全文获取类型
收费全文 | 971篇 |
免费 | 83篇 |
国内免费 | 28篇 |
专业分类
儿科学 | 30篇 |
妇产科学 | 15篇 |
基础医学 | 97篇 |
口腔科学 | 14篇 |
临床医学 | 70篇 |
内科学 | 152篇 |
皮肤病学 | 33篇 |
神经病学 | 26篇 |
特种医学 | 158篇 |
外科学 | 56篇 |
综合类 | 145篇 |
预防医学 | 74篇 |
眼科学 | 1篇 |
药学 | 163篇 |
1篇 | |
肿瘤学 | 47篇 |
出版年
2023年 | 6篇 |
2021年 | 6篇 |
2020年 | 7篇 |
2018年 | 12篇 |
2017年 | 14篇 |
2016年 | 18篇 |
2015年 | 12篇 |
2014年 | 25篇 |
2013年 | 34篇 |
2012年 | 36篇 |
2011年 | 24篇 |
2010年 | 34篇 |
2009年 | 39篇 |
2008年 | 40篇 |
2007年 | 46篇 |
2006年 | 33篇 |
2005年 | 23篇 |
2004年 | 34篇 |
2003年 | 23篇 |
2002年 | 20篇 |
2001年 | 21篇 |
2000年 | 28篇 |
1999年 | 19篇 |
1998年 | 46篇 |
1997年 | 45篇 |
1996年 | 41篇 |
1995年 | 29篇 |
1994年 | 23篇 |
1993年 | 24篇 |
1992年 | 17篇 |
1991年 | 9篇 |
1990年 | 13篇 |
1989年 | 29篇 |
1988年 | 23篇 |
1987年 | 18篇 |
1986年 | 27篇 |
1985年 | 22篇 |
1984年 | 14篇 |
1983年 | 8篇 |
1982年 | 21篇 |
1981年 | 13篇 |
1980年 | 13篇 |
1979年 | 10篇 |
1978年 | 13篇 |
1977年 | 14篇 |
1976年 | 15篇 |
1975年 | 8篇 |
1974年 | 4篇 |
1969年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有1082条查询结果,搜索用时 15 毫秒
1.
2.
S Gunasti† SS Marakli† I Tuncer‡ N Ozpoyraz§ VL Aksungur† 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):811-817
BACKGROUND: We have seen several patients with itchy lichenified plaques located bilaterally on the elbows and/or knees and have named this condition 'psoriatic neurodermatitis' (PN). OBJECTIVE: The purpose of this study was to compare clinical and histopathological characteristics of these patients to those of patients with typical lichen simplex chronicus (LSC). METHODS: Nineteen patients with PN and 34 patients with typical LSC were included. Besides clinical dermatological evaluation, the prick test was carried out on 49 patients; the Phadiatop test on 40 patients; the patch test with European standard series on 47 patients; histopathological evaluation on 39 patients; and clinical psychiatric examination on 38 patients. RESULTS: Almost exclusively, PN was seen in females and was located on the extremities. It caused more plaques than typical LSC did. In PN, the plaques were smaller, sharper, more keratotic and less excoriated, and had fewer lichenoid papules around them. Itching was usually more severe in the evening, while resting and in a hot environment in typical LSC, but not in PN. In plaques of PN, microabscesses in the horny layer, hypogranulosis, regular acanthosis and thinning of the suprapapillary plates were more frequent, and hyperpigmentation in the basal layer was less. In patients with PN, depressive disorder was found more frequently; and generalized anxiety disorder or psychosomatic characteristics, less. There were no significant differences in the results of prick, Phadiatop and patch tests between patients with PN and those with typical LSC. CONCLUSION: In our opinion, it is most likely that the so-called PN is itchy psoriasis superimposed by LSC. 相似文献
3.
4.
