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排序方式: 共有226条查询结果,搜索用时 31 毫秒
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IKURO KIMURA YOSHIRO TANIZAKI KATSUYOSHI SAITO KIYOSHI TAKAHASHI NOBUO UEDA SHUICHI SATO 《Clinical and experimental allergy》1975,5(1):95-98
A total of 108 samples of sputum obtained from twenty patients with bronchial asthma were examined for appearance of basophils and eosinophils. Both cell types are present in sputum during an asthmatic attack and disappear at the conclusion of the attack. Their presence correlates with the severity of the disease. It has previously been demonstrated that the blood basophils count falls during attacks of bronchial asthma, and the present study suggests that basophils move from the blood stream into bronchial tissue during the acute phase of an asthmatic attack. 相似文献
3.
TANIGUCHI CHISA; YAMAGUCHI KAZUNARI; YOSHIOKA RITSUKO; TAKIFUJI NOBUHIDE; MATSUI KAORU; NISHIMURA HIROMICHI; TOMINO SHINHACHIRO; TAKATSUKI KIYOSHI; TANAKA RYUJI 《Japanese journal of clinical oncology》1984,14(1):123-127
We report a case of chronic myelogenous leukemia (CML) associatedwith pronounced peripheral lymphadenopathy, with the cells havingthe Philadelphia (Phl) chromosome and T-cell features. A 23-year-oldman who was diagnosed as having CML and treated with busulfanwas admitted to our hospital because of increasing hepatosplenomegalyand pronounced lymphadenopathy. An axillary lymph node biopsydisclosed that the malignant cells formed rosettes with neuraminidase-treatedsheep red blood cells (En) (95.0%) and were positive for Leu1 (91.8%). Of the cytochemical reactions, peroxidase was negativeand periodic acid-Shiff, acid -naphthyl acetate esterase andß-glucuronidase were all positive. The karyotype ofthe bone marrow cells was 46 XY Phl positive (22q), andthat of the lymph node cells was 51 XY Phl positive +8, +9,+18, +19, +21, 22q. He was treated with various anti-leukemicagents and irradiation. Despite such treatments, he died ofpneumonia. This is a report of a CML patients with blast crisisand tumor formation characterized by T-cell features. 相似文献
4.
Takuya HASEGAWA Chiyoe MURATA Takashi NINOMIYA Tomoko TAKABAYASHI Tatsuya NODA Shinya HAYASAKA Mieko NAKAMURA Toshiyuki OJIMA 《Industrial health》2013,51(5):490-500
Problem drinking is a serious public health problem in the workplace. However, few
Japanese epidemiological studies have investigated the occupational characteristics of
problem drinking. The purpose of this study is to clarify the occupational risk factors
for problem drinking among a Japanese working population. We used data from a
random-sampling survey about mental health and suicide, conducted among Hamamatsu City
residents aged 15 to 79 yr old during May and June in 2008. The relation between
occupational factors and problem drinking was analyzed with multiple logistic regression
models stratified by gender. CAGE questionnaire was used to assess problem drinking. With
regard to employment types, problem drinkers were more prevalent among self-employed
women. With regard to occupational types, clerical and service professions had more
problem drinkers of either sex, while administrative/managerial and sales professions had
more women with such problem. With regard to company size, male problem drinkers were more
prevalent in smaller companies than in larger ones. These results indicate that the
prevalence of problem drinkers in the workplace depends on where one works. It is
necessary to consider these characteristics to provide effective measures to address
problem drinking in the workplace. 相似文献
5.
Ying HAN Gang CHEN Ying Xin SONG Yuhji MURATA Jugoh ITOH Akihiro MUNAKATA 《Journal of digestive diseases》2003,4(1):9-12
OBJECTIVE: To investigate the in vitro effect of Tripterygium glycosides (TG) on cytokine production by splenocytes in oxazolone (OXZ)‐induced colitis in mice. METHODS: Oxazolone (6 mg in 50% ethanol) was administered to male SJL/J mice intrarectally to induce colitis and the mice were killed 3 days later. Isolated splenocytes were cultured for 24 h in the presence of phorbol myristate acetate and ionomycin. A preparation of Tripterygium glycosides at a concentration of either 0.1 mg/mL or 0.01 mg/mL was added to the culture medium of splenocytes. Production of interferon gamma (IFN‐γ) and interleukin‐4 (IL‐4) in the supernatant were measured by ELISA. RESULTS: Production of IFN‐γ in the normal control group was suppressed by TG at both concentrations (0.01 and 0.1 mg/mL; 1.24 ± 0.13 pg/mL (samples without TG) → 0.97 ± 0.26 pg/mL (0.01 mg/mL TG) → 0.87 ± 0.18 pg/mL (0.1 mg/mL TG); P < 0.02) in a dose dependent manner. In the OXZ‐induced colitis group, the basic level of IFN‐γ was significantly lower than that of the normal control group (1.24 ± 0.13 pg/mL vs 0.65 ± 0.08 pg/mL; P < 0.01); but IL‐4 production was significantly increased in the OXZ‐induced colitis without TG group (7.83 ± 0.69 pg/mL vs 5.65 ± 0.48 pg/mL, P < 0.01). In both groups, TG suppressed IL‐4 production in a dose‐dependent manner (normal control group: 5.65 ± 0.48 pg/mL (samples without TG) → 4.97 ± 0.38 pg/mL (0.01 mg/mL TG) → 3.98 ± 0.32 pg/mL (0.1 mg/mL TG), P < 0.01; OXZ group: 7.83 ± 0.69 pg/mL (samples without TG) → 7.07 ± 0.47 pg/mL (0.01 mg/mL TG) → 6.35 ± 0.48 pg/mL (0.1 mg/mL TG), P < 0.01). CONCLUSION: Oxazalone‐induced IL‐4 overproduction by splenocytes was significantly suppressed by TG in a dose dependent manner and the beneficial effects of TG on ulcerative colitis might be related to the suppression of the Th2 type (e.g. IL‐4) mediated immunological response of splenocytes. 相似文献
6.
