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1.
Otagiri Masaki Yamamichi Ryuji Marayama Toru Imai Teruko Suenaga Ayaka Imamura Yorishige Kimachi Kazuhiko 《Pharmaceutical research》1989,6(2):156-159
The interactions of acidic and basic drugs with 1-acid glycoprotein (1-AGP) were investigated using circular dichroism (CD) measurements. Extrinsic Cotton effects were generated by the binding of drugs to 1-AGP. The CD data suggested the presence of a single binding site on the 1-AGP molecule. The induced ellipticities of the acidic drug–1-AGP system decreased with increasing pH, while the ellipticities for the basic drugs increased with pH. The ellipticities for all drugs were reduced by the addition of fatty acids. Furthermore, the induced ellipticities decreased in the presence of cesium chloride for basic drugs bound to 1-AGP. The extrinsic Cotton effects therefore appear to result from hydrophobic interaction with 1-AGP for the acidic drugs and from hydrophobic and electrostatic interactions for the basic drugs. 相似文献
2.
Development of hemiacetal esterified levofloxacin to prevent chelation with metal‐containing drugs 下载免费PDF全文
3.
Mikiko Ohta Aiji Noda Eri Ibuki Junko Izumi Mariko Yamamoto Madoka Kimachi 《Nihon Shokakibyo Gakkai zasshi》2002,99(7):779-788
We conducted the statistical analysis of both initial symptoms and clinical symptoms and signs of different etiologies of chronic pancreatitis by using odds ratios which was one of the techniques of evidence-based medicine. The official report published by The Research Group of Intractable Pancreatic Diseases sponsored by the Welfare Ministry of Japan in 1986 was available as the data source of the present study. Nine items of initial symptoms and 25 items of 28 clinical symptoms and signs were compared in 4 different etiologies of the disease which were alcoholic, biliary, idiopatic and nonalcoholic (both biliary and idiopatic). In initial symptoms, 1.5 items were significantly more observed in alcoholic pancreatitis than in nonalcoholic, biliary and idioatic pancreatitis, 4 of which (abdominal pain, back pain, poor appetite and loss of body weight) were common items as might be related closely to the alcohol intake, 2. only one item of jaundice was significantly more observed in biliary pancreatitis than in alcoholic and idiopatic pancreatitis, 3.3 items of poor appetite, diarrhea and abdominal mass were more frequently observed in idiopatic pancreatitis than in biliary pancreatitis. In clinical symptoms and signs, 1. almost all items (21 to 24) were significantly more observed in alcoholic pancreatitis than in the other etiologies of the disease, and seemed to be related directly or indirectly to alcohol intake, 2.3 or 4 items which were related closely to gallstone and acute cholecystitis were significantly more observed in biliary pancreatitis than the other two etiologies of the disease, and 3.4 items consisting of diarrhea, loss of body weight, and pancreatic swelling were more frequently observed in idiopathic pancreatitis than in biliary pancreatitis. 相似文献
4.
Arina Miyoshi So Nagai Masamitsu Takeda Takuma Kondo Hiroshi Nomoto Hiraku Kameda Amiko Hirai Kyuyong Cho Kimihiko Kimachi Chikara Shimizu Tatsuya Atsumi Hideaki Miyoshi 《Journal of diabetes investigation.》2013,4(3):326-329
Aims/Introduction
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder including polycystic ovary morphology (PCOM), ovulatory dysfunction and hyperandrogenism. PCOS is frequently associated with type 2 diabetes mellitus; however, it is unknown whether PCOM and PCOS are prevalent in Japanese patients with type 1 diabetes mellitus. The purpose of our study was to determine the frequency of PCOM and PCOS in women with type 1 diabetes mellitus.Materials and Methods
We evaluated clinical, hormonal and ovarian ultrasound data from 21 type 1 diabetes mellitus patients whose average glycated hemoglobin levels were 7.9 ± 1.5%.Results
Ultrasound identified PCOM in 11 patients (52.4%) and these patients also had higher levels of the androgen dehydroepiandrosterone sulfate (DHEA‐S) than those without PCOM (P < 0.05). Of the patients with PCOM, five presented menstrual irregularities (45.5%) and three met the Japanese criteria for PCOS (27.2%); whereas all patients without PCOM had a normal menstrual cycle (P < 0.05).Conclusions
Japanese premenopausal women with type 1 diabetes mellitus had a high frequency of PCOM as well as PCOS. This is the first research of this area carried out in an Asian population. 相似文献5.
