全文获取类型
收费全文 | 5792篇 |
免费 | 188篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 130篇 |
妇产科学 | 28篇 |
基础医学 | 955篇 |
口腔科学 | 113篇 |
临床医学 | 298篇 |
内科学 | 1451篇 |
皮肤病学 | 85篇 |
神经病学 | 557篇 |
特种医学 | 204篇 |
外科学 | 921篇 |
综合类 | 23篇 |
预防医学 | 136篇 |
眼科学 | 43篇 |
药学 | 418篇 |
中国医学 | 14篇 |
肿瘤学 | 604篇 |
出版年
2023年 | 25篇 |
2022年 | 37篇 |
2021年 | 70篇 |
2020年 | 49篇 |
2019年 | 51篇 |
2018年 | 76篇 |
2017年 | 57篇 |
2016年 | 65篇 |
2015年 | 66篇 |
2014年 | 91篇 |
2013年 | 124篇 |
2012年 | 211篇 |
2011年 | 277篇 |
2010年 | 191篇 |
2009年 | 152篇 |
2008年 | 263篇 |
2007年 | 265篇 |
2006年 | 322篇 |
2005年 | 324篇 |
2004年 | 362篇 |
2003年 | 391篇 |
2002年 | 411篇 |
2001年 | 170篇 |
2000年 | 162篇 |
1999年 | 164篇 |
1998年 | 97篇 |
1997年 | 100篇 |
1996年 | 69篇 |
1995年 | 50篇 |
1994年 | 47篇 |
1993年 | 49篇 |
1992年 | 85篇 |
1991年 | 81篇 |
1990年 | 86篇 |
1989年 | 96篇 |
1988年 | 70篇 |
1987年 | 73篇 |
1986年 | 96篇 |
1985年 | 82篇 |
1984年 | 64篇 |
1983年 | 49篇 |
1982年 | 43篇 |
1981年 | 46篇 |
1980年 | 45篇 |
1979年 | 40篇 |
1978年 | 24篇 |
1977年 | 32篇 |
1976年 | 21篇 |
1974年 | 22篇 |
1969年 | 20篇 |
排序方式: 共有6003条查询结果,搜索用时 0 毫秒
1.
2.
The effect of the hepatic energy status on the development of posttraumatic jaundice (PTJ) was studied to clarify the mechanism of PTJ. Fifty-four patients with severe torso injury who were expected to develop PTJ on admission with an average Injury Severity Score of 27 were selected for this study. They were retrospectively divided into three groups according to their maximum bilirubin concentration by day 10: group H, 12 patients with marked elevation of serum bilirubin (>8 g/dl); group L, 23 with mild bilirubinemia (2–8 g/dl); and group N, 19 with no bilirubinemia (<2 g/dl). Group H patients, in whom trauma-related shock was severe and prolonged, developed severe hyperbilirubinemia, and their arterial ketone body ratio (AKBR), which reflects the hepatic mitochondrial redox state and is closely correlated to its energy production, was significantly lower throughout the first week. In contrast, the AKBR increased to an above normal level, indicating enhanced energy production in groups N and L. The serum direct/total bilirubin was also higher in group H. The abnormal hepatic energy metabolism is considered to have reduced the excretion of conjugated bilirubin from the hepatocytes into the bile canaliculi, which is a process that has to proceed against the bilirubin concentration gradient. The subsequent diffusion of the accumulated water-soluble conjugated bilirubin in hepatocytes into the blood is thus considered to be one of the causes of PTJ. 相似文献
3.
Gliomatosis cerebri with good prognosis 总被引:4,自引:0,他引:4
Seiji Kannuki Hideki Hondo Kunio Ii Takanori Hirose Keizo Matsumoto 《Brain tumor pathology》1997,14(1):53-57
A 52-year-old man was admitted to our clinic with severe headache and bilateral papilledema. Magnetic resonance (MR) images
on admission demonstrated diffuse swelling of the cerebral cortex without formation of a tumor mass. Biopsy revealed diffuse
infiltration with neoplastic glial cells. After radiation and chemotherapy, the MR images returned to normal. The morphological
and neurological features of the present case met the criteria for gliomatosis cerebri. However, this patient showed an unusually
good response to radiation and chemotherapy. 相似文献
4.
