排序方式: 共有6条查询结果,搜索用时 12 毫秒
1
1.
Takkavatakarn Kullaya Wuttiputhanun Thunyatorn Phannajit Jeerath Praditpornsilpa Kearkiat Eiam-Ong Somchai Susantitaphong Paweena 《International urology and nephrology》2022,54(2):309-321
International Urology and Nephrology - The heightened fibroblast growth factor 23 (FGF23) level in patients with chronic kidney disease (CKD) is associated with increased cardiovascular disease and... 相似文献
2.
Kullaya Takkavatakarn Pongpratch Puapatanakul Jeerath Phannajit Warumphon Sukkumme Pajaree Chariyavilaskul Patita Sitticharoenchai Asada Leelahavanichkul Pisut Katavetin Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong 《Toxins》2021,13(10)
P-cresyl sulfate and indoxyl sulfate are strongly associated with cardiovascular events and all-cause mortality in chronic kidney disease (CKD). This randomized controlled trial was conducted to compare the effects between sevelamer and calcium carbonate on protein-bound uremic toxins in pre-dialysis CKD patients with hyperphosphatemia. Forty pre-dialysis CKD patients with persistent hyperphosphatemia were randomly assigned to receive either 2400 mg of sevelamer daily or 1500 mg of calcium carbonate daily for 24 weeks. A significant decrease of total serum p-cresyl sulfate was observed in sevelamer therapy compared to calcium carbonate therapy (mean difference between two groups −5.61 mg/L; 95% CI −11.01 to −0.27 mg/L; p = 0.04). There was no significant difference in serum indoxyl sulfate levels (p = 0.36). Sevelamer had effects in terms of lowering fibroblast growth factor 23 (p = 0.01) and low-density lipoprotein cholesterol levels (p = 0.04). Sevelamer showed benefits in terms of retarding CKD progression. Changes in vascular stiffness were not found in this study. 相似文献
3.
Kawintharat Harirugsakul Sorawit Wainipitapong Jeerath Phannajit Leilani Paitoonpong Kavirach Tantiwongse 《Translational andrology and urology》2021,10(12):4376
BackgroundErectile dysfunction (ED) is suspected to be the symptom manifestation of COVID-19. However, scarce data was presented this day. Our study was conducted to determine the prevalence of ED and its associated factors among Thai patients with COVID-19.MethodsSexually active males with COVID-19, hospitalized between May and July 2021 at one university hospital in Bangkok, were screened for erectile dysfunction by the International Index of Erectile Function 5 (IIEF-5). Demographic data and COVID-19 treatment history were collected. Mental health status, including depression and anxiety, was evaluated with the Thai Patient Health Questionnaire 9 (PHQ-9) and the Generalized Anxiety Disorder Scale (GAD-7), respectively. The sample size was calculated, and logistic regression was used to analyze the association.ResultsOne hundred fifty-three men with COVID-19 were recruited. ED prevalence was 64.7%, of which severity was mostly mild. Logistic regression, adjusted for age, BMI, and medical comorbidities, portrayed a significant association between ED and mental health status. Higher risk of ED was found in participants with major depression [adjusted OR 8.45, 95% CI: 1.01–70.96, P=0.049] and higher GAD-7 total score [adjusted OR 1.15, 95% CI: 1.01–1.31, P=0.039].ConclusionsThai patients with COVID-19 had high prevalence of ED, which was associated with mental disorders. Thus, screening for mental problems is recommended in individuals with COVID-19 and ED. 相似文献
4.
