全文获取类型
收费全文 | 459篇 |
免费 | 17篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 8篇 |
妇产科学 | 28篇 |
基础医学 | 49篇 |
口腔科学 | 13篇 |
临床医学 | 26篇 |
内科学 | 78篇 |
皮肤病学 | 11篇 |
神经病学 | 38篇 |
特种医学 | 35篇 |
外科学 | 101篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 12篇 |
眼科学 | 5篇 |
药学 | 13篇 |
肿瘤学 | 22篇 |
出版年
2023年 | 4篇 |
2022年 | 1篇 |
2021年 | 9篇 |
2020年 | 5篇 |
2019年 | 13篇 |
2018年 | 7篇 |
2017年 | 11篇 |
2016年 | 12篇 |
2015年 | 11篇 |
2014年 | 18篇 |
2013年 | 19篇 |
2012年 | 25篇 |
2011年 | 29篇 |
2010年 | 18篇 |
2009年 | 13篇 |
2008年 | 30篇 |
2007年 | 20篇 |
2006年 | 35篇 |
2005年 | 40篇 |
2004年 | 39篇 |
2003年 | 29篇 |
2002年 | 26篇 |
2001年 | 9篇 |
2000年 | 11篇 |
1999年 | 9篇 |
1998年 | 3篇 |
1997年 | 4篇 |
1996年 | 10篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1988年 | 1篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有482条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Mohsen Chiani Kayhan Azadmanesh Mohammad Ali Shokrgozar Mohammad Reza Mehrabi Azim Akbarzadeh Dariush Norouzian 《Chemical biology & drug design》2017,90(5):953-961
Folate receptor (FR)‐mediated drug delivery is a promising approach for active targeting of drugs to the FR‐positive tumor cells. Bleomycin (BLM) is an antitumor antibiotic with poor therapeutic activity as a result of its limited diffusion into tumor cells. The aim of this study was to investigate whether FR‐targeted PEGylated nanoliposomes (FPNL) can effectively deliver BLM to tumor cells and enhance its in vitro and in vivo efficacy. FPNL and PNL (non‐targeted) were prepared by thin film hydration method, and their physiochemical properties, cellular uptake, tissue distribution and tumor inhibitory effects were investigated. In Lewis lung cancer (LLC1) cells, FPNL containing BLM showed 2.38‐fold and 3.26‐fold higher cytotoxicity compared to PNL‐BLM and free BLM, respectively. Moreover, the uptake of FPNL by these cells was increased as compared to the PNL. Furthermore, FPNL showed significantly higher tumor distribution of BLM in the LLC1 cells and more tumor inhibition efficacy compared to free BLM and PNL. Both formulations of nanoliposomes had longer plasma half‐life than that of free BLM. Therefore, FPNL may be suitable carriers for targeted drug delivery to FR‐positive tumor cells. 相似文献
6.
7.
8.
Uzuner Selcuk Durcan Gizem Sahin Sezgin Bahali Kayhan Barut Kenan Kilicoglu Ali Guven Adrovic Amra Bilgic Ayhan Kasapcopur Ozgur 《Clinical rheumatology》2021,40(12):5025-5032
Clinical Rheumatology - Having a child with a chronic illness is a source of stress for the whole family, especially the primary caregiver. The aim of this study was to evaluate the associations... 相似文献
9.
10.
ERCP subsequent to retroperitoneal perforation caused by endoscopic sphincterotomy 总被引:13,自引:0,他引:13
BACKGROUND: Perforation occurs after endoscopic sphincterotomy in 0.4% of cases. With recognition of a perforation, the procedure usually is aborted and further attempts at ERCP are thought to be precluded by the complication. The aim of this study was to determine the timing and the outcome of ERCP after retroperitoneal perforation caused by endoscopic sphincterotomy when the initial ERCP was incomplete. METHODS: A total of 1787 patients underwent endoscopic sphincterotomy during a period of 29 months. A type II duodenal perforation was recognized in 15 patients, whereupon the ERCP, including further intervention, was halted. Eight patients agreed to undergo a second therapeutic ERCP to complete the treatment of the primary disease. OBSERVATIONS: Therapeutic ERCP was repeated in all patients from 11 to 15 days after the perforation. Treatment was successfully completed in all patients without complication. CONCLUSIONS: Therapeutic ERCP may be repeated and has a high success rate in patients who sustain a perforation caused by endoscopic sphincterotomy. 相似文献