全文获取类型
收费全文 | 368篇 |
免费 | 4篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 54篇 |
妇产科学 | 11篇 |
基础医学 | 44篇 |
口腔科学 | 13篇 |
临床医学 | 20篇 |
内科学 | 45篇 |
皮肤病学 | 18篇 |
神经病学 | 11篇 |
特种医学 | 33篇 |
外科学 | 24篇 |
综合类 | 8篇 |
预防医学 | 19篇 |
眼科学 | 17篇 |
药学 | 33篇 |
肿瘤学 | 14篇 |
出版年
2013年 | 4篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2006年 | 5篇 |
2002年 | 1篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1998年 | 3篇 |
1997年 | 10篇 |
1996年 | 9篇 |
1995年 | 4篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 7篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 4篇 |
1973年 | 6篇 |
1970年 | 1篇 |
1968年 | 3篇 |
1967年 | 1篇 |
1966年 | 4篇 |
1965年 | 2篇 |
1964年 | 1篇 |
1963年 | 2篇 |
1962年 | 1篇 |
1961年 | 2篇 |
1960年 | 1篇 |
1959年 | 21篇 |
1958年 | 36篇 |
1957年 | 37篇 |
1956年 | 44篇 |
1955年 | 38篇 |
1954年 | 53篇 |
1952年 | 2篇 |
1951年 | 1篇 |
1949年 | 4篇 |
1948年 | 8篇 |
1947年 | 1篇 |
排序方式: 共有372条查询结果,搜索用时 15 毫秒
1.
KOCH ML 《American journal of obstetrics and gynecology》1948,56(6):1142-1145
This investigation comprises a study of 72 patients from the wards and private service of the Women's Clinic of the Johns Hopkins Hospital. Seven patients had had a previous history of gonorrheal infection, 40 had doubtful histories and 25 had negative histories.In 1921 Curtis isolated the gonococcus from Fallopian tubes removed at operation in 38 of 192 cases, but gross and microscopically these tubes presented a picture of acute inflammation. Curtis also isolated Escherichia coli, streptococci, and anaerobic streptococci from cases of salpingitis and perisalpingitis. Cordua and Keck in 1926, reported isolating paratyphoid B bacillus from an ovarian abscess. In 1931 Worral reported having isolated Staphylococci from infected Fallopian tubes. Caussade and Giullemin, 1934, isolated the colon bacillus from the tubes of a 12-year-old girl. Brown, 1935, isolated Salmonella newport from a case of bilateral pyosalpinx. Studdiford, Casper, and Scadron, in 1938, reported isolating gonococci from the tubes of 16 of 24 cases studied. The organisms were isolated by culturing pieces of tissue and exudate, never from pus, and occasionally were degenerate in form but rapidly assumed the usual characteristics upon subculture. Thirteen of the specimens yielding gonococci showed pathologic evidence of subacute inflammation, two were acute exacerbations of chronic salpingitis, and one showed evidence of chronic or healed salpingitis with marked structual changes in the walls of the tube. According to Cornell, until 1934 there were 71 published cases of actinomycosis of the internal female genitals. American literature reported seven cases, English literature six, and the remainder were in other languages. Since then cases have been reported by Gardiner and Welsh, 1935; Côte and Tudhope, 1936; De Faria and Fiablo, 1937; Auster, 1940; and Ahumada and Chevalier, 1943. 相似文献
2.
Effects of N-acetylcysteine on bacterial clearance 总被引:3,自引:0,他引:3
T. KOCH S. HELLER S. HEIßLER I. BREIL H. G. SCHIEFER† K. VAN ACKERN H. NEUHOF 《European journal of clinical investigation》1996,26(10):884-892
Abstract. The aim of this study was to investigate whether the oxygen radical scavenger N -acetylcysteine ( N -AC) impairs bacterial clearance, thus predisposing the host to increased risk of disease. Blood clearance of Escherichia coli and organ colonization were investigated in anaesthetized rabbits after pretreatment with N -AC (250 mg kg-1 body weight, n = 16) and in sham-operated animals ( n = 12). To enable quantification of the clearance process, defined numbers of exogenous E. coli [1.3 times 108 colony-forming units (CFUs)] were injected intravenously. Parameters monitored were kinetics of bacterial elimination from the blood, and polymorphonuclear leucocyte (PMN) oxidative burst activity. Samples of liver, kidney, spleen and lung were collected for bacterial counts. Compared with controls, pretreatment with N -AC resulted in delayed bacterial elimination from blood and higher organ colonization with increased numbers of E. coli in liver, lung and kidney ( P < 0.05). N -AC treatment was associated with a suppressed PMN oxidative burst activity. Impaired bacterial clearance and enhanced organ colonization in N -AC-treated animals correlated with reduced oxidative burst activity, suggesting impaired granulocyte-dependent bacterial killing due to N -AC application. 相似文献
3.
4.
KLEOMENIS BARLOS DIMITRIOS GATOS OLGA HATZI NICOLE KOCH SOFIA KOUTSOGIANNI 《Chemical biology & drug design》1996,47(3):148-153
S-4-methoxytrityl cysteine was synthesized and converted into the corresponding Fmoc-Cys(Mmt)-OH by its reaction with Fmoc-OSu. As compared to the corresponding Fmoc-Cys(Trt)-OH, the S-Mmt-function was found to be considerably more acid labile. Quantitative S-Mmt-removal occurs selectively in the presence of groups of the tert butyl type and S-Trt by treatment with 0.5–1.0% TFA. The new derivative was successfully utilized in the SPPS of Tyr1-somatostatin on 2-chlorotrityl resin. In this synthesis groups of the Trt-type were exclusively used for amino acid side-chain protection. Quantitative cleavage from the resin and complete deprotection was performed by treatment with 3% TFA in DCM–TES (95:5) for 30 min at RT. We observed no reduction of tryptophan under these conditions. © Munksgaard 1996. 相似文献
5.
6.
Autoradiographic studies have shown that radioiodinated TIGAL binds in vitro to a small but varying fraction of lymphoid cells from bursectomized, agammaglobulinemic chickens, whereas no binding of radioiodinated TGAL or a variety of other radioiodinated antigens can be observed. The binding of [125I]TIGAL is inhibited by antigen-antibody complexes. Radioiodinated antigen-antibody complexes are bound to a similar proportion of the lymphoid cells from bursectomized chickens, and this binding is inhibited by preincubation of the cells with unlabeled TIGAL but not with TGAL. These results indicate a cross-reaction at the level of Fc receptors between determinants on TIGAL and on IgG. 相似文献
7.
8.
9.
10.