全文获取类型
收费全文 | 729篇 |
免费 | 56篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 40篇 |
妇产科学 | 7篇 |
基础医学 | 67篇 |
口腔科学 | 11篇 |
临床医学 | 64篇 |
内科学 | 160篇 |
皮肤病学 | 27篇 |
神经病学 | 31篇 |
特种医学 | 157篇 |
外科学 | 58篇 |
综合类 | 31篇 |
预防医学 | 34篇 |
眼科学 | 4篇 |
药学 | 77篇 |
中国医学 | 6篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 6篇 |
2022年 | 5篇 |
2021年 | 7篇 |
2019年 | 10篇 |
2018年 | 10篇 |
2017年 | 6篇 |
2016年 | 25篇 |
2015年 | 47篇 |
2014年 | 19篇 |
2013年 | 20篇 |
2012年 | 16篇 |
2011年 | 24篇 |
2010年 | 30篇 |
2009年 | 32篇 |
2008年 | 24篇 |
2007年 | 14篇 |
2006年 | 19篇 |
2005年 | 24篇 |
2004年 | 18篇 |
2003年 | 14篇 |
2002年 | 11篇 |
2001年 | 13篇 |
2000年 | 13篇 |
1999年 | 14篇 |
1998年 | 26篇 |
1997年 | 46篇 |
1996年 | 35篇 |
1995年 | 29篇 |
1994年 | 22篇 |
1993年 | 20篇 |
1992年 | 5篇 |
1991年 | 9篇 |
1990年 | 11篇 |
1989年 | 22篇 |
1988年 | 18篇 |
1987年 | 13篇 |
1986年 | 13篇 |
1985年 | 9篇 |
1984年 | 9篇 |
1983年 | 15篇 |
1982年 | 12篇 |
1981年 | 9篇 |
1980年 | 7篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1956年 | 2篇 |
1955年 | 2篇 |
1946年 | 2篇 |
1930年 | 2篇 |
排序方式: 共有795条查询结果,搜索用时 15 毫秒
1.
2.
3.
Assessment of cutaneous sensory and autonomic axon reflexes in rheumatoid arthritis. 总被引:1,自引:1,他引:0
下载免费PDF全文
![点击此处可从《Annals of the rheumatic diseases》网站下载免费的PDF全文](/ch/ext_images/free.gif)
OBJECTIVE--To assess sensory function in skin overlying the joints of patients with rheumatoid arthritis, in relation to the pain and tenderness which commonly arises in structures not directly involved in the inflammatory process. METHODS--An intradermal injection of capsaicin 0.05 microgram in 10 microliters was made over the wrists and forearms of 40 patients with rheumatoid arthritis and 46 control subjects. Axon reflex vasodilatation was measured using laser Doppler flowmetry. Cholinergic sympathetic function was assessed by measuring axon reflex sweating induced by a single intradermal injection of nicotine 0.5 microgram in 0.1 ml. RESULTS--Capsaicin induced axon reflex vasodilation over the wrists was found to decrease with age in normal subjects (r = -0.62, p < 0.001). In patients with rheumatoid arthritis, capsaicin induced axon reflex vasodilatation was significantly greater over the wrists, but not the forearms, when compared with age matched normal controls (p < 0.01). A minimal correlation between axon reflex vasodilatation and visual analogue pain score was apparent in the rheumatoid group (r = -0.37, p < 0.05). Nicotine induced sweating responses were similar in the rheumatoid and normal groups, and both showed a linear age related decline. CONCLUSIONS--The results show a selective increase of capsaicin induced vasodilatation in skin overlying joints in patients with rheumatoid arthritis. This suggests that the activity of a sub-population of periarticular small sensory fibres is altered, which may explain, at least in part, some of the clinical findings in this disorder. 相似文献
4.
Hausegger KA; Cragg AH; Lammer J; Lafer M; Fluckiger F; Klein GE; Sternthal MH; Pilger E 《Radiology》1994,190(1):199
5.
6.
7.
8.
9.
10.
CP Schaecher KA Groesch 《American journal of reproductive immunology (New York, N.Y. : 1989)》2006,55(6):405-405
Background: Control of mRNA stability is an essential regulatory process in eukaryotic gene expression. HuR, a 3'UTR mRNA binding protein, can protect AU-rich mRNA from degradation in response to stresses. PlGF, an angiogenic growth factor, contains two consensus AU-rich sites suggesting that under normal conditions HuR may protect PlGF mRNA from degradation. Trophoblast expression of PlGF is significantly decreased in preeclampsia and by hypoxia in vitro . We hypothesize that decreased levels of cytoplasmic HuR may contribute to decreased PlGF expression in hypoxic and preeclamptic trophoblast.
Methods: Western blots were used to determine relative effects of in vitro hypoxia on HuR protein expression and subcellular localization in trophoblast. Immunohistochemistry was used to compare HuR expression patterns in trophoblast of preeclamptic and normal placentae.
Results: Cytoplasmic expression of HuR was decreased 1.4 fold in the cytoplasm and 1.2 fold in the nucleus of JEG3 cells. A shift in HuR was more apparent in primary trophoblast with a greater than 2-fold decrease in the cytoplasm and a 1.4 fold decrease in the nucleus following 24 hr of hypoxia. Immunohistochemical analyses detected HuR expression in near term trophoblast in situ . However, this technical approach did not detect a significant change in HuR expression between normal and preeclamptic trophoblast.
Conclusions: HuR expression is decreased in hypoxic trophoblast, at least in vitro , which may provide a causal link to decreased PlGF mRNA expression. Down regulation of trophoblast PlGF expression is thought to contribute to the pathophysiology associated with preeclampsia including the relative lack of perfusion of the placenta and systemic renal effects. 相似文献
Methods: Western blots were used to determine relative effects of in vitro hypoxia on HuR protein expression and subcellular localization in trophoblast. Immunohistochemistry was used to compare HuR expression patterns in trophoblast of preeclamptic and normal placentae.
Results: Cytoplasmic expression of HuR was decreased 1.4 fold in the cytoplasm and 1.2 fold in the nucleus of JEG3 cells. A shift in HuR was more apparent in primary trophoblast with a greater than 2-fold decrease in the cytoplasm and a 1.4 fold decrease in the nucleus following 24 hr of hypoxia. Immunohistochemical analyses detected HuR expression in near term trophoblast in situ . However, this technical approach did not detect a significant change in HuR expression between normal and preeclamptic trophoblast.
Conclusions: HuR expression is decreased in hypoxic trophoblast, at least in vitro , which may provide a causal link to decreased PlGF mRNA expression. Down regulation of trophoblast PlGF expression is thought to contribute to the pathophysiology associated with preeclampsia including the relative lack of perfusion of the placenta and systemic renal effects. 相似文献