S Tanaka T Nishihara T Nagashima K Kawai S Nakai M Adachi 《Journal of clinical neuroscience》1997,4(1):57-62
The effects of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (vesnarinone) on the growth of glioma cells were examined in vitro. Vesnarinone at a dose of 100 mug/ml suppressed the growth of four different glioma cell lines, U-251MG, U-373MG, U-87MG and A-172, by approximately 50%, with an elongation of the cytoplasmic process on day 5 of culture. The long-term culture of U-87MG with 10 mug/ml of vesnarinone was continued up to day 34. Although growth suppression was approximately 25% on day 5, it reached over 95% on day 34. An increase in the cyclic adenosine monophosphate content of glioma cells cultured with vesnarinone was observed by enzyme-linked immunosorbent assay (ELISA). The accumulation of glial fibrillary acidic protein was observed to occur with vesnarinone by ELISA. These findings suggest that vesnarinone suppressed the growth and induced differentiation of glioma cells in vitro. 相似文献
5.
Satoru Miyawaki Ryuichi Yamazaki Takehiko Harada Shigehiko Takanashi Tadashi Nagashima Hiroshi Nakaguchi Ryo Okazaki Kazuhito Yamazaki Yasuo Ishida Akira Matsuno 《Journal of clinical neuroscience》2007,14(5):481-484
Skull metastasis of thyroid carcinoma is rare. The majority of skull metastases of thyroid carcinoma are of the follicular subtype, rather than thyroid papillary carcinoma. In this report, a 55-year-old woman with skull metastasis from thyroid papillary carcinoma is presented. The metastatic lesion of the skull was hypervascular and osteolytic, and the bleeding was profuse during resection. There have been only four reports of skull metastasis from thyroid papillary carcinoma. The mean period from the initial diagnosis of thyroid carcinoma until the detection of skull metastasis is 23.3 years, whereas in this patient, it was about 2 years. Therefore, in the clinical course of thyroid papillary carcinoma, skull metastasis should be considered, and the patient should be meticulously followed up. 相似文献
6.
7.
8.
Atsuhiro Yoshida Asami Takeda Katsushi Koyama Yasuhiro Ohtsuka Kunio Morozumi Tadashi Oikawa 《Clinical and experimental nephrology》1997,1(4):292-296
Kimura's disease is a rare disorder that involves regional lymph nodes and the major salivary glands, which become infiltrated
by eosinophils and lymphocytes. Renal lesions associated with Kimura's disease are rare. We describe the case of a 60-year-old
Japanese woman who first noted a nodular mass in a salivary gland. As the nodule grew, nephrotic syndrome and heart failure
developed. A biopsy of the nodule revealed Kimura's disease, and surgical excision was performed. After the operation, the
heart failure and nephrotic syndrome, which were diagnosed as minimal change disease on renal biopsy, improved rapidly without
steroid therapy. Four months later, the nephrotic syndrome recurred without recurrence of Kimura's disease. The patient showed
marked improvement during prednisolone therapy (40 mg/d) and was in complete remission 4 weeks after the initiation of steroid
therapy. This case shows that surgical excision and prednisolone therapy are useful for nephrotic syndrome associated with
Kimura's disease. 相似文献
9.
10.
We have immunohistochemically localized fibronectin, lysozyme and alpha-fetoprotein (AFP) in 21 human hepatocellular carcinoma (HCC) tissues obtained by surgical resection at both light and electron microscopic levels. Three distinct distribution patterns of fibronectin (sinusoidal, periacinar, and pericellular patterns) were observed. The sinusoidal and periacinar patterns were mainly observed in HCC of pseudoglandular or trabecular patterns and of Edmondson's grade I or II, whereas the pericellular pattern was observed in HCC of compact or trabecular patterns and of Edmondson's III grade, suggesting that the pericellular fibronectin was rather associated with undifferentiated HCC. Electron microscopic observation of the pericellular fibronectin showed fibronectin to be present in the dilated intercellular spaces where microvilli were moderately developed. We observed intracytoplasmic staining of fibronectin in 2 of the 21 HCC cases. By immunoelectron microscopy, fibronectin was observed in the endoplasmic reticulum (ER) of some HCC cells. In the 21 HCC cases, lysozyme-positive cancer cells were observed in 10 cases, and AFP in 6 cases. At the ultrastructural level, lysozyme was identified in the ER and the perinuclear spaces of HCC cells, suggesting that lysozyme was synthesized by these cells. Lysozyme-positive cases tended to be more frequently observed in cases with the pericellular pattern of fibronectin rather than those with sinusoidal or periacinar patterns. 相似文献