Ikeno D Kimachi K Ibaragi K Kudo Y Goto S Odoh K Itamura S Odagiri T Tashiro M Kino Y 《Vaccine》2011,29(24):4156-4161
The prime-boost response induced by different combinations of four H5N1 vaccines (NIBRG-14 (clade 1), Indo05/2005(H5N1)/PR8-IBCDC-RG2 (clade 2.1), A/Bar-Headed Goose/Qinhai Lake/1A/05 SJ163222 (clade 2.2), and Anhui01/2005(H5N1)-PR8-IBCDC-RG5 (clade 2.3.4)) was evaluated in mice. Clade 1-primed BALB/c mice showed a booster response to all of the other three H5N1 vaccines. Clade 2.2 vaccine was also a good priming vaccine. However, mice primed with clade 2.1 or clade 2.3.4 vaccine did not respond to booster injection with clade 1 vaccine, suggesting that priming might actually inhibit the booster response with some combinations of vaccines belonging to different clades. Analysis of the mechanism involved showed that lymphocytes from primed mice secreted comparable amounts of cytokines with any combination of priming and booster vaccines. Therefore, impairment of B cell immunity specific to certain booster strains may have been involved. 相似文献
6.
Daisuke Ikeno Kazuhiko Kimachi Yasuhiro Kudo Shuro Goto Shigeyuki Itamura Takato Odagiri Masato Tashiro Yoichiro Kino 《Vaccine》2009
We evaluated the priming effect of an H5N1 pandemic vaccine in a mouse model to investigate strategies for influenza pandemic vaccination. For priming, an alum-adjuvanted inactivated whole H5N1 vaccine (NIBRG-14, clade 1) was used. As booster vaccines, several formulations of Indo05/05/2005(H5N1)PR8-IBCDC-RG2 vaccines (clades 2–1) were evaluated, including split, whole, alum-adjuvanted split, and alum-adjuvanted whole vaccines. 相似文献
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8.
Anti pseudorabies virus activity of kumazasa extract 总被引:1,自引:0,他引:1
Iwata K Naito E Yamashita K Kakino K Taharaguchi S Kimachi Y Hara M Takase K 《Biocontrol science》2010,15(4):123-128
Sasa veitchii or "kumazasa" has been used for the preservation of food, or preventing bacterial activity. However, the antiviral activity of kumazasa is poorly understood. In the present study, the antiviral activity of kumazasa extract (KE) was assessed by the plaque reduction assay for the pseudorabies virus (PRV). KE reduced 99% of the plaque formation of PRV at concentrations of 1.2%, showing that KE inhibited PRV adsorption to cells and IE180 expression. The polysaccharide fraction of KE showed a concentration dependent inhibition of PRV plaque formation. We conclude that KE possesses potent anti PRV activity, and the candidate responsible for the antiviral property was the polysaccharide fraction. 相似文献
9.
Minoru Nakao Taiichiro Nagaishi Masakatsu Inoue Hidekazu Kimachi Shigemasa Koga 《Surgery today》1977,7(4):269-278
To elucidate the mechanism of portal hypertension seen as a symptom of so-called Banti's syndrome (idiopathic portal hypertension),
observation was made of rising of the portal pressure experimentally induced in sensitized rabbits.
Intraintestinal injection of the same antigen as used for the sensitization resulted in elevation of the portal pressure.
This phenomenon appears to be attributable to antigen-antibody reaction caused by the injected antigen absorbed from the intestine
and entered thereby into the portal system while maintaining its antigenicity. From the phenomenon also, the site of the antigen-antibody
reaction is estimated to be limited at least to the hepatic level. The portal pressure-rising phenomenon observed following
intraintestinal introduction of antigen may suggest the possibility of entrance of the orally introduced antigen to the portal
system, emphasizes importance of alimentary factors in the genesis of this syndrome. 相似文献
10.