Solitary pancreatic metastasis from squamous cell lung carcinoma: A case report and review of literature

BACKGROUNDPancreatic metastases from squamous cell lung carcinoma (SCLC) are unusual. These lesions are often asymptomatic and detected incidentally or during follow-up investigations, occasionally several years after removal of the primary tumor.CASE SUMMARYA 56-year-old male with SCLC developed jaundice 1 mo after the cancer diagnosis. An abdominal computed tomography (CT) scan showed a mass in the pancreatic head with distention of both intra- and extrahepatic biliary ducts. Endoscopic retrograde cholangiopancreatography and sphincterotomy were performed first, culminating with plastic biliary stent placement. Cytological examination of the pancreatic mass sample collected by fine-needle aspiration (FNA) under endoscopic ultrasound (EUS) guidance revealed the presence of malignant cells compatible with well-differentiated squamous cell carcinoma. After liver function normalized, chemotherapy was initiated with carboplatin and paclitaxel; however, 4 d later, the patient presented dysphagia. Cervico-thoraco-abdominal CT showed tracheoesophageal fistula and stent migration. After replacement with a 10 cm/10 mm uncovered metallic biliary stent and treatment of the tracheoesophageal fistula with a fully covered esophageal stent, the patient was able to start oral feeding progressively. He died 9 mo after the initial diagnosis.CONCLUSIONThe diagnosis of pancreatic metastasis from SCLC is challenging for clinicians. EUS-FNA is the primary exam for confirmatory diagnosis.     

Occupational exposure to coal and risk of multiple health outcomes: A case report

Occupational cutaneous squamous‐cell carcinoma has an increased incidence, but rarely suspected. When located in an uncovered skin area, it is closely linked to polycyclic aromatic hydrocarbons exposure. However, single pulmonary anthracosis nodule is rarely described in the literature. The association of both diseases due to the same exposure remains uncommon.     

Comparison of four techniques for the measurement of lung volumes and airway resistances by plethysmography

OBJECTIVE: To search influence of measurement technique of thoracic gas volume(Vgt) and airway resistance(Raw) by plethysmography on results. MATERIALS AND METHODS: 20 healthy subjects, aged 22.75 + 0.40 years were studied. Vgt and Raw were measured by series of gentle panting manoeuvres (GPM) or calm respiration (CR) before and after closure of a shutter valve. So, four methods were compared : method 1 (M1) CR before ahd after, method 2 (M2): CR before and GPM after, method 3 (M3) GPM before and CR after, and method 4 (M4): GPM before and after the closure of the shutter valve. Five tests were maked with each method. RESULTS: There is no significant inter-tests variability with each method. Raw(cm H2O/L/s) measured by M1 and M2 were so elevated if compared to M3 and M4 (M1 : 2.65 + 0.102; M2: 2.47 + 0.171; M3: 1.21 + 0.080; M4: 1.30 + 0.102 ; p < 0.05).There is also a significant variability intermethods in Vgt I): (M1: 3.53 + 0.188; M2 : 3.60 + 0.203; M3 : 3.91 + 0.262; M4: 3.84 + 0.247; p < 0.05). CONCLUSION: The plethysmography measurement method must be considered in the interpretation of Vgt and Raw values.