1997) 相似文献
10.
Atsuko Soeda Takashi Mamiya Yoshinori Hiroshima Hiroaki Sugiyama Sayoko Shidara Yuichi Dai Akira Nakahara Kazuto Ikezawa 《Clinical journal of gastroenterology》2014,7(5):402-409
Collagenous gastritis (CG) is a rare disorder characterized by the thick collagenous subepithelial bands associated with mucosal inflammation. There have been approximately fifty reports in the literature since it was first described in 1989. According to previous reports, CG is heterogeneous and classified into two groups—(1) cases limited to the gastric mucosa in children or young adults, and (2) CG associated with collagenous colitis in elderly adults presenting with chronic watery diarrhea. In Japan, only nine previous cases were reported, and all of them were young adults. We report a case of CG with collagenous duodenitis in a 22-year-old female. She had repeated upper gastrointestinal bleeding from a Dieulafoy lesion of the fornix, but had no symptoms of malabsorption or diarrhea. Endoscopic findings revealed striking nodularity with a smooth islet-shaped normal area in the antrum and the body. The pathological findings of nodular mucosa showed the deposition of collagen bands just under the mucoepithelial lesion. In addition, she had collagenous duodenitis in part of the bulbs, and a colonoscopy showed no abnormalities. We provide a literature review of CG and collagenous gastroduodenitis without colonic involvement. 相似文献