Synthesis of a New Structural Analog of the Natural Thyrotropin-Releasing Hormone

Pharmaceutical Chemistry Journal -     

Synthesis of structural analogs of the 1–4 somatoliberin fragment

Amethod for the synthesis of new structural analogs of the 1–4 somatoliberin peptide sequence is described. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 4, pp. 45–46, April, 2006.     

Orthostatic heart rate responses after prolonged space flights

Orthostatic tachycardia (POTS) can occur after space flights. We determined orthostatic heart rate responses in 18 cosmonauts before and 3–5 days after long-term space missions. Cosmonauts undergoing a cardiovascular training program in space experienced only moderate POTS after their return to earth. Cardiovascular countermeasures may have attenuated POTS. Another possible interpretation is that cardiovascular deconditioning is not sufficient to elicit full blown POTS in the absence of additional genetic or environmental factors.     

Assessment and prediction of health status of the Mars mission crew members]

The scientific concept of health assessment and prediction in a piloted mission to Mars has been built on the principles of pre-nosologic diagnostics, i.e., identification of the norm-pathology borderline states. The article deals with the medical care policy for the mission, and specific techniques and technologies. A three-level system of health assessment and prediction is proposed. Innovative approaches to evaluation of the body control systems during long exposure in microgravity have a footing of ground-based and space experimental investigations. Namely, these include evaluation of the cardiorespiration autonomous regulation and body functional reserve assessment by noninvasive recording of physiological signals in sleeping crewmembers before and after mission.     

Evaluation of physical work capacity of the astronauts on Saliut-6

Electrocardiograms of Salyut-6 prime crew-members recorded during their exercises on a bicycle ergometer and treadmill are presented. ECG were recorded by a portable tape recorder Cardiocassette and transmitted to the Earth via the radiocommunication channel. This procedure helped to better understand cardiovascular adaptation to different workloads, including submaximal, as well as reserve abilities of the body at various flight stages. This can be used advantageously to correct and control the training process as well as to predict the cardiovascular status at the final flight stage.