Sarinya Boongird Jeerath Phannajit Talerngsak Kanjanabuch Piyatida Chuengsaman Phongsak Dandecha Guttiga Halue Pichet Lorvinitnun Chanchana Boonyakrai Worapot Treamtrakanpon Sajja Tatiyanupanwong Niwat Lounseng Jeffrey Perl David W. Johnson Roberto Pecoits-Filho Suchai Sritippayawan Kriang Tungsanga Surasak Kantachuvesiri Vuddhidej Ophascharoensuk Thailand PDOPPS Steering Committee Advisory Board of Peritoneal Dialysis The Nephrology Society of Thailand 《Nephrology (Carlton, Vic.)》2023,28(Z1):14-23
Aim
To assess whether the peritoneal dialysis (PD) centres included in the Peritoneal Dialysis Outcomes and Practise Patterns Study (PDOPPS) in Thailand are representative of other PD centres in the country, based on 8 key performance indicators (KPIs 1–8).Methods
A retrospective analysis was conducted comparing PD-related clinical outcomes between PD centres included in the PDOPPS (the PDOPPS group) and those not included (the non-PDOPPS group) from January 2018 to December 2019. Logistic regression analysis was used to identify predictors associated with achieving the target KPIs.Results
Of 181 PD centres, 22 (12%) were included in the PDOPPS. PD centres in the PDOPPS group were larger and tended to serve more PD patients than those in the non-PDOPPS group. However, the process and outcome KPIs (KPIs 1–8) were comparable between the 2 groups. Large hospitals (≥120 beds), providing care to ≥100 PD cases and having experience for >10 years were independent predictors of achieving the peritonitis rate target of <0.5 episodes/year. Most PD centres in Thailand showed weaknesses in off-target haemoglobin levels and culture-negative peritonitis rate.Conclusions
The PD centres included in Thai PDOPPS were found to be representative of other PD centres in Thailand in terms of clinical outcomes. Thus, Thai PDOPPS findings may apply to the broader PD population in Thailand. 相似文献5.
6.
Guttiga Halue Huttaporn Tharapanich Jeerath Phannajit Talerngsak Kanjanabuch Athiphat Banjongjit Pichet Lorvinitnun Suchai Sritippayawan Wichai Sopassathit Ussanee Poonvivatchaikarn Somphon Buranaosot Wanida Somboonsilp Pimpong Wongtrakul Chanchana Boonyakrai Surapong Narenpitak Sajja Tatiyanupanwong Wadsamon Saikong Sriphrae Uppamai Setthapon Panyatong Rutchanee Chieochanthanakij Niwat Lounseng Angsuwarin Wongpiang Worapot Treamtrakanpon Peerapach Rattanasoonton Narumon Lukrat Phichit Songviriyavithaya Uraiwan Parinyasiri Piyarat Rojsanga Patnarin Kanjanabuch Pongpratch Puapatanakul Krit Pongpirul David W. Johnson Jeffrey Perl Roberto Pecoits-Filho Vuddhidej Ophascharoensuk Kriang Tungsanga Thailand PDOPPS Steering Committee 《Nephrology (Carlton, Vic.)》2023,28(Z1):35-47
Background
Patient-reported outcome measures (PROMs) are widely recognized as valuable predictors of clinical outcomes in peritoneal dialysis (PD). Our study aimed to explore the connections between patient-reported constipation and clinical outcomes.Methods
We assessed constipation in patients across 22 facilities participating in the Thailand Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) from 2014 to 2017. Constipation diagnosis utilized objective assessment tools such as the Bristol stool form scale (BSFS) and a self-reported questionnaire known as the constipation severity score (CSS). The BSFS is a 7-level scale that visually inspects feces based on texture and morphology, while the CSS measures constipation duration and severity using a 5-point Likert scale for various factors. We employed Cox proportional hazards model regression to determine the associations between constipation and clinical outcomes, including mortality, hemodialysis (HD) transfer and peritonitis.Results
Among 975 randomly selected PD patients from 22 facilities, 845 provided written informed consent, and 729 completed CSS questionnaire. Constipation was prevalent in the PD population (13%), particularly among older patients, those who were caregiver dependent, had diabetes and poorer nutritional status (indicated by lower time-averaged serum albumin, potassium, creatinine and phosphate concentrations). Twenty-seven percent of which experiencing symptoms of constipation for over a year. Notably, self-reported constipation at baseline was significantly associated with a shorter time to first peritonitis and higher rates of peritonitis and death. However, no significant association was found between constipation and HD transfer after adjusting for various factors, including age, gender, PD vintage, comorbidities, shared frailty by study sites and serum albumin.Conclusion
Patient-reported constipation independently correlated with increased risks of peritonitis and all-cause mortality, though no such correlation was observed with HD transfer. These findings underscore the need for further investigation to identify effective interventions for constipation in PD patients. 相似文献
1