全文获取类型
收费全文 | 2241篇 |
免费 | 94篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 99篇 |
妇产科学 | 41篇 |
基础医学 | 428篇 |
口腔科学 | 39篇 |
临床医学 | 191篇 |
内科学 | 351篇 |
皮肤病学 | 107篇 |
神经病学 | 232篇 |
特种医学 | 62篇 |
外科学 | 172篇 |
综合类 | 6篇 |
预防医学 | 173篇 |
眼科学 | 40篇 |
药学 | 231篇 |
中国医学 | 7篇 |
肿瘤学 | 155篇 |
出版年
2023年 | 18篇 |
2022年 | 31篇 |
2021年 | 57篇 |
2020年 | 24篇 |
2019年 | 57篇 |
2018年 | 40篇 |
2017年 | 32篇 |
2016年 | 53篇 |
2015年 | 52篇 |
2014年 | 78篇 |
2013年 | 101篇 |
2012年 | 163篇 |
2011年 | 149篇 |
2010年 | 91篇 |
2009年 | 56篇 |
2008年 | 145篇 |
2007年 | 144篇 |
2006年 | 163篇 |
2005年 | 115篇 |
2004年 | 117篇 |
2003年 | 105篇 |
2002年 | 105篇 |
2001年 | 22篇 |
2000年 | 17篇 |
1999年 | 33篇 |
1998年 | 29篇 |
1997年 | 30篇 |
1996年 | 18篇 |
1995年 | 19篇 |
1994年 | 15篇 |
1993年 | 15篇 |
1992年 | 9篇 |
1991年 | 10篇 |
1990年 | 13篇 |
1988年 | 12篇 |
1987年 | 8篇 |
1986年 | 9篇 |
1985年 | 7篇 |
1984年 | 14篇 |
1982年 | 12篇 |
1981年 | 10篇 |
1980年 | 9篇 |
1978年 | 12篇 |
1977年 | 5篇 |
1976年 | 9篇 |
1974年 | 8篇 |
1971年 | 5篇 |
1967年 | 9篇 |
1959年 | 5篇 |
1958年 | 6篇 |
排序方式: 共有2340条查询结果,搜索用时 15 毫秒
1.
2.
Gisela Gamboa Philip M. Carpenter M.D. Yale D. Podnos Guillermo Dorion M.D. Leila Iravani Denis Bolton James T. Mascarello Ph.D. Alberto Manetta M.D. 《Gynecologic oncology》1995,58(3)
We introduce a new epithelial ovarian carcinoma cell line (UCI 107) from a patient with papillary adenocarcinoma of the ovary who had not been previously treated. The growth characteristics, chemosensitivity, tumorgenicity, cytogenetics, antigen expression, and receptor status were examined. A standardized photometric assay was implemented to determine the response to single drug agents including doxorubicin (ADR), cisplatin (CDDP), and Taxol. Tumorgenicity was determined utilizing female athymic mice implanted either subcutaneously (sc) or intraperitoneally (ip) with 1 × 107 UCI 107 cells. UCI 107 cells grow rapidly in culture with lag phase of approximately 48 hr, population doubling time of 24-36 hr, and saturation density of 4.8 × 105 cells/cm2. The 50% inhibitory concentration values for the chemotherapeutic agents were 0.170, 0.029, and 0.330 μM for ADR, Taxol, and CDDP, respectively. Nude mice produced ip tumors within 15 days, resulting in death from carcinomatosis 40-45 days postimplantation. Subcutaneous tumor nodules (100 mm3 were observed in nude mice 12-13 days post-tumor implantation reaching a maximum tumor volume of approximately 10,000 mm3 by Day 30. The cytogenetic composite karyotype is as follows: 46, X, der (X) t (X;7) (p11;q22), inv dup (1) (q12;q32), t (6;6;11;22) (p21.3;q16;q23.3;q13.3), del (13) (q14.1). The cell line expresses progesterone receptor, increased levels of p53 protein, and cytokeratins. It does not appear to express Her-2/neu protein, estrogen receptor, nor the CA 125 tumor marker. In conclusion, UCI 107 displays unique cellular properties which make it an attractive model for the study of ovarian cancer. 相似文献
3.
4.
Gisela Enders 《International Journal of Clinical & Laboratory Research》1988,18(1):109-116
Le infezioni microbiche possono mettere a rischio la gravidanza e/o la salute del bambino. Esse possono provocare aumento delia morbilitÀ F. dar luogo, a seconda del momento della gestazione in cui si verificano, ad infezione del prodotto del concepimento, ad aborto, a nascita di un nato morto, a malformazioni, ad alterazioni dello sviluppo, a malattie neonatali e ad infezioni croniche dal decorso variabile. 相似文献
5.
