全文获取类型
收费全文 | 543388篇 |
免费 | 35636篇 |
国内免费 | 762篇 |
专业分类
耳鼻咽喉 | 7178篇 |
儿科学 | 17245篇 |
妇产科学 | 13849篇 |
基础医学 | 89024篇 |
口腔科学 | 15410篇 |
临床医学 | 46337篇 |
内科学 | 100847篇 |
皮肤病学 | 12975篇 |
神经病学 | 38245篇 |
特种医学 | 19583篇 |
外国民族医学 | 63篇 |
外科学 | 82338篇 |
综合类 | 8624篇 |
一般理论 | 119篇 |
预防医学 | 39878篇 |
眼科学 | 12765篇 |
药学 | 42748篇 |
中国医学 | 1049篇 |
肿瘤学 | 31509篇 |
出版年
2018年 | 5438篇 |
2016年 | 4570篇 |
2015年 | 5049篇 |
2014年 | 6758篇 |
2013年 | 10425篇 |
2012年 | 14186篇 |
2011年 | 15722篇 |
2010年 | 9141篇 |
2009年 | 8535篇 |
2008年 | 14975篇 |
2007年 | 15977篇 |
2006年 | 16248篇 |
2005年 | 15760篇 |
2004年 | 15346篇 |
2003年 | 14692篇 |
2002年 | 14511篇 |
2001年 | 25224篇 |
2000年 | 26248篇 |
1999年 | 21616篇 |
1998年 | 5794篇 |
1997年 | 5019篇 |
1996年 | 5329篇 |
1995年 | 4891篇 |
1994年 | 4553篇 |
1993年 | 4364篇 |
1992年 | 16460篇 |
1991年 | 16951篇 |
1990年 | 17073篇 |
1989年 | 16417篇 |
1988年 | 15202篇 |
1987年 | 14961篇 |
1986年 | 14144篇 |
1985年 | 13506篇 |
1984年 | 9991篇 |
1983年 | 8539篇 |
1982年 | 4695篇 |
1979年 | 9699篇 |
1978年 | 7039篇 |
1977年 | 5912篇 |
1976年 | 5716篇 |
1975年 | 6531篇 |
1974年 | 7830篇 |
1973年 | 7261篇 |
1972年 | 7116篇 |
1971年 | 6822篇 |
1970年 | 6287篇 |
1969年 | 6001篇 |
1968年 | 5670篇 |
1967年 | 5094篇 |
1966年 | 4530篇 |
排序方式: 共有10000条查询结果,搜索用时 359 毫秒
1.
2.
Keiko Goto Yutaka Fujiwara Takeshi Isobe Naoko Chayahara Naomi Kiyota Toru Mukohara Yukari Tsubata Takamasa Hotta Kenji Tamura Noboru Yamamoto Hironobu Minami 《Cancer science》2019,110(6):1987-1994
Although dose reduction of S‐1 is recommended for patients with impaired renal function, dose modification for such patients has not been prospectively evaluated. The aim of the present study was to investigate the pharmacokinetic parameters of 5‐fluorouracil, 5‐chloro‐2,4 dihydroxypyridine and oteracil potassium, and to review the recommended dose modification of S‐1 in patients with renal impairment. We classified patients receiving S‐1 into 4 groups according to their renal function, as measured using the Japanese estimated glomerular filtration rate (eGFR) equation. The daily S‐1 dose was adjusted based on the patient's eGFR and body surface area. Blood samples were collected for pharmacokinetic analysis. A total of 33 patients were enrolled and classified into 4 groups as follows: 10 patients in cohort 1 (eGFR ≥ 80 mL/min/1.73 m2), 10 patients in cohort 2 (eGFR = 50‐79 mL/min/1.73 m2), 10 patients in cohort 3 (eGFR = 30‐49 mL/min/1.73 m2), and 3 patients in cohort 4 (eGFR < 30 mL/min/1.73 m2). Those in cohorts 3 and 4 treated with an adjusted dose of S‐1 showed a similar area under the curve for 5‐fluorouracil (941.9 ± 275.6 and 1043.5 ± 224.8 ng/mL, respectively) compared with cohort 2 (1034.9 ± 414.3 ng/mL). Notably, while there was a statistically significant difference between cohort 1 (689.6 ± 208.8 ng/mL) and 2 (P = 0.0474) treated with an equal dose of S‐1, there was no significant difference observed in the toxicity profiles of the cohorts. In conclusion, dose adjustment of S‐1 in patients with impaired renal function using eGFR is appropriate and safe. 相似文献
3.
4.
5.
6.
7.
Alexander E. J. Trevatt David R. Thomson Robert Miller Matthew Colquhoun Akinyemi I. Idowu Shakeel Rahman 《Journal of plastic surgery and hand surgery》2019,53(2):97-104
Academic output is just one aspect of a successful career as a plastic surgeon. However, for those with a strong interest in academia, the academic output of a department will likely be a key factor when deciding how to rank jobs. The aim of this study was to quantify and rank the academic output of plastic surgery units across the UK and Ireland. The Institute for Scientific Information (ISI) Web of Science Bibliometric analysis tool was used to collate cumulative (1950–2016), 10 year (2006–2016) and 3 years (2013–2015) research output data for plastic surgery units in the UK and Ireland. Sixty-six plastic surgery units were identified. Departments were ranked for each time period according to the number of papers produced, number of citations (Nc) and h-index (a measure of the impact of scientific output). The top 3 departments for number of papers in the last 10 years were The Royal Free Hospital, London (226) Broomfield Hospital, Chelmsford (218), and Morriston Hospital and Swansea (188). The top 3 for h-number were The Royal Free Hospital (21) Wythenshawe Hospital, Manchester (18) and Morriston Hospital (17). Academic output varies across plastic surgery units in the UK and Ireland. A number of departments have consistently maintained high academic outputs across the years and will be of interest to surgeons hoping to pursue a career in academia. 相似文献
8.
9.
Novozhilov A. V. Mindukshev I. V. Korf E. A. Krivchenko A. I. Goncharov N. V. 《Bulletin of experimental biology and medicine》2020,168(4):444-448
Bulletin of Experimental Biology and Medicine - Ammonium, an end-product of catabolism, in low doses can promote adaptation of metabolic pathways in erythrocytes under conditions of extreme... 相似文献
10.
Christopher Teng JiaDe Yu Jesse Taylor Adam I. Rubin James R. Treat 《Pediatric dermatology》2019,36(5):697-701
Erosive pustular dermatosis of the scalp (EPDS) is an uncommon chronic inflammatory response to scalp trauma that usually resolves with cicatricial alopecia. It most commonly affects elderly patients with a history of actinic damage. Herein, we describe a 16‐year‐old girl with acrofacial dysostosis type 1 presenting after surgery with crusting purulent scalp lesions, whose clinical presentation and histopathologic findings were consistent with EPDS. A review of the literature on EPDS in children is also detailed. 相似文献