全文获取类型
收费全文 | 1918篇 |
免费 | 165篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 36篇 |
妇产科学 | 21篇 |
基础医学 | 333篇 |
口腔科学 | 51篇 |
临床医学 | 185篇 |
内科学 | 343篇 |
皮肤病学 | 94篇 |
神经病学 | 312篇 |
特种医学 | 85篇 |
外科学 | 210篇 |
综合类 | 3篇 |
一般理论 | 2篇 |
预防医学 | 137篇 |
眼科学 | 34篇 |
药学 | 95篇 |
中国医学 | 2篇 |
肿瘤学 | 138篇 |
出版年
2023年 | 53篇 |
2022年 | 72篇 |
2021年 | 126篇 |
2020年 | 76篇 |
2019年 | 98篇 |
2018年 | 101篇 |
2017年 | 76篇 |
2016年 | 89篇 |
2015年 | 105篇 |
2014年 | 102篇 |
2013年 | 122篇 |
2012年 | 171篇 |
2011年 | 149篇 |
2010年 | 83篇 |
2009年 | 74篇 |
2008年 | 83篇 |
2007年 | 78篇 |
2006年 | 90篇 |
2005年 | 76篇 |
2004年 | 73篇 |
2003年 | 36篇 |
2002年 | 52篇 |
2001年 | 14篇 |
2000年 | 10篇 |
1999年 | 6篇 |
1998年 | 8篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 6篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1985年 | 6篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1980年 | 2篇 |
1970年 | 4篇 |
1966年 | 1篇 |
1959年 | 3篇 |
1949年 | 1篇 |
1943年 | 1篇 |
1939年 | 1篇 |
1938年 | 3篇 |
1934年 | 2篇 |
1933年 | 1篇 |
1930年 | 2篇 |
1929年 | 2篇 |
1925年 | 1篇 |
1923年 | 1篇 |
排序方式: 共有2096条查询结果,搜索用时 15 毫秒
1.
Hommes Franziska Mohsenpour Amir Kropff Dana Pilgram Lisa Matusall Svenja von Philipsborn Peter Sell Kerstin 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2022,65(1):96-106
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Akteure der öffentlichen Gesundheit (Public Health) tragen wesentlich zu Gesundheitsschutz, -förderung und... 相似文献
2.
Dorota Gabry's Annegret Dörfler Ala Yaromina Franziska Hessel Mechthild Krause Reinhard Oertel Prof. Dr. Michael Baumann 《Strahlentherapie und Onkologie》2008,184(1):48-53
PURPOSE: To evaluate the effect of lovastatin alone or combined with radiation on U87MG and FaDu cells in vitro and U87MG tumors in vivo. MATERIAL AND METHODS: Cell number, p21(WAF1) expression, apoptosis, reproductive cell death, and cell-cycle distribution were investigated after incubation of U87MG and FaDu cells in vitro. The effect of lovastatin (50 mg/kg/day) on tumor growth and on tumor growth delay after single-dose irradiation with 20 Gy was investigated using U87MG tumors in nude mice. RESULTS: Lovastatin dose dependently decreased cell number and proliferation of U87MG and FaDu cells. The proportion of cells in G0/G1 phase, apoptosis and p21 protein expression increased after lovastatin alone or combined with 4-Gy irradiation in both cell lines. Effects of lovastatin on cell cycle and cell number were more pronounced in U87MG compared to FaDu. No radiosensitization of clonogenic cells by lovastatin could be demonstrated in both cells lines, but the colony-forming ability after lovastatin alone was decreased in FaDu cells. In vivo, lovastatin decreased tumor volume over time but did not increase growth delay after irradiation of U87MG tumors with 20 Gy. CONCLUSION: The data support effects of lovastatin on proliferation, apoptosis and colony-forming ability in vitro and tumor volume in vivo. At the drug concentration achievable, lovastatin did not improve the effects of radiation on U87MG tumors in vivo. 相似文献
3.
LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus 总被引:9,自引:0,他引:9
Gramberg T Hofmann H Möller P Lalor PF Marzi A Geier M Krumbiegel M Winkler T Kirchhoff F Adams DH Becker S Münch J Pöhlmann S 《Virology》2005,340(2):265-236
Cellular attachment factors like the C-type lectins DC-SIGN and DC-SIGNR (collectively referred to as DC-SIGN/R) can augment viral infection and might promote viral dissemination in and between hosts. The lectin LSECtin is encoded in the same chromosomal locus as DC-SIGN/R and is coexpressed with DC-SIGNR on sinusoidal endothelial cells in liver and lymphnodes. Here, we show that LSECtin enhances infection driven by filovirus glycoproteins (GP) and the S protein of SARS coronavirus, but does not interact with human immunodeficiency virus type-1 and hepatitis C virus envelope proteins. Ligand binding to LSECtin was inhibited by EGTA but not by mannan, suggesting that LSECtin unlike DC-SIGN/R does not recognize high-mannose glycans on viral GPs. Finally, we demonstrate that LSECtin is N-linked glycosylated and that glycosylation is required for cell surface expression. In summary, we identified LSECtin as an attachment factor that in conjunction with DC-SIGNR might concentrate viral pathogens in liver and lymph nodes. 相似文献
4.
Joncourt F Neuhaus B Jostarndt-Foegen K Kleinle S Steiner B Gallati S 《Human mutation》2004,23(4):385-391
Recently developed PCR systems offer online-monitoring of amplification and allow simple and reliable DNA quantification. We have used the LightCycler system to develop a simple and rapid method for direct identification of female carriers of deletions and duplications in the dystrophin gene. The challenge resides in the ability to identify the presence of a deleted or duplicated allele over the background contributed by the normal allele. Quantification is based on the determination of the ratio between potentially deleted/duplicated dystrophin exons and non-deleted/-duplicated reference exons using the unspecific dsDNA-dye SYBRgreen I. In a retrospective study, we evaluated our method in female relatives of DMD/BMD patients with known carrier status by comparative analysis of deleted or duplicated versus non-deleted/-duplicated exons. Carrier status was accurately attributed in 100% of cases, the mean ratios being 0.52+/-0.12 for deletion carriers (expected value: 0.5) and 1.56+/-0.18 for duplication carriers (expected value: 1.5) vs. 1.022+/-0.17 for non-carriers (expected value: 1.0). The method proved to be simple, rapid, reliable, and cost-effective. It may be used for direct determination of deletions/duplications in potential DMD/BMD carriers and may easily be adapted for other genetic conditions involving deletions and duplications. 相似文献
5.
Postextrasystolic regulation patterns of blood pressure and heart rate in patients with idiopathic dilated cardiomyopathy 总被引:12,自引:0,他引:12
Andreas Voss Vico Baier Agnes Schumann Annette Hasart Franziska Reinsperger Alexander Schirdewan Karl-Josef Osterziel Uwe Leder† 《The Journal of physiology》2002,538(1):271-278
Assessment of fluctuations in heart rate (HR) following a premature ventricular complex (PVC) is valuable for identifying patients at high risk of sudden cardiac death. We hypothesised that postextrasystolic potentiation is the main determinant of the regulation patterns of blood pressure (BP) and HR following a PVC. Twelve patients with idiopathic dilated cardiomyopathy (IDC) and 13 control subjects with single PVCs (comparable coupling intervals) were investigated. Non-invasive finger arterial BP and ECGs were analysed. Regulation patterns following a single PVC were quantified using the indices postextrasystolic amplitude potentiation (PEAP) and maximum turbulence slope of five consecutive mean BP values (MBP-TS), and compared with the HR turbulence parameters turbulence slope (HR-TS) and turbulence onset (HR-TO). PEAP was significantly higher in IDC patients compared to controls (48.7 ± 32.6 vs. 9.8 ± 5.4 %, P < 0.01), whereas MBP-TS was lower (0.97 ± 0.60 vs. 2.07 ± 1.04 mmHg BBI−1 (BBI, beat-to-beat interval), P < 0.05), as was HR-TS (8.46 ± 7.90 vs. 30.73 ± