全文获取类型
收费全文 | 618篇 |
免费 | 61篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 3篇 |
妇产科学 | 1篇 |
基础医学 | 62篇 |
口腔科学 | 36篇 |
临床医学 | 68篇 |
内科学 | 118篇 |
皮肤病学 | 18篇 |
神经病学 | 85篇 |
特种医学 | 22篇 |
外科学 | 53篇 |
综合类 | 85篇 |
预防医学 | 28篇 |
眼科学 | 2篇 |
药学 | 52篇 |
2篇 | |
中国医学 | 20篇 |
肿瘤学 | 38篇 |
出版年
2024年 | 7篇 |
2023年 | 25篇 |
2022年 | 47篇 |
2021年 | 61篇 |
2020年 | 38篇 |
2019年 | 27篇 |
2018年 | 27篇 |
2017年 | 20篇 |
2016年 | 30篇 |
2015年 | 22篇 |
2014年 | 35篇 |
2013年 | 33篇 |
2012年 | 27篇 |
2011年 | 45篇 |
2010年 | 18篇 |
2009年 | 10篇 |
2008年 | 28篇 |
2007年 | 29篇 |
2006年 | 24篇 |
2005年 | 25篇 |
2004年 | 15篇 |
2003年 | 11篇 |
2002年 | 12篇 |
2001年 | 13篇 |
2000年 | 5篇 |
1999年 | 4篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 8篇 |
1989年 | 2篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有700条查询结果,搜索用时 15 毫秒
1.
Walid K. Abu Saleh Phillip Mason Odeaa Al Jabbari Hany Samir Brian A. Bruckner 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2015,42(6):569-571
The Impella 5.0, a percutaneously inserted left ventricular assist device, has been used to support patients who have severe heart failure or who are undergoing high-risk percutaneous coronary intervention. We report our surgical placement of the Impella 5.0, through a graft sewn to the aorta, to unload the left ventricle of a 59-year-old man who was undergoing venoarterial extracorporeal membrane oxygenation for postcardiotomy shock. The patient underwent successful placement of a long-term left ventricular assist device before his discharge from the hospital. The versatility of the Impella 5.0 is exemplified in this patient who was successfully bridged to long-term support. 相似文献
2.
Hao Wu Colin Webber Carmen Otero Fuentes Robert Bensen Karen Beattie Jonathan D Adachi Xiaoming Xie Farhang Jabbari David R Levy 《Journal l'Association canadienne des radiologistes》2007,58(3):167-175
OBJECTIVES: 1) To assess, with a peripheral magnetic resonance imaging system (pMRI), the prevalence of bony and soft tissue abnormalities in the knee joints of normal subjects, osteoarthritis (OA) patients, and individuals who have suffered an anterior cruciate ligament (ACL) rupture; and 2) to compare the prevalence among groups. METHODS: Magnetic resonance (MR) images of 28 healthy, 32 OA, and 26 ACL damaged knees were acquired with a 1.0-T pMRI system. Two radiologists graded the presence and severity of 9 MR image features: cartilage degeneration, osteophytes, subchondral cyst, bone marrow edema, meniscal abnormality, ligament integrity, loose bodies, popliteal cysts, and joint effusion. RESULTS: Ten of 28 healthy (35.7%), 24 of 26 ACL (92.3%), and all OA knees (100%) showed prevalent cartilage defects; 5 healthy (17.9%), 20 ACL (76.9%), and all OA knees (100%) had osteophytes; and 9 normal (32.1%), 21 ACL (80.8%), and 29 OA knees (90.6%) had meniscal abnormalities. One-half of the knees in the OA group (16 of 32, 50%) had subchondral cysts, and almost one-half had bone marrow edema (15 of 32, 46.9%). These features were not common in the ACL group (7.7%, and 11.5%, respectively) and were not observed in healthy knees. The OA group had the most severe cartilage defects, osteophytes, bone marrow edema, subchondral cysts, and meniscal abnormalities; the ACL group showed more severe cartilage defects, osteophytes, and meniscal abnormalities than did normal subjects. CONCLUSION: The results suggest that knees that have sustained ACL damage have OA-like reatures; most subjects (19 of 26, 73.1%) could be identified as in the early stage of OA. The prominent abnormalities present in ACL-damaged knees are cartilage defects, osteophytes, and meniscal abnormalities. 相似文献
3.
D Jabbari 《Journal of medical ethics》1990,16(1):35-40
It is a common feature of debates on the regulation of reproductive medicine to find law portrayed as a crude form of intervention consisting in the imposition of inflexible rules on doctors and medical researchers. This paper argues that this view must be replaced by a more accurate assessment of the law's potential role in the regulation of reproductive medicine. From an analysis of the White Paper on human fertilisation and embryology, and in particular the proposed Statutory Licensing Authority, the author contends that far from being an inflexible method of regulation law can foster discussion and compromise. 相似文献
4.
5.