In a 10-year (1979-1988) follow-up study of young insulin-dependent diabetics carried out at Group Health Cooperative of Puget Sound, the frequency of hospitalization for hypoglycemia remained constant. During the early years only animal insulins were available; during the latter years, human insulins were used in a majority of patients. The adjusted relative risk estimate for hospitalizations for hypoglycemia comparing users of human with users of animal insulins was 0.6 (95% confidence interval 0.2, 2.3). We conclude that the use of human insulins is not associated with an increased risk of hospitalization for hypoglycemia as compared with animal insulins in this population. 相似文献
5.
Ten thrombocytopenic patients (platelets < 10–24 × 10(9)/L) who were refractory to platelet transfusion were investigated for their responsiveness to staphylococcal protein A column therapy. Nine patients had previously been treated with steroids, intravenous immune globulin, and/or other forms of immunosuppressive therapy without improvement in their transfusion response. All patients were receiving multiple platelet transfusions without achieving 1-hour corrected count increments (CCIs) > or = 7500. Eight patients had antibodies that reacted with platelets and were directed against HLA class I antigens, ABO antigens, and/or platelet-specific alloantigens. Plasma (500-2000 mL) from each patient was passed over a protein A silica gel column and then returned to the patient. Patients received from 1 to 14 treatments. A positive response to protein A therapy was defined as at least a doubling of the pretreatment platelet count and/or two successive 10- to 120-minute posttransfusion CCIs > or = 7500. Following plasma treatments, 6 of 10 patients responded with daily platelet counts that averaged 48 +/− 11 × 10(9) per L as compared with counts of 16 +/− 7 × 10(9) per L (p < 0.0005) before treatment. Posttransfusion CCI values determined in four of these patients averaged 2480 +/− 810 and 10,010 +/− 3540 (p < 0.005) before and after treatment, respectively. In contrast, among the four unresponsive patients, platelet counts averaged 10 +/− 9 and 13 +/− 10 × 10(9) per L (p = NS), respectively, while posttransfusion CCIs were 700 +/− 1410 and 1520 +/− 2460 (p = NS), respectively.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
6.
7.
Hershel Jick M.D. Marian Wald Myers P.A.-C. Alan D. Dean M.B. B.S. 《Pharmacotherapy》1995,15(2):176-181
Sulfasalazine (SASP) has often been reported to cause serious blood disorders, particularly agranulocytosis; however, little quantitative information is available to estimate the risk or to identify possible modifiers of the risk. We used comprehensive clinical information recorded on office computers by selected general practitioners in Britain to conduct a follow-up study of some 10,000 users of SASP and some 4000 users of mesalazine to estimate the risk of blood disorders associated with these drugs. Overall, the frequency of blood disorders attributable to SASP was 27/10,332 (2.6/1000 users). The risk for SASP users who were treated for arthritic disorders (6.1/1000 users) was some 10 times higher than that for users who were treated for inflammatory bowel disease (0.6/1000 users). There were no cases of blood disorders in users of mesalazine. 相似文献
8.
9.
Dr. Hershel Jick M.D. Dr. Laura E. Derby D.Sc. Dr. Victor Gurewich M.D. Mr. Catherine Vasilakis M.P.H. 《Pharmacotherapy》1996,16(3):321-326
We conducted a case-control study based on computer-recorded information accrued in the United Kingdom General Practice Research Database to assess and compare the relation between different antihypertensive drug therapies and myocardial infarction in patients with no known clinical or laboratory risk factors for myocardial infarction other than hypertension. Cases were treated hypertensive patients with no other known risk factors who developed a first acute myocardial infarction between January 1, 1993, and October 31, 1994. They were ascertained from a review of the clinical record together with a questionnaire filled out by the attending general practitioner. Controls were matched to each case for age, sex, general practice, and index date. Antihypertensive therapy was derived from the computerized patient record. The study consisted of 210 cases and 793 controls. Compared with users of β-blockers alone, the adjusted relative risk (RR) estimates for all other treatment regimens were close to 1.0. A comparison of users of calcium channel blockers alone with users of β-blockers alone yielded a RR estimate of 0.9 (95% CI 0.5, 1.7). We conclude that the risk of acute myocardial infarction in otherwise healthy, treated hypertensive patients is not materially associated with the particular drug they receive. 相似文献
10.