HIROSHIGE MURATA M.D. YASUSHI MIYAUCHI M.D. TAKASHI NITTA M.D. KYOICHI MIZUNO M.D. 《Journal of cardiovascular electrophysiology》2010,21(11):1296-1299
Ventricular Tachycardia After Alcohol Septal Ablation. A 76‐year‐old female developed 2 different ventricular tachycardias (VTs) 5 years after alcohol septal ablation (ASA) for symptomatic hypertrophic obstructive cardiomyopathy. VT#1 was a small macroreentry at the anterior border of the low‐voltage zone, suggesting the ASA‐scar and eliminated by endocardial ablation at a site recording fractionated potentials covering the mid‐diastolic and presystolic periods. VT#2 was a focal VT and eliminated by epicardial cryoablation at the basal posterior left ventricle, suggesting the posterior border of the ASA‐scar. Using the electroanatomical mapping, we demonstrated that the mechanism of the VTs was reentry at the edge of the ASA‐scar. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1296‐1299, November 2010) 相似文献
7.
KATSUYA YAMAMOTO MASARU TAKAYANAGI YASUSHI YOSHIHARA YUJI MURATA SEIICHI KATO MASATOSHI OTAKE HIROSHI NAKAGAWA 《Pediatrics international》1996,38(1):46-51
An 8 year old girl with acute disseminated encephalomyelitis (ADEM) is described. Elevated serum antibody titers suggested recent Mycoplasma pneumoniae infection. T2-weighted image of magnetic resonance imaging (MRI) disclosed multiple lesions of high signal intensity in bilateral basal ganglia and thalami as well as in the white matter. Postcontrast T1-weighted image revealed an enhanced lesion in the deep white matter. She showed rapid clinical improvement in response to corticosteroid therapy. The lesions had disappeared completely on MRI performed 10 weeks after the onset. ADEM is believed to be a demyelinating disorder of probable autoimmune etiology. MRI findings in this case may support the hypothesis that the primary pathological event is vascular injury and demyelination occurs only as a secondary phenomenon. 相似文献
8.
KIYOSHI KAWAKAMI MD TOSHIRO TAKEZAKI SHIN-ICHI NAKAZONO TAKUMA KITAHARA NAOAKI IKARIMOTO YUJI TANAKA KOICHIRO MIYATA AKIRA YOSHIOKA 《Pediatrics international》1994,36(1):91-94
This study reports an unusual case of acute leukemia which was diagnosed as hemophilia A on initial admission for leukemia. A 3 year old boy was admitted to Kagoshima University Hospital with anemia. He was diagnosed as acute lymphoblastic leukemia. At the same time he was revealed to have severe hemophilia A− without any previous episodes of severe bleeding tendency or family history of this disease. The laboratory investigation showed his mother to be a carrier of hemophilia A. Although there are many cases of hemophilia which have developed malignant tumors, most of them were caused by association with human immunodeficiency virus (HIV) infection. Only five cases with coexistence of leukemia and hemophilia without HIV infection have been reported and the present case is the first one in Japan. At this stage, hemophiliacs are not necessarily regarded to be a population at risk for the development of leukemia. Furthermore, no particular subtype of leukemia was characterized among these patients in the literature. 相似文献
9.
10.
HIROSHI INOUE KIYOSHI INOUE HIROSHI MATSUO KEIICHI KUWAKI TETSURO SHIRAI SATORU MURAO 《Pacing and clinical electrophysiology : PACE》1984,7(1):3-9
In two cases with recurrent sustained ventricular tachycardia (VT) due to re-entry, the response pattern to extrastimuli during the tachycardia was studied. In each case, right ventricular extrastimuli with longer coupling intervals during VT were followed by fully compensatory pauses and with shorter coupling intervals reset the tachycardia cycle. In one case, a plateau was produced by a single extrastimulus, resembling that seen in the response curve of sinus node automaticity as well as ectopic atrial tachycardia. Two successive stimuli produced three definite zones, i.e., fully compensatory, reset producing a plateau, and progressive prolongation zones with shortening of the coupling intervals between the two stimuli, and terminated the tachycardia with further shortening of the coupling intervals. In conclusion, resetting phenomenon was confirmed on two cases with re-entrant VT. This phenomenon cannot be used as a criterion to determine the mechanism responsible for VT. 相似文献