全文获取类型
收费全文 | 696篇 |
免费 | 46篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 13篇 |
妇产科学 | 1篇 |
基础医学 | 70篇 |
口腔科学 | 6篇 |
临床医学 | 45篇 |
内科学 | 86篇 |
皮肤病学 | 87篇 |
神经病学 | 40篇 |
特种医学 | 240篇 |
外科学 | 22篇 |
综合类 | 2篇 |
预防医学 | 45篇 |
眼科学 | 6篇 |
药学 | 63篇 |
中国医学 | 2篇 |
肿瘤学 | 19篇 |
出版年
2020年 | 8篇 |
2019年 | 4篇 |
2018年 | 10篇 |
2017年 | 6篇 |
2016年 | 15篇 |
2015年 | 8篇 |
2014年 | 9篇 |
2013年 | 8篇 |
2012年 | 23篇 |
2011年 | 26篇 |
2010年 | 17篇 |
2009年 | 14篇 |
2008年 | 15篇 |
2007年 | 20篇 |
2006年 | 22篇 |
2005年 | 14篇 |
2004年 | 17篇 |
2003年 | 12篇 |
2002年 | 18篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 14篇 |
1998年 | 21篇 |
1997年 | 21篇 |
1996年 | 18篇 |
1995年 | 14篇 |
1994年 | 22篇 |
1993年 | 18篇 |
1992年 | 10篇 |
1991年 | 6篇 |
1990年 | 10篇 |
1989年 | 28篇 |
1988年 | 26篇 |
1987年 | 27篇 |
1986年 | 17篇 |
1985年 | 25篇 |
1984年 | 28篇 |
1983年 | 22篇 |
1982年 | 13篇 |
1981年 | 19篇 |
1980年 | 15篇 |
1979年 | 13篇 |
1978年 | 17篇 |
1977年 | 7篇 |
1976年 | 9篇 |
1975年 | 7篇 |
1971年 | 8篇 |
1968年 | 5篇 |
1967年 | 3篇 |
1966年 | 2篇 |
排序方式: 共有748条查询结果,搜索用时 15 毫秒
1.
2.
3.
Normal and diseased isolated lungs: high-resolution CT 总被引:8,自引:0,他引:8
4.
Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. 总被引:1,自引:0,他引:1
Collins CE Benson MJ Burnham WR Rampton DS 《Alimentary pharmacology & therapeutics》1996,10(3):315-320
BACKGROUND: Inflammatory bowel disease is associated with increased mucosal release of eicosanoids. Among these, thromboxane A2 has been proposed as a possible inflammatory mediator; its suppression may be a useful therapeutic option. METHODS: Using a tissue incubation technique, we compared release of immunoreactive thromboxane B2 by colonic biopsies from patients with ulcerative colitis, Crohn's disease and controls, and assessed the inhibitory effect of picotamide, a thromboxane synthesis inhibitor-receptor antagonist, which has been widely used in Italy for management of ischaemic heart and cerebrovascular disease. RESULTS: Increased amounts of thromboxane B2 were released from biopsies from patients with active ulcerative colitis (median 238 pg/20 min/mg wet weight (interquartile range 147- 325), n = 12) and active Crohn's disease (252 (174-450), 6) compared with those from patients with quiescent ulcerative colitis (95 (61- 140), 12) or Crohn's disease (105 (57-201), 13), or controls (136 (64- 206), 8). Incubation with picotamide at concentrations between 100 microM and 1 mM reduced thromboxane B2 release (IC50 890 microM). CONCLUSION: Since increased thromboxane A2 production may have pathogenetic importance, thromboxane synthesis inhibitor-receptor antagonists such as picotamide merit therapeutic trial in the management of inflammatory bowel disease. 相似文献
5.
6.
7.
Hydrosalpinges adversely affect markers of endometrial receptivity 总被引:22,自引:10,他引:22
Meyer WR; Castelbaum AJ; Somkuti S; Sagoskin AW; Doyle M; Harris JE; Lessey BA 《Human reproduction (Oxford, England)》1997,12(7):1393-1398
While in-vitro fertilization (IVF) was initially developed in women with
tubal factor infertility, recent clinical studies have suggested that the
presence of hydrosalpinges lowers implantation and pregnancy rates. We
postulated that these hydrosalpinges cause impaired endometrial
receptivity. A total of 103 women with hydrosalpinges were prospectively
evaluated, and compared with 55 infertile and 44 fertile controls. All
women had endometrial biopsies during the window of implantation, analysed
by conventional histological criteria, and also stained for three integrin
markers of endometrial receptivity (alpha1beta1, alpha4beta1 and alpha
vbeta3). Women with hydrosalpinges (cases) expressed significantly less of
the alpha vbeta3 integrin compared with controls. There was no difference
in expression of alpha1beta1 or alpha4beta1 among groups. A significantly
greater number of cases had out of phase histology and missing alpha vbeta3
(type I defects) and absent integrin expression despite normal histological
maturation (type II) defects, compared with controls. Of 20 women with
impaired endometrial receptivity who were also biopsied after hydrosalpinx
surgery, 70% demonstrated increased alpha vbeta3 expression. Seventy-seven
percent of type I and 57% of type II defects were corrected
postoperatively. Using markers of endometrial receptivity, this study
demonstrates that inflammatory hydrosalpinges have an adverse effect on
endometrial receptivity, which in some cases may be overcome by surgical
treatment of the hydrosalpinx.
相似文献
8.
9.
10.
Garaczi E Széll M Jánossy T Koreck A Pivarcsi A Buzás E Pos Z Falus A Dobozy A Kemény L 《International immunology》2004,16(12):1781-1788
Histamine plays an important role in the regulation of various immunological functions. To evaluate the role of histamine in contact hypersensitivity, contact dermatitis was induced with dinitrofluorobenzene (DNFB) in histidine decarboxylase knockout (HDC-/-) histamine-deficient and wild-type mice. The DNFB-induced increase of the ear thickness was significantly higher in HDC-/- mice than in wild-type mice. Using flow cytometry, significantly lower percentages of CD4+ Th and CD8+ Tc cells, and significantly higher percentages of CD45R+ B cells were observed in the regional lymph nodes in HDC-/- mice than in wild-type mice. In the ear specimens of both groups, the majority of the infiltrating cells were neutrophils and macrophages at 24 and 48 h after challenge. Using immunohistochemistry, we observed significantly more CD45+ leukocytes in HDC-/- mice than in wild-type mice. The expression of Th1 (IL-2, IFN-gamma, TNF-alpha) and Th2 (IL-4) mRNAs was examined by quantitative real time RT-PCR in the ear samples. The levels of Th1 cytokine mRNAs both at 24 and 48 h after challenge and IL-4 mRNA at 48 h showed a significantly higher increase in HDC-/- mice than in wild-type mice. These results suggest that histamine plays a negative immunoregulatory role in DNFB-induced contact hypersensitivity. 相似文献