全文获取类型
收费全文 | 4645篇 |
免费 | 459篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 52篇 |
儿科学 | 105篇 |
妇产科学 | 169篇 |
基础医学 | 673篇 |
口腔科学 | 105篇 |
临床医学 | 479篇 |
内科学 | 1008篇 |
皮肤病学 | 65篇 |
神经病学 | 314篇 |
特种医学 | 169篇 |
外科学 | 619篇 |
综合类 | 62篇 |
一般理论 | 3篇 |
预防医学 | 506篇 |
眼科学 | 81篇 |
药学 | 370篇 |
中国医学 | 13篇 |
肿瘤学 | 328篇 |
出版年
2023年 | 55篇 |
2022年 | 83篇 |
2021年 | 153篇 |
2020年 | 92篇 |
2019年 | 111篇 |
2018年 | 142篇 |
2017年 | 114篇 |
2016年 | 114篇 |
2015年 | 146篇 |
2014年 | 194篇 |
2013年 | 253篇 |
2012年 | 375篇 |
2011年 | 381篇 |
2010年 | 198篇 |
2009年 | 168篇 |
2008年 | 301篇 |
2007年 | 308篇 |
2006年 | 281篇 |
2005年 | 286篇 |
2004年 | 274篇 |
2003年 | 243篇 |
2002年 | 206篇 |
2001年 | 41篇 |
2000年 | 23篇 |
1999年 | 27篇 |
1998年 | 41篇 |
1997年 | 26篇 |
1996年 | 21篇 |
1995年 | 25篇 |
1994年 | 26篇 |
1993年 | 31篇 |
1992年 | 25篇 |
1991年 | 19篇 |
1990年 | 23篇 |
1989年 | 19篇 |
1988年 | 11篇 |
1987年 | 13篇 |
1986年 | 18篇 |
1985年 | 17篇 |
1984年 | 28篇 |
1983年 | 17篇 |
1982年 | 21篇 |
1981年 | 23篇 |
1980年 | 18篇 |
1979年 | 15篇 |
1978年 | 13篇 |
1977年 | 12篇 |
1975年 | 11篇 |
1974年 | 11篇 |
1973年 | 8篇 |
排序方式: 共有5121条查询结果,搜索用时 0 毫秒
1.
2.
The use of computer technology for patient education has increased in recent years. This article describes a study that measures the attitudes and perceptions of healthcare professionals and laypeople regarding the effectiveness of a multimedia computer, the Brain Injury Resource Center? (BIRC), as an educational tool. The study focused on three major themes: (a) usefulness of the information presented, (b) effectiveness of the multimedia touch-screen computer methodology, and (c) the appropriate time for making this resource available. This prospective study, conducted in an acute care medical center, obtained healthcare professionals' evaluations using a written survey and responses from patients with brain injury and their families during interviews. The findings have yielded excellent ratings as to the ease of understanding and usefulness of the BIRC. By using sight, sound, and touch, such a multimedia learning center has the potential to simplify patient and family education. 相似文献
3.
Geert Verreck Annelies Decorte Koen Heymans Jef Adriaensen Dirk Cleeren Adri Jacobs Dehua Liu David Tomasko Albertina Arien Jef Peeters Patrick Rombaut Guy Van den Mooter Marcus E Brewster 《European journal of pharmaceutical sciences》2005,26(3-4):349-358
The aim of the current research project was to explore the possibilities of combining pressurized carbon dioxide with hot stage extrusion during manufacturing of solid dispersions of itraconazole and polyvinylpyrrolidone-co-vinyl acetate 64 (PVP-VA 64) and to evaluate the ability of the pressurized gas to act as a temporary plasticizer as well as to produce a foamed extrudate. Pressurized carbon dioxide was injected into a Leistritz Micro 18 intermeshing co-rotating twin-screw melt extruder using an ISCO 260D syringe pump. The physicochemical characteristics of the extrudates with and without injection of carbon dioxide were evaluated with reference to the morphology of the solid dispersion and dissolution behaviour and particle properties. Carbon dioxide acted as plasticizer for itraconazole/PVP-VA 64, reducing the processing temperature during the hot stage extrusion process. Amorphous dispersions were obtained and the solid dispersion was not influenced by the carbon dioxide. Release of itraconazole from the solid dispersion could be controlled as a function of processing temperature and pressure. The macroscopic morphology changed to a foam-like structure due to expansion of the carbon dioxide at the extrusion die. This resulted in increased specific surface area, porosity, hygroscopicity and improved milling efficiency. 相似文献
4.
Healthcare information systems (HISs) are often implemented to enhance the quality of care and the degree to which it is patient-centered,
as well as to improve the efficiency and safety of services. However, the outcomes of HIS implementations have not met expectations.
We set out to organize the knowledge gained in qualitative studies performed in association with HIS implementations and to
use this knowledge to outline an updated structure for implementation planning. A multi-disciplinary team performed the analyses
in order to cover as many aspects of the primary studies as possible. We found that merely implementing an HIS will not automatically
increase organizational efficiency. Strategic, tactical, and operational actions have to be taken into consideration, including
management involvement, integration in healthcare workflow, establishing compatibility between software and hardware and,
most importantly, user involvement, education and training. The results should be interpreted as a high-order scheme, and
not a predictive theory. 相似文献
5.
6.
