全文获取类型
收费全文 | 2911篇 |
免费 | 129篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 137篇 |
妇产科学 | 64篇 |
基础医学 | 333篇 |
口腔科学 | 61篇 |
临床医学 | 215篇 |
内科学 | 568篇 |
皮肤病学 | 53篇 |
神经病学 | 192篇 |
特种医学 | 156篇 |
外科学 | 361篇 |
综合类 | 83篇 |
预防医学 | 211篇 |
眼科学 | 116篇 |
药学 | 292篇 |
中国医学 | 16篇 |
肿瘤学 | 156篇 |
出版年
2023年 | 19篇 |
2022年 | 44篇 |
2021年 | 110篇 |
2020年 | 69篇 |
2019年 | 73篇 |
2018年 | 96篇 |
2017年 | 49篇 |
2016年 | 66篇 |
2015年 | 88篇 |
2014年 | 116篇 |
2013年 | 146篇 |
2012年 | 220篇 |
2011年 | 231篇 |
2010年 | 123篇 |
2009年 | 107篇 |
2008年 | 170篇 |
2007年 | 174篇 |
2006年 | 138篇 |
2005年 | 138篇 |
2004年 | 125篇 |
2003年 | 102篇 |
2002年 | 83篇 |
2001年 | 72篇 |
2000年 | 66篇 |
1999年 | 54篇 |
1998年 | 23篇 |
1997年 | 13篇 |
1996年 | 15篇 |
1995年 | 11篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1992年 | 26篇 |
1991年 | 30篇 |
1990年 | 22篇 |
1989年 | 20篇 |
1988年 | 25篇 |
1987年 | 21篇 |
1986年 | 13篇 |
1985年 | 15篇 |
1984年 | 12篇 |
1983年 | 11篇 |
1979年 | 16篇 |
1977年 | 9篇 |
1976年 | 8篇 |
1975年 | 10篇 |
1974年 | 8篇 |
1973年 | 5篇 |
1972年 | 6篇 |
1971年 | 5篇 |
1968年 | 5篇 |
排序方式: 共有3047条查询结果,搜索用时 15 毫秒
1.
Conall T. Morgan Brigitte Mueller Varsha Thakur Vitor Guerra Callaghan Jull Luc Mertens Mark Friedberg Fraser Golding Mike Seed Steven E.S. Miner Edgar T. Jaeggi Cedric Manlhiot Lynne E. Nield 《The Canadian journal of cardiology》2019,35(4):453-461
Background
The purpose of the study was to evaluate the association between fetal echocardiographic measurements and the need for intervention (primary coarctation repair, staged coarctation repair, or catheter intervention) in prenatally diagnosed coarctation of the aorta.Methods
A single-centre retrospective cohort study (2005-2015) of 107 fetuses diagnosed with suspected coarctation of the aorta in the setting of an apex-forming left ventricle and antegrade flow across the mitral and aortic valves.Results
Median gestational age at diagnosis was 32 weeks (interquartile range, 23-35 weeks). Fifty-six (52%) did not require any neonatal intervention, 51 patients (48%) underwent a biventricular repair. In univariable analysis, an increase in ascending aorta (AAo) peak Doppler flow velocity (odds ratio [OR], 1.40 [95% confidence interval [CI], 1.05-1.91] per 20 cm/s; P = 0.03) was associated with intervention. No intervention was associated with larger isthmus size (OR, 0.23; P < 0.001), transverse arch diameter (OR, 0.23; P < 0.001), and aortic (OR, 0.72; P = 0.02), mitral (OR, 0.58; P = 0.001), and AAo (OR, 0.53; P < 0.001) z-scores. In multivariable analysis, higher peak AAo Doppler (OR, 2.51 [95% CI, 1.54-4.58] per 20 cm/s; P = 0.001) and younger gestational age at diagnosis (OR, 0.81 [95% CI, 0.70-0.93] per week; P = 0.005) were associated with intervention, whereas a higher AAo z-score (OR, 0.65 [95% CI, 0.43-0.94] per z; P = 0.029) and transverse arch dimension (OR, 0.44 [95% CI, 0.18-0.97]; P = 0.05) decreased the risk of intervention.Conclusions
In prenatally suspected coarctation, the variables associated with intervention comprised smaller AAo and transverse arch size, earlier gestational age at diagnosis, and the additional finding of a higher peak AAo Doppler. 相似文献2.