Arend Bökenkamp Bettina Bohnhorst Christian Beier Norbert Albers Gisela Offner Johannes Brodehl 《Pediatric nephrology (Berlin, Germany)》1994,8(2):181-185
Gingival hyperplasia is a common side-effect of immunosuppression with cyclosporine A. Nifedipine is often used to control hypertension in kidney graft recipients. Analysis of gingival status in 106 children transplanted at our centre, and treated either with azathioprine, cyclosporine A or both, revealed significantly higher degrees of gingival overgrowth in those children receiving a combination of cyclosporine A and nifedipine compared with those children treated with cyclosporine A or nifedipine alone. Seven children undergoing gingivectomy at our centre over the past few years had received this combination. After a change in the antihypertensive regimen, avoiding long-term nifedipine medication, and improved dental care with chlorhexidine gel, we noted a reduction in the degree of gingival hyperplasia. In the majority of patients, nifedipine could be replaced by a single drug, usually hydralazine. We therefore recommend avoiding calcium channel blockers in the long-term management of hypertension in patients receiving cyclosporine. 相似文献
6.
Thorsten Gerstner Deike Buesing Elke Longin Claudia Bendl Dieter Wenzel Brigitte Scheid Gisela Goetze Alfons Macke Gerhard Lippert Wolfgang Klostermann Geert Mayer Regine Augspach-Hofmann Sabine Fitzek Carl-Albrecht Haensch Markus Reuland Stephan A Koenig 《Seizure》2006,15(6):443-448
Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well-tolerated. Rare serious complications may occur in some patients, including haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity and VPA-induced encephalopathy. The typical signs of VPA-induced encephalopathy are impaired consciousness, sometimes marked EEG background slowing, increased seizure frequency, with or without hyperammonemia. There is still no proof of causative effect of VPA in patients with encephalopathy, but only of an association with an assumed causal relation. We report 19 patients with VPA-associated encephalopathy in Germany from the years 1994 to 2003, none of whom had been published previously. 相似文献
7.
Pape Lars; Mengel Michael; Offner Gisela; Ehrich Jochen H.H. 《Nephrology, dialysis, transplantation》2004,19(12):3207
Sir, A 4-year-old boy presented with oedema and weight gain of 5kg. There had been no preceding infections, vaccinations ormedication. The family history includes the mothers mesangioproliferativeglomerulonephritis. Laboratory results showed decreased albumin (13 g/l) concentration.Calculated glomerular filtration rate was 125 ml/min/1.73 m2and the 相似文献
8.
Friedrich Krull Arend Bökenkamp Gisela Offner 《Pediatric nephrology (Berlin, Germany)》1992,6(2):192-193
We report the case of a 7-year-old boy who developed severe erythrocytosis 4 months after successful kidney transplantation, with a well-functioning graft. When the haematocrit rose above 60%, phlebotomy had to be performed once to twice a week in order to keep the haematocrit below 50%. A 3-month course of theophylline therapy did not influence the erythrocytosis significantly. There were 5 further patients with erythrocytosis out of 186 children who had undergone kidney transplantation at our centre. 相似文献
9.
10.
Derik Hermann Alexander Sartorius Helga Welzel Sigrid Walter Gisela Skopp Gabriele Ende Karl Mann 《Neuropsychopharmacology》2007,61(11):1281-1289
BACKGROUND: Cannabinoids present neurotoxic and neuroprotective properties in in vitro studies, inconsistent alterations in human neuroimaging studies, neuropsychological deficits, and an increased risk for psychotic episodes. METHODS: Proton magnetic resonance spectroscopy ((1)H-MRS), neuropsychological testing, and hair analysis for cannabinoids was performed in 13 male nontreatment-seeking recreational cannabis users and 13 male control subjects. RESULTS: A significantly diminished N-acetylaspartate/total creatine (NAA/tCr) ratio in the dorsolateral prefrontal cortex (DLPFC) was observed in cannabis users (p = .0003). The NAA/tCr in the putamen/globus pallidum region correlated significantly with cannabidiol (R(2) = .66, p = .004). Results of the Wisconsin Card Sorting test, Trail making Test, and D2 test for attention were influenced by cannabinoids. CONCLUSIONS: Chronic recreational cannabis use is associated with an indication of diminished neuronal and axonal integrity in the DLPFC in this study. As chronic cannabis use is a risk factor for psychosis, these results are interesting because diminished NAA/tCr ratios in the DLPFC and neuropsychological deficits were also reported in schizophrenia. The strong positive correlation of NAA/tCr and cannabidiol in the putamen/globus pallidum is in line with neuroprotective properties of cannabidiol, which were also observed in in vitro model studies of Parkinson's disease. 相似文献