Sociodemographic Differences in the Prevalence of Self-Reported Headache in Icelandic School-Children 总被引:1,自引:0,他引:1
Gúdrun Kristjánsdóttir R.N. M.Sc. Vivian Wahlberg R.N. Dr. Med. Sc. Professor 《Headache》1993,33(7):376-380
SYNOPSIS
The study considers the prevalence of headache experiences in a random national sample of 2140 Icelandic 11-12 and 15-16 year-old school-children. The study finds an overall 21.9% prevalence of "at least weekly" headache. The prevalence is significantly higher among younger children end among girls. The gender difference is found to be related to the fact that older boys have a markedly lower prevalence than younger boys. No gender difference is observed in the younger group. Social class interacts with gender, with the gender difference leveling out in the upper class. The frequency of headache experiences correlates with last months use of medication to relieve headache. The high overall prevalence of headache found in this study agrees with earlier findings, and is a matter of concern since little is being done to counter this problem of discomfort among school-children. 相似文献
The study considers the prevalence of headache experiences in a random national sample of 2140 Icelandic 11-12 and 15-16 year-old school-children. The study finds an overall 21.9% prevalence of "at least weekly" headache. The prevalence is significantly higher among younger children end among girls. The gender difference is found to be related to the fact that older boys have a markedly lower prevalence than younger boys. No gender difference is observed in the younger group. Social class interacts with gender, with the gender difference leveling out in the upper class. The frequency of headache experiences correlates with last months use of medication to relieve headache. The high overall prevalence of headache found in this study agrees with earlier findings, and is a matter of concern since little is being done to counter this problem of discomfort among school-children. 相似文献
7.
Vivian E. von Gruenigen M.D. Joseph T. Santoso M.D. Robert L. Coleman M.D. Carolyn Y. Muller M.D. David Scott Miller M.D. J.Michael Mathis Ph.D. 《Gynecologic oncology》1998,69(3):197-204
Objectives.To test the safety, efficacy, and toxicity of gene therapy using wild-type p53-expressing adenovirus (Ad-CMV-p53) in a nude mouse model with intraperitoneal (ip) 2774 human ovarian cancer cell line that contains a p53 mutation.Study design.An initial study of adenovirus tolerance was determined in nude mice by a single ip injection of increasing doses of Ad-CMV-p53. Nude mice were implanted with an LD100dose of 1 × 107cells. To study the efficacy and specificity of Ad-CMV-p53 treatment, the mice received treatment with different adenovirus constructs. One group received Ad-CMV-p53 and another group received a control adenovirus construct, Ad-CMV-βgal. To study the treatment response to Ad-CMV-p53, the mice were divided into groups and received various treatment schedules of 1 × 108pfu of Ad-CMV-p53.Results.The mice tolerated Ad-CMV-p53 without adverse effects at doses of 1 × 108pfu. The response to Ad-CMV-p53 showed significant survival duration in each dose regimen, with a survival time greater than that of untreated animals (P= 0.0173). However, no statistically significant survival advantage was observed between Ad-CMV-p53- and Ad-CMV-βgal-treated mice.Conclusions.These studies show that at the adenovirus dose and administration regimen used, there is effective but not specific 2774 tumor growth inhibitionin vivo.Efficient introduction of biologically active genes into tumor cells would greatly facilitate cancer therapy. Thus, although promising, these results caution that much effort will be required to realize the potential for clinical application of adenovirus-based ovarian cancer gene therapy. 相似文献
8.
Dental abnormalities cause problems for both dentist and anaesthetist. The anaesthetic hazards associated with the 'passion gap'--a term used in the western Cape Province for removal of the top four incisor teeth, a practice widespread among members of the Cape Coloured community--are discussed. Recommendations are made to assist the anaesthetist when dealing with such a patient. 相似文献
9.
The relationship of drinking and birth outcome in a US national sample of expectant mothers 总被引:3,自引:0,他引:3
Vivian B. Faden Barry I. Graubard & Mary Dufour 《Paediatric and perinatal epidemiology》1997,11(2):167-180
Alcohol consumption by pregnant women and birth outcome were studied in 9953 livebirths, 3309 fetal deaths and 5332 infant deaths from the 1988 National Maternal and Infant Health Survey. In crude analyses, race, age, mother's education, prenatal care, parity, low birthweight, gestational age, smoking and alcohol consumption during pregnancy were significantly related to the occurrence of fetal deaths and infant deaths. Among women having livebirths, race, age, mother's education, prenatal care, prematurity, gestational age, smoking and alcohol consumption during pregnancy were significantly related to having a low birthweight baby (< 2500 g). In this group, women who drank more during pregnancy also smoked more, were younger and less educated than women who drank at lower levels or not at all. The relationship of alcohol consumption during pregnancy and infant birthweight for those women having livebirths was studied using multivariable linear regression. The results indicated that race, mother's education, baby's sex, parity, mother's height, mother's body mass index and smoking, but not alcohol consumption, were significantly related to birthweight. Multivariable logistic regressions were performed for the occurrence of low birthweight, fetal death and infant death. The effect of alcohol was significant in all these analyses. These results indicate that alcohol has an important relationship with birth outcome, but that for the drinking reported in this study, the alcohol effect on mean birthweight is small relative to that of other risk factors, accounting for the non-significant result in the multiple linear regression. 相似文献
10.