After the interaction of estrogen with the ligand binding domain (LBD) of mouse estrogen receptor‐α (mERα) and hormone‐responsive elements of target genes, many nuclear proteins are recruited to regulate the expression of specific genes. Because it is not known which brain proteins interact with LBD or whether these proteins vary with age and sex, we used pull‐down assay and far Western blotting to detect five nuclear proteins of 160, 140, 87, 60, and 46 kD in the mouse brain. These interacting proteins were identified as PELP1, RIP140, PGC1α, BAF60, and ADA3, respectively. The level of PELP1, RIP140, PGC1α, and BAF60 decreased drastically in old compared with adult male mice, whereas the ADA3 level showed no significant change. PELP1, PGC1α, and BAF60 levels were lower in old male compared with female mice. Thus we report the identification and interaction of five nuclear proteins with mERα‐LBD, indicating their role in estrogen signaling and brain functions during aging. © 2009 Wiley‐Liss, Inc. 相似文献
3.
Akshay Pratap Devendra Kumar Gupta Chandra Shekhar Agrawal Rakesh Kumar Pandit Shailesh Adhikary Anand Kumar Awadhesh Tiwari Satyendra Narayan Singh 《International journal of urology》2007,14(3):198-202
OBJECTIVES: We analyzed the methods and outcomes of urethroplasty in men with complex urethral disruptions. METHODS: The medical records of 40 men with complex urethral disruptions were analyzed. Surgical methods were individualized according to stricture location, severity and length of the stricture, bladder neck characteristics and presence of complicating factors. Patients were divided into four groups based on the above characteristics. RESULTS: End-to-end urethroplasty performed in six patients with short bulbar strictures (<3 cm) was successful in all. Elaborated perineal repair was performed in 10 patients with intermediate (3-6 cm) strictures with or without complicating factors. Elaborated perineal repair with urethral substitution was performed in nine patients with long segment stricture (>6 cm). Abdominal transpubic repair was successfully applied to patients with rectourethral fistula or lacerated bladder neck. Success rate of anastomotic urethroplasty was 95% while over all success rate was 85%. CONCLUSION: Guidelines for urethral reconstruction of complex urethral disruptions are predicated on stricture length, location, bladder neck characteristics and associated complicating factors. End-to-end urethroplasty with stricture excision is highly reliable for short strictures for which previous operative repair have failed. Elaborated perineal repair is extremely versatile for intermediate and longer strictures with associated complicating factors. Abdominal transpubic urethroplasty is effective for patients with rectourethral fistula or lacerated bladder neck. 相似文献
4.
Modulation of cytokine production from an EpiOcular corneal cell culture model in response to Staphylococcus aureus superantigen 总被引:3,自引:0,他引:3
A Thakur PhD A Clegg MSc A Chauhan MSc MDP Willcox PhD 《Clinical & experimental ophthalmology》1997,25(4):43-45
The present study investigated the hypothesis that Staphylococcus aureus enterotoxin B (SEE) produces epithelial cell death and releases inflammatory cytokines that produce stromal infiltration during contact lens induced peripheral ulceration. Epithelial cells were incubated with different doses of SEB for various time periods. Culture supernatants were assayed for cytokines IL- lo, IL-6 and chemotactic agents IL-8 and LTB,. SEE induced the production of IL- I p and IL-8. Epithelial cells exposed for longer periods (48 h) with low concentrations of SEB produced significantly higher levels (N0.02) of IL-Ip and IL-8 (P<0.05) compared t o a 24 h exposure. SEB did not induce the production o f IL-6 and 相似文献
5.
6.
7.
8.
J Rajeev Shoba Srinath Y C J Reddy M G Shashikiran Satish Chandra Girimaji Shekhar P Seshadri D K Subbakrishna 《Revue canadienne de psychiatrie》2003,48(1):52-55
OBJECTIVE: Recent studies of patients with juvenile bipolar disorder report low rates of recovery and high rates of chronicity. However, we lack data on the short-term outcome. This study examines the pattern of recovery from the index episode in an aggressively treated juvenile sample. METHOD: We assessed 25 subjects (< 16 years) with a diagnosis of mania, using the Diagnostic Interview for Children and Adolescents-Revised) (DICA-R), Young Mania Rating Scale (YMRS), and Children's Global Assessment Scale (CGAS) at intake and at 3 and 6 months. We studied the time taken to recover from the index episode, the level of functioning, and the factors predicting them. RESULTS: After 6 months, 24 (96%) subjects had recovered from the index manic episode. The median time to recovery was 27 days. Total episode length was significantly longer among those with previous affective episodes. CONCLUSIONS: The findings suggest that juvenile-onset mania has high rates of recovery and low rates of chronicity. These differences from the existing literature need further exploration. 相似文献
9.
10.
A new patellar angle is described in lateral radiographs of the knee joint. One line is drawn along the articular surface of the patella and another from the end of the inferior articular cartilage to the patellar apex. The angle formed by these two lines averaged 33° in 68 knees joints afflicted with Osgood-Schlatter disease and 47° in 71 age-matched controls and 198 adult controls. The small angle in Osgood-Schlatter disease is proposed to be an important factor in the pathogenesis of the traction apophysitis. 相似文献