全文获取类型
收费全文 | 25443篇 |
免费 | 1779篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 324篇 |
儿科学 | 488篇 |
妇产科学 | 545篇 |
基础医学 | 3302篇 |
口腔科学 | 473篇 |
临床医学 | 2959篇 |
内科学 | 5181篇 |
皮肤病学 | 393篇 |
神经病学 | 2190篇 |
特种医学 | 940篇 |
外科学 | 4331篇 |
综合类 | 187篇 |
一般理论 | 50篇 |
预防医学 | 1946篇 |
眼科学 | 600篇 |
药学 | 1698篇 |
中国医学 | 33篇 |
肿瘤学 | 1643篇 |
出版年
2024年 | 30篇 |
2023年 | 268篇 |
2022年 | 475篇 |
2021年 | 1089篇 |
2020年 | 553篇 |
2019年 | 920篇 |
2018年 | 1017篇 |
2017年 | 738篇 |
2016年 | 779篇 |
2015年 | 881篇 |
2014年 | 1308篇 |
2013年 | 1472篇 |
2012年 | 2391篇 |
2011年 | 2418篇 |
2010年 | 1235篇 |
2009年 | 1126篇 |
2008年 | 1723篇 |
2007年 | 1701篇 |
2006年 | 1509篇 |
2005年 | 1394篇 |
2004年 | 1186篇 |
2003年 | 1065篇 |
2002年 | 898篇 |
2001年 | 144篇 |
2000年 | 113篇 |
1999年 | 99篇 |
1998年 | 120篇 |
1997年 | 83篇 |
1996年 | 49篇 |
1995年 | 31篇 |
1994年 | 35篇 |
1993年 | 29篇 |
1992年 | 42篇 |
1991年 | 35篇 |
1990年 | 21篇 |
1989年 | 43篇 |
1988年 | 27篇 |
1987年 | 20篇 |
1986年 | 17篇 |
1985年 | 28篇 |
1984年 | 15篇 |
1983年 | 24篇 |
1982年 | 16篇 |
1981年 | 13篇 |
1980年 | 12篇 |
1979年 | 13篇 |
1975年 | 8篇 |
1974年 | 6篇 |
1971年 | 5篇 |
1968年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
Gregory Guldner MD MS Jason Schultz BS Perry Sexton MD Corwyn Fortner BS Mark Richmond MD 《Academic emergency medicine》2003,10(2):134-139
OBJECTIVES: Physicians commonly use etomidate for adult rapid-sequence intubation (RSI), but the manufacturer does not recommend its use for children under 10 years of age due to a lack of data. The authors present their experience with etomidate for pediatric RSI in order to further develop its risk-benefit profile in this age group. METHODS: Trained abstractors reviewed the medical records for all children under 10 years old who received etomidate for RSI between July 1996 and April 2001. RESULTS: 105 children, with an average age of 3 (+/-2.9) years, received a median dose of 0.32 (+/-0.12) mg/kg of etomidate. The systolic blood pressure increased an average of 4 mm Hg (95% CI = -3.3 to 9.2); the diastolic blood pressure increased 7 mm Hg (95% CI = -3.1 to 11) within 10 minutes of receiving etomidate. The heart rate increased an average of 10 beats/min (95% CI = 4.0 to 17.4). Complications included three patients who vomited within 10 minutes of etomidate administration. There were no cases of documented myoclonus, status epilepticus, or new-onset seizures. Thirty-eight patients received corticosteroids during the hospital course, none for suspected adrenal insufficiency. Three patients died, all from severe brain injury. CONCLUSIONS: In children less than 10 years old, etomidate seems to produce minimal hemodynamic changes, and appears to have a low risk of clinically important adrenal insufficiency, myoclonus, and status epilepticus. The association between etomidate and emesis (observed in less than 3% of enrolled patients) remains unclear. For clinical situations in which minimal blood pressure changes during RSI are critical, etomidate appears to have a favorable risk-benefit profile for children under 10 years old. 相似文献
10.
Hugo Maia Julio Casoy Tania Correia Luís Freitas Kleber Pimentel Célia Athayde Elsimar Coutinho 《Gynecological endocrinology》2006,22(10):547-551
OBJECTIVES: To determine whether aromatase expression in the eutopic endometrium and adenomyotic foci is affected by previous use of oral contraceptives containing gestodene, and to determine whether changes in cyclooxygenase-2 (COX-2) expression occur in adenomyosis during the menstrual cycle. PATIENT AND METHODS: This was a retrospective cohort study carried out in paraffin-embedded endometrial tissue obtained from patients with a histological diagnosis of adenomyosis obtained during the proliferative (n = 25) and luteal (n = 10) phases of the menstrual cycle and following the use of continuous oral contraception with gestodene/ethinyl estradiol (n = 7). COX-2 and aromatase expression were measured in both eutopic endometrium and adenomyotic foci using immunohistochemical methods. RESULTS: Aromatase expression was detected in 80% of the endometrial slices by immunohistochemistry. In positive cases, aromatase was mainly detected in the stromal cells of the eutopic endometrium, whereas in the adenomyotic foci this expression was negative in the majority of the cases. Oral contraceptives containing gestodene, on the other hand, were effective in suppressing aromatase expression in both eutopic and ectopic endometrium. COX-2 expression was detected by immunohistochemistry in the glandular epithelium of both eutopic endometrium and adenomyotic foci and there were no significant changes in its intensity throughout the menstrual cycle. CONCLUSION: Aromatase expression in the eutopic endometrium and adenomyotic foci is suppressed by oral contraceptives containing gestodene. Increased aromatase activity may be responsible for the persistent COX-2 expression during the luteal phase. 相似文献