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排序方式: 共有227条查询结果,搜索用时 312 毫秒
1.
Philippe Brun Heykel Kchouk Brigitte Mouchet Véronique Baudouin Alain Raynaud Chantal Loirat Annabelle Azancot-Benisty 《Pediatric nephrology (Berlin, Germany)》1997,11(1):27-30
To evaluate the reliability of Doppler ultrasonography (US) in identifying children with renal artery stenosis (RAS) among
those with hypertension, we compared Doppler US results in 22 hypertensive children (mean age 8.9±4.3 years), with (13 cases)
and without RAS at angiography, and in 33 normotensive children (mean age 8.8±4.7 years). We observed 2 false-negatives and
2 false-positives with Doppler US. Of the 2 false-negative diagnoses, 1 had RAS on an accessory renal artery located behind
a normal upper polar artery and the other was observed in a patient with bilateral multiple stenosis of the very distal segments
of renal arteries. The 2 false-positive diagnoses were due to sinuous left renal artery and to technical reasons, respectively.
In another patient, Doppler US showed a tight RAS, while arteriography was normal. RAS was subsequently confirmed by a second
arteriography. Peak systolic velocity values of Doppler US were significantly higher in patients with proven angiographic
RAS (3.44±0.66 m/s) than in hypertensive patients with normal renal arteries at angiography (0.99±0.35 m/s, P <0.0001) and normotensive healthy children (1.04±0.23 m/s, P <0.0001). With the use of multiple views, and the experience acquired with practice, false-negatives or false-positives due
to the geometry of the renal artery can be avoided. Nevertheless, very distal stenosis can be missed by Doppler US.
Received October 30, 1995; received in revised form April 16, 1996; accepted May 14, 1996 相似文献
2.
A Bisson P Bonnette A Perruchoud M Leroy A Colchen L Raffin P Loirat 《European journal of cardio-thoracic surgery》1992,6(10):568-570
An isolated left lower lobe was used as a left graft, during a bilateral single lung transplantation procedure, in a patient with infected fibrosis. This technique is suitable for patients with small lung volume (especially cystic fibrosis) or asymmetric retraction. 相似文献
3.
B Bader-Meunier E Haddad P Niaudet C Loirat T Leblanc Z Amoura C Bodemer P Cochat G Deschênes I Koné-Paut M Lévy A M Prieur P Quartier B Ranchin R Salomon J C Piette 《Archives de pédiatrie》2004,11(8):941-944
Childhood-onset systemic lupus erythematosus (SLE) is often severe and has a serious long-term morbidity. Pediatric guidelines about its management do not exist. The French study group of childhood-onset SLE proposes recommendations about the investigation which are needed at diagnosis and during follow-up of SLE, in order to adjust the treatment according to the severity of the disease and to avoid unnecessary investigations. 相似文献
4.
Patricia Mariani-Kurkdjian Hélène Cavé Jacques Elion Chantal Loirat and Edouard Bingen 《Clinical microbiology and infection》1997,3(1):117-119
Objective: To reassess the occurrence of verocytotoxin-producing Escherichia coli (VTEC) in French hemolytic uremic syndrome (HUS) patients.
Method: From March 1991 to January 1995, direct detection of verotoxin genes (VT) by the polymerase chain reaction (PCR) was performed on stool samples from 169 patients suffering from HUS.
Results: Fifty-one were PCR positive (30.1%); one was positive for the VT1 gene and the others for the VT2 gene. VTEC was isolated from only 32 of the 51 PCR-positive samples. E. coli O157:H7 was isolated from five patients. E. coli O111 was isolated from seven patients during an outbreak of HUS. Among the other VT2 E. coli strains, only four were serotypable. Of the 51 PCR-positive stools, 19 were culture negative for VTEC.
Conclusions: This study provides evidence that in France E. coli O157 and other VTEC serotypes are involved in HUS. 相似文献
Method: From March 1991 to January 1995, direct detection of verotoxin genes (VT) by the polymerase chain reaction (PCR) was performed on stool samples from 169 patients suffering from HUS.
Results: Fifty-one were PCR positive (30.1%); one was positive for the VT1 gene and the others for the VT2 gene. VTEC was isolated from only 32 of the 51 PCR-positive samples. E. coli O157:H7 was isolated from five patients. E. coli O111 was isolated from seven patients during an outbreak of HUS. Among the other VT2 E. coli strains, only four were serotypable. Of the 51 PCR-positive stools, 19 were culture negative for VTEC.
Conclusions: This study provides evidence that in France E. coli O157 and other VTEC serotypes are involved in HUS. 相似文献
5.
Simon D Rosilio M Maisin A Remesy M Baudouin V Loirat C Czernichow P 《Pediatric nephrology (Berlin, Germany)》1999,13(9):723-729
Sixteen prepubertal patients with chronic renal failure (CRF) were given daily recombinant human growth hormone (rhGH) treatment
(1.2 IU/kg per week) for 2.6±1.6 years until kidney transplant. Therapy was then discontinued and the patients followed for
a further 3.5±1.4 years. During treatment, mean height increased from –3.0±0.9 standard deviation score (SDS) to –1.9±1.4
SDS (P<0.001) at the time of transplantation, corresponding to a mean height gain of +1.2±0.9 SDS. After discontinuation of rhGH
therapy, prepubertal children continued a partial catch-up growth with a height gain of +0.5±0.8 SDS for the follow-up period.
Conversely, negative changes of height were observed in pubertal transplanted children: –0.5±0.4 SDS in patients grafted at
early stages of puberty (P2–P3) and –0.15±0.9 SDS in patients grafted at late stages of puberty (P4–P5). These data confirmed
the benefit of rhGH therapy in CRF patients. Nevertheless, only early initiation of rhGH treatment led some of these patients
to their target height at transplantation, thus preserving their potential growth. Reinitiation of rhGH therapy after transplantation
should be considered in order to complete catch-up growth to target height in prepubertal children.
Received: 23 July 1998 / Revised: 8 December 1998 / Accepted: 13 December 1998 相似文献
6.
Chantal Loirat Fadi Fakhouri Gema Ariceta Nesrin Besbas Martin Bitzan Anna Bjerre Rosanna Coppo Francesco Emma Sally Johnson Diana Karpman Daniel Landau Craig B Langman Anne-Laure Lapeyraque Christoph Licht Carla Nester Carmine Pecoraro Magdalena Riedl Nicole C. A. J. van de Kar Johan Van de Walle Marina Vivarelli Véronique Frémeaux-Bacchi for HUS International 《Pediatric nephrology (Berlin, Germany)》2016,31(1):15-39
7.
Kanamaru Y Arcos-Fajardo M Moura IC Tsuge T Cohen H Essig M Vrtovsnik F Loirat C Peuchmaur M Beaudoin L Launay P Lehuen A Blank U Monteiro RC 《European journal of immunology》2007,37(4):1116-1128
Myeloid cells bear Fc receptors (FcR) that mediate inflammatory signaling through the ITAM-containing FcRgamma adaptor. They express FcRgamma-associated FcalphaRI, which modulate either activating or inhibitory signaling depending on the type of ligand interaction. The role of FcalphaRIgamma in disease progression remains unknown, notably in IgA nephropathy (IgAN), one of major causes of end-stage renal disease, in which large amounts of circulating IgA-immune complexes (IC) may mediate receptor activation. To analyze the involvement of FcalphaRI activation in glomerulonephritis (GN), we generated Tg mice expressing a mutated, signaling-incompetent, human FcalphaRI(R209L) that cannot associate with FcRgamma. Like FcalphaRI(wt)-Tg mice, they developed mesangial IgA deposits but not macrophage infiltration. FcalphaRI activation in FcalphaRI(wt), but not in FcalphaRI(R209L), Tg mice resulted in marked inflammation with severe proteinuria and leukocyte infiltration in spontaneous IgAN or anti-glomerular basement membrane Ab-induced GN models. Receptor triggering of syngenically transferred FcalphaRI(wt) Tg macrophages into non-Tg animals induced their recruitment into injured kidneys during GN development. FcalphaRI(wt) cross-linking on macrophages activated MAP kinases and production of TNF-alpha and MCP-1. Moreover, IgA-IC from IgAN patients activated FcalphaRI and induced TNF-alpha production. Thus, FcalphaRI activation mediates GN progression by initiating a cytokine/chemokine cascade that promotes leukocyte recruitment and kidney damage. 相似文献
8.
9.
Coutant R Leroy B Niaudet P Loirat C Dommergues JP André JL Baculard A Bensman A 《European journal of pediatrics》1999,158(2):154-159
We analysed retrospectively 11 children with renal granulomatous sarcoidosis confirmed by renal histology in order to describe
the course and prognosis of the disease. Symptomatic sarcoidosis was diagnosed at a mean age of 10.1 years. Nine children
had renal involvement at the time of diagnosis. In the course of the disease, nine patients developed renal failure and mild
proteinuria, seven had transient sterile leucocyturia, four showed microscopic haematuria, seven had a urinary concentrating
defect, and enlarged kidneys were seen in three patients. One child had hypercalcaemia and hypercalciuria, none had hypertension.
Light microscopy of the kidney showed interstitial infiltration by mononuclear cells in all children, interstitial fibrosis
in nine patients, epithelioid granulomas in seven, tubular involvement in eight, and mild glomerular involvement in seven
patients. Renal immunofluorescence was negative. Ten children received prednisone for 1–11 years. After a mean follow up of
5.5 years, three patients had entered end-stage renal failure and one had chronic insufficiency after interruption of medical
supervision and prednisone therapy.
Conclusion Renal failure, proteinuria, leucocyturia, haematuria, and concentration defect are the prominent features of renal granulomatous
sarcoidosis in children. Steroid therapy, adjusted according to disease activity, may prevent end-stage renal failure.
Received: 4 December 1997 / Accepted in revised form: 22 June 1998 相似文献
10.