全文获取类型
收费全文 | 3136篇 |
免费 | 201篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 84篇 |
儿科学 | 161篇 |
妇产科学 | 67篇 |
基础医学 | 517篇 |
口腔科学 | 64篇 |
临床医学 | 170篇 |
内科学 | 656篇 |
皮肤病学 | 61篇 |
神经病学 | 249篇 |
特种医学 | 67篇 |
外科学 | 251篇 |
综合类 | 12篇 |
预防医学 | 318篇 |
眼科学 | 102篇 |
药学 | 402篇 |
中国医学 | 18篇 |
肿瘤学 | 151篇 |
出版年
2023年 | 29篇 |
2022年 | 36篇 |
2021年 | 85篇 |
2020年 | 68篇 |
2019年 | 84篇 |
2018年 | 158篇 |
2017年 | 139篇 |
2016年 | 131篇 |
2015年 | 133篇 |
2014年 | 212篇 |
2013年 | 258篇 |
2012年 | 335篇 |
2011年 | 370篇 |
2010年 | 189篇 |
2009年 | 94篇 |
2008年 | 123篇 |
2007年 | 105篇 |
2006年 | 124篇 |
2005年 | 94篇 |
2004年 | 79篇 |
2003年 | 73篇 |
2002年 | 59篇 |
2001年 | 35篇 |
2000年 | 34篇 |
1999年 | 37篇 |
1998年 | 13篇 |
1997年 | 14篇 |
1996年 | 9篇 |
1994年 | 9篇 |
1992年 | 9篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 9篇 |
1986年 | 7篇 |
1985年 | 10篇 |
1984年 | 14篇 |
1983年 | 11篇 |
1982年 | 5篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1979年 | 7篇 |
1978年 | 11篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1975年 | 8篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1969年 | 5篇 |
排序方式: 共有3350条查询结果,搜索用时 0 毫秒
1.
2.
Johanna Albert Leif Kindlund Barbro Nilvér Waldemar Gożdzik 《Central European Journal of Medicine》2006,1(2):162-171
Abstract: Background: The laryngeal mask airway (LMA) can be used in general anaesthesia without neuromuscular block. The
laryngeal tube (LT) is a new airway device with similar airway features as LMA. LT is provided with a distal cuff to prevent
regurgitation. In this study we compared the LMA and LT concerning patient and user aspects.
Methods: Sixty patients with ASA (American Society of Anestesiologists) score 1–2 scheduled for minor surgery were randomized
to be ventilated either through LMA or LT. After insertion, the number of insertion attempts, and “positioning” and “airway-assessment”
was evaluated. The patients reported on “sore throat” after 30 and 60 minutes and the day after anaesthesia.
Results: Gender and mean age were equal in both groups. The first insertion attempt was successful in 25 of 28 patients randomised
to LMA and in 23 of 27 patients randomised to LT. LMA was evaluated to be easier in “positioning” whereas no difference in
“sore throat” was reported.
Conclusion: We found no difference between the LMA and the LT in terms user and patient friendliness and safety. 相似文献
3.
M A Blankenstein J Szymczak J Daroszewski A Milewicz J H Thijssen 《Gynecological endocrinology》1992,6(1):13-17
Breast cancer tissue is able to maintain the tissue estradiol level in spite of the massive decrease in plasma estradiol associated with menopause, whereas fatty tissue from breasts with malignancies more closely reflects the changes in plasma. In the present study estrone and estradiol levels in fatty tissues from different origins were compared to evaluate the capacity of distant fatty tissues to act as estrogen reservoirs. Abdominal fat was obtained from 25 premenopausal and 20 postmenopausal women who underwent surgery for non-oncological reasons. Estrone and estradiol levels in these tissues were compared to those in breast fatty tissue from breast cancer patients. Plasma estrogen levels were not different in the two groups. In both groups, median plasma estradiol levels dropped sharply with menopause (from 363 to 40 pmol/l in breast cancer patients; from 280 to 45 pmol/l in the non-oncological patients; p less than 0.002), whereas a significant decrease in plasma estrone was observed only in the breast cancer patients (from 238 to 140 pmol/l; p less than 0.02). In premenopausal women, median estrone and estradiol levels in breast fatty tissue (1135 and 375 fmol/g, respectively) and abdominal tissue (1390 and 470 fmol/g, respectively) were not different. In postmenopausal women, however, significantly higher estrone levels (663 vs. 508 fmol/g; p less than 0.01) and estradiol levels (245 vs. 187 fmol/g; p less than 0.02) were found in abdominal fatty tissue. In view of the absolute estrogen levels in breast and abdominal fatty tissue and in plasma, we conclude, however, that it is unlikely that remote fat contributes substantially to the maintenance of estrogen levels in breast cancer tissue. 相似文献
4.
J. Sanchez Burson J. Graña Gil M. Rosales Rodriguez A. Atanes Sandoval C. Alonso Blanco F. Galdo Fernandez 《Clinical rheumatology》1992,11(2):261-264
Summary We have studied the characteristics of arthritis present in 32 patients with Behçet's disease (BD), and how this arthritis is related to the HLA markers class I. 84% of the patients presented arthritis, the most common being monoarthritis as the initial presentation, and oligoarthritis in subsequent episodes. In 63% of the cases, the development was in episodes of acute/subacute arthritis. We found statistically significant association between antigens B-5 and B-51, and the group with BD, with a relative risk of 3.89 and 4.71 respectively. The attempt to relate markers B-5, B-51 and B-27 to the presence of arthritis as well as to its manifestation and further development was not conclusive. 相似文献
5.
Anna Letícia Soares Marinez de Oliveira Sousa Luci Maria Dusse Ana Paula Salles Moura Fernandes Marcelo Carvalho Lasmar Bethania Alves Novelli Geralda de Fátima Guerra Lages Maria das Gra?as Carvalho 《Blood coagulation & fibrinolysis》2007,18(5):395-399
This study aimed to investigate whether endothelial cells are damaged and to evaluate fibrinolytic system function in patients with type 2 diabetes. For this proposal, plasma levels of von Willebrand factor (an endothelial marker of injury), homocysteine (an inductor of endothelial injury), D-dimer (a marker of coagulation cascade activation) and plasminogen activator inhibitor-1 (a fibrinolysis marker) were measured in individuals with both type 2 diabetes and high blood pressure, with type 2 diabetes, with high blood pressure and in healthy control individuals. No significant differences among groups were observed for von Willebrand factor and homocysteine plasma levels. The type 2 diabetes and high blood pressure group presented a significant difference to the other groups for D-dimer and also presented high values for plasminogen activator inhibitor-1. The high blood pressure group and type 2 diabetes group presented separately higher values of plasminogen activator inhibitor-1 compared with the control group. High levels of D-dimer and plasminogen activator inhibitor-1 in patients with type 2 diabetes and high blood pressure with normoalbuminuria therefore indicate a state of hypercoagulability and hypofibrinolysis, despite no evident microvascular injury supported by normal levels of von Willebrand factor and homocysteine. 相似文献
6.
Priv.-Doz. Dr. med. Dr. jur. R. Dettmeyer H. Graß C. Diefenbach B. Madea 《Rechtsmedizin》2004,14(2):117-122
Report of a case with lethal bleeding into the cervical soft tissue after inadvertent puncture of the carotid artery. After sudden and unexpected cardiac arrest resuscitation was started immediately but intubation failed. Stenosis of the trachea due to hematoma following the puncture was discussed as cause of death as well as thrombembolism and an early septic process. Autopsy revealed an extensive retropharyngeal hematoma but no stenosis of the upper airways. Histological investigations showed extensive bleeding surrounding the sinus caroticum with subcapsular hemorrhages. The sudden onset of the cardiac arrest could have been initiated by a hemorrhage-induced irritation of the sinus caroticum. In the cases reported a lethal irritation of the carotid sinus following external violence has been surmised and there exists only one case report with comparable histological findings from inside and around the glomus caroticum. 相似文献
7.
8.
9.
Anna Szymańska Elżbieta Korobowicz Wiesław Gołąbek 《European archives of oto-rhino-laryngology》2006,263(7):657-660
Nasopharyngeal angiofibromas occur predominantly in males in their puberty and adolescence; the incidence in other age groups and in women is exceptional. This report describes a case of a 57-year-old woman with nasopharyngeal angiofibroma presenting typical radiological findings in computed tomography, MR imaging and angiography. The tumour was successfully removed and histopathological examination confirmed the diagnosis. In 6 years follow-up the patient is free of symptoms. 相似文献
10.
Thomazi AP Godinho GF Rodrigues JM Schwalm FD Frizzo ME Moriguchi E Souza DO Wofchuk ST 《Mechanisms of ageing and development》2004,125(7):475-481
The excitotoxicity of the neurotransmitter glutamate has been shown to be connected with many acute and chronic diseases of the CNS. High affinity sodium-dependent glutamate transporters play a key role in maintaining adequate levels of extracellular glutamate. In the present study, we used slices of striatum, hippocampus and cortex from rat brain to describe the in vitro profile of glutamate uptake during development and ageing, and its sensitivity to guanosine. In all structures, glutamate uptake was higher in immature animals. There was a maximum decrease in glutamate uptake in striatum and hippocampus in 15-month-old rats, which later increased, while in cortex there was a significant decrease in rats aged 60 days old. The effect of guanosine seems to be age and structure dependent since the increase in basal glutamate uptake was only seen in slices of cortex from 10-day-old animals. 相似文献