全文获取类型
收费全文 | 1404篇 |
免费 | 56篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 50篇 |
妇产科学 | 32篇 |
基础医学 | 163篇 |
口腔科学 | 32篇 |
临床医学 | 116篇 |
内科学 | 299篇 |
皮肤病学 | 31篇 |
神经病学 | 57篇 |
特种医学 | 87篇 |
外科学 | 233篇 |
综合类 | 23篇 |
预防医学 | 48篇 |
眼科学 | 36篇 |
药学 | 115篇 |
中国医学 | 6篇 |
肿瘤学 | 124篇 |
出版年
2023年 | 9篇 |
2022年 | 29篇 |
2021年 | 59篇 |
2020年 | 31篇 |
2019年 | 46篇 |
2018年 | 56篇 |
2017年 | 44篇 |
2016年 | 44篇 |
2015年 | 37篇 |
2014年 | 55篇 |
2013年 | 78篇 |
2012年 | 125篇 |
2011年 | 113篇 |
2010年 | 66篇 |
2009年 | 56篇 |
2008年 | 92篇 |
2007年 | 99篇 |
2006年 | 82篇 |
2005年 | 81篇 |
2004年 | 49篇 |
2003年 | 64篇 |
2002年 | 39篇 |
2001年 | 23篇 |
2000年 | 20篇 |
1999年 | 11篇 |
1998年 | 9篇 |
1997年 | 9篇 |
1996年 | 6篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 5篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1970年 | 2篇 |
1925年 | 1篇 |
排序方式: 共有1473条查询结果,搜索用时 15 毫秒
1.
2.
The frozen elephant trunk technique for the treatment of extensive thoracic aortic aneurysms: operative results and follow-up. 总被引:1,自引:0,他引:1
Matthias Karck Ajay Chavan Nawid Khaladj Holger Friedrich Christian Hagl Axel Haverich 《European journal of cardio-thoracic surgery》2005,28(2):286-90; discussion 290
OBJECTIVE: The 'frozen' elephant trunk technique allows for single-stage repair of combined aortic arch and descending aortic aneurysms using a 'hybridprosthesis' with a stented and a non-stented end. This report summarizes the operative- and follow-up data (mean follow-up 14 months) with this new treatment. METHODS: Between 09/01 and 4/04, 22 patients (62+/-9 years; 9 female) with different aortic pathologies (15 aortic dissections, 7 aneurysms) were operated on after approval from the local institutional review board. The stented end of the hybridprosthesis was deployed in the descending aorta through the opened aortic arch during hypothermic circulatory arrest and selective antegrade cerebral perfusion. RESULTS: All patients survived the procedure but one patient died of acute hemorrhage due to rupture of the false lumen in the descending aorta on the second postoperative day. Two patients required reexploration of the chest for bleeding complications. In 2 of 4 patients who developed neurological dysfunction, symptoms resolved completely. In one of them, the descending aorta was perforated intraoperatively due to misplacement of the stented end of the hybridprosthesis. In all follow-up CT-scans thrombus formation in the descending aortic aneurysm excluded by the stented end of the hybridprosthesis has been observed. CONCLUSIONS: This procedure is performed through median sternotomy and combines the concepts of the elephant trunk operation and endovascular stenting of descending aortic aneurysms. Favourable intraoperative and postoperative results during follow-up with regard to thrombus formation around the stented descending aortic segment encourage us to evaluate all patients with thoracic aneurysms extending to proximal and distal of the left subclavian artery for this treatment. 相似文献
3.
Mihir Prakash Pandia Parmod Kumar Bithal Hemant Bhagat Munish Sharma 《Journal of clinical neuroscience》2007,14(11):1139-1141
We report respiratory obstruction following surgery in the sitting position with tracheal intubation and placement of a transesophageal echocardiography probe. Obstruction was due to pharyngeal oedema, which resolved with 24 hours. The mechanisms of this complication are discussed. 相似文献
4.
5.
Schallreuter KU Chavan B Rokos H Hibberts N Panske A Wood JM 《Molecular genetics and metabolism》2005,86(Z1):S27-S33
The human epidermis has the full machinery for autocrine L-phenylalanine turnover to L-tyrosine in keratinocytes and melanocytes. Phenylalanine hydroxylase (PAH) activities increase linearly with inherited skin colour (skin phototype I-VI, Fitzpatrick classification) yielding eightfold more activities in black skin compared to white skin. Moreover, UVB irradiation (1 MED) significantly increases epidermal PAH activities 24 h after exposure. Importantly, L-phenylalanine uptake and turnover in the pigment forming melanocytes is vital for initiation of melanogenesis. In this context it was shown that the uptake of this amino acid is regulated by calcium. The depigmentation disorder vitiligo provides a unique model to follow impaired L-phenylalanine turnover in the skin as well as in serum because affected individuals hold an impaired epidermal 6BH4 de novo synthesis/recycling and regulation including low epidermal PAH activities. After overnight fasting and oral loading with L-phenylalanine (100 mg/kg body weight), 29.6% of 970 patients tested (n=287/970) yielded serum phenylalanine/tyrosine ratios >or=4 and 35.3% (n=342/970) had mild to moderate hyperphenylalaninaemia (HPA), while 9.3% (n=90/970) had both serum L-phenylalanine levels >or=2.0 mg/dl and phe/tyr ratios >or=4.0. Isolated HPA was found in 26% (n=252/970), whereas 20.3% had only increased ratios (n=197/970). None of the patients had phenylketonuria and the family history for this metabolic disease was negative. The IQ followed normal Gaussian distribution. In vitro L-phenylalanine uptake/turnover studies on primary epidermal melanocytes originating from these patients demonstrated a significantly decreased calcium dependent L-phenylalanine uptake and turnover compared to healthy control cells. Based on our observation, we would like to propose that phenylalanine uptake/turnover is under tight control by calcium which in turn could offer an additional novel mechanism in the aetiology of HPA. 相似文献
6.
7.
8.
Vladimir Turzhitsky Yang Liu Nahla Hasabou Michael Goldberg Hemant K. Roy Vadim Backman Randall Brand 《Disease markers》2008,25(6):313-321
Pancreatic cancer screening has been hampered by the high rate of complications associated with interrogating the pancreas. The closest non-invasively accessible mucosa available for pancreatic cancer screening is the periampullary duodenal tissue. Our earlier report has shown the potential of using optical markers to interrogate this tissue for the presence of pancreatic cancer. In this study, we report a larger data set of low-coherence enhanced backscattering (LEBS) and elastic light scattering fingerprinting (ELF) optical markers from the periampullary duodenal mucosa. Optical measurements from biopsy samples were acquired from a total of 203 patients with varying clinical classification including healthy controls, a family history of pancreatic cancer, pancreatitis, mucinous cystic precursor lesions, pancreatic cancer, and other pancreatic malignancies. Evaluation of the performance of an independent testing set for discriminating healthy control patients from pancreatic cancer patients showed a 95% sensitivity, 71% specificity, and 85% area under the receiver operator characteristic (AUROC) curve. Importantly, this performance was uncompromised for detecting potentially curable stages of the disease. Additionally, optical markers in higher risk populations such as family history and pancreatitis had values between those of healthy control and pancreatic cancer patients, thus allowing for future investigations of screening from these high risk groups. 相似文献
9.
Hemant Parmar Deepak Patkar Jeshil Shah Tufail Patankar 《Journal of Medical Imaging and Radiation Oncology》2003,47(4):438-442
Hemimegalencephaly is a rare cerebral malformation characterized by asymmetry of the hemispheres and cortical dysplasias. We report clinical and imaging findings in a child with hemimegalencephaly involving the right cerebral hemisphere with associated manifestations of tuberous sclerosis complex. Gross abnormal myelination pattern and gyral abnormalities were seen in the enlarged hemisphere. Subsequent scans showed atrophy of the frontoparietal region in the enlarged hemisphere and normal growth of the opposite hemisphere exceeding the size of the abnormal hemisphere in the frontoparietal region. A few white‐matter lesions that were seen in the normal hemisphere on neonatal scan were difficult to appreciate on subsequent MR studies. The white‐matter lesions were better seen in the neonatal period, whereas cortical tubers were better detected at a later age. 相似文献
10.