Temenoff JS Park H Jabbari E Sheffield TL LeBaron RG Ambrose CG Mikos AG 《Journal of biomedical materials research. Part A》2004,70(2):235-244
Novel hydrogel materials based on oligo(poly(ethylene glycol) fumarate) (OPF) crosslinked with a redox radical initiation system were recently developed in our laboratory as injectable cell carriers for orthopedic tissue engineering applications. The effect of OPF hydrogel material properties on in vitro osteogenic differentiation of encapsulated rat marrow stromal cells (MSCs) with and without the presence of osteogenic supplements (dexamethasone) was investigated. Two OPF formulations that resulted in hydrogels with different swelling properties were used to encapsulate rat MSCs (seeding density approximately 13 million cells/mL, samples 6 mm diameter x 0.5 mm thick before swelling) and osteogenic differentiation in these constructs over 28 days in vitro was determined via histology and biochemical assays for alkaline phosphatase, osteopontin and calcium. Evidence of MSC differentiation was apparent over the culture period for samples without dexamethasone, but there was large variability in calcium production between constructs using cells of the same source. Differentiation was also seen in samples cultured with osteogenic supplements, but calcium deposition varied depending on the source pool of MSCs. By day 28, osteopontin and calcium results suggested that, in the presence of dexamethasone, OPF hydrogels with greater swelling promoted embedded MSC differentiation over those that swelled less (43.7 +/- 16.5 microg calcium/sample and 16.4 +/- 2.8 microg calcium/sample, respectively). In histological sections, mineralized areas were apparent in all sample types many microns away from the cells. These experiments indicate that OPF hydrogels are promising materials for use as injectable MSC carriers and that hydrogel swelling properties can influence osteogenic differentiation of encapsulated progenitor cells. 相似文献
6.
7.
利用Marmarou氏脑损伤动物模型,测定大鼠脑损伤后不同时间和部位的丙二醛(MDA)含量。结果示:损伤后1h,额叶、顶叶、脑干等处的MDA水平分别比对照组高出367%,418%和351%(P<0.01),并持续增高,伤后4h达高峰后缓慢下降,伤后24h仍明显高于对照组。纹状体、颞叶等处伤后1h的MDA水平升高较上述部位稍低,而分别较对照组升高169%和133%(P<0.01),伤后4h虽仍持续升高,但不超过35%。提示在大鼠弥漫性脑损伤后短期内即有自由基生成,几乎波及脑内各个部位,但程度不一。 相似文献
8.
Mary Feng Siavash Jabbari Alexander Lin Carol R Bradford Douglas B Chepeha Theodoros N Teknos Francis P Worden Christina Tsien Matthew J Schipper Gregory T Wolf Laura A Dawson Avraham Eisbruch 《Radiotherapy and oncology》2005,77(1):32-38
BACKGROUND AND PURPOSE: Predictive factors for local-regional (LR) failures after parotid-sparing, Intensity modulated (IMRT) or 3D conformal radiotherapy for head and neck (HN) cancers were assessed. PATIENTS AND METHODS: One hundred and fifty-eight patients with mostly stages III-IV HN squamous cell carcinoma underwent curative bilateral neck irradiation aimed at sparing the parotid glands. Patient, tumor, and treatment factors were analyzed as predictive factors for LR failure. RESULTS: Twenty-three patients had LR recurrence (19 in-field and four marginal). No differences were found in the doses delivered to the PTVs of patients with or without in-field recurrences. In univariate analysis, tumor site was highly predictive for LR failure in both postoperative and definitive RT patients. In postoperative RT patients, pathologic tumor size, margin status, extracapsular extension (ECE) and number of lymph node metastases, were also significantly predictive. Multivariate analysis showed tumor site (oropharynx vs. other sites) to be a significant predictor in all patients, and involved margins and number of involved lymph nodes in postoperative patients. CONCLUSIONS: Clinical rather than dosimetric factors predicted for LR failures in this series, and were similar to those reported following standard RT. These factors may aid in the selection of patients for studies of treatment intensification using IMRT. 相似文献
9.
The fibrillar structure and sub-micron diameter of electrospun nanofibers can be used to reproduce the morphology and structure
of the natural extracellular matrix (ECM). The objective of this work was to investigate the effect of fiber alignment on
osteogenic differentiation of bone marrow stromal (BMS) cells. Random and aligned poly(l-lactide) (PLLA) nanofibers were produced by collecting the spun fibers on a stationary plate and a rotating wheel, respectively,
as the ground electrode. Morphology and alignment of the BMS cells seeded on the fibers were characterized by SEM. The effect
of fiber orientation on osteogenic differentiation of BMS cells was determined by measuring alkaline phosphatase (ALPase)
activity, calcium content, and mRNA expression levels of osteogenic markers. There was a strong correlation between the fiber
and cell distributions for the random (p = 0.16) and aligned (p = 0.81) fibers. Percent deviation from ideal randomness (PDIR) values indicated that cells seeded on the random fibers (PDIR = 6.5%)
were likely to be distributed randomly in all directions while cells seeded on the aligned fibers (PDIR = 86%) were highly
likely to be aligned with the direction of fibers. BMS cell seeded on random and aligned fibers had similar cell count and
ALPase activity with incubation time, but the calcium content on aligned fibers was significantly higher after 21 days compared
to that of random fibers (p = 0.003). Osteopontin (OP) and osteocalcin (OC) expression levels of BMS cells on fibers increased with incubation time.
However, there was no difference between the expression levels of OP and OC on aligned vs. random fibers. The results indicate
that BMS cells aligned in the direction of PLLA fibers to form long cell extensions, and fiber orientation affected the extent
of mineralization, but it had no effect on cell proliferation or mRNA expression of osteogenic markers. 相似文献
10.
Qiang Fu Le Xu Yiwei Wang Qi Jiang Zheng Liu Junyu Zhang Quan Zhou Han Zeng Shanyou Tong Tao Wang Yangyang Qi Baoying Hu Hangcheng Fu Huyang Xie Lin Zhou Yuan Chang Yu Zhu Bo Dai Jiejie Xu 《European urology》2019,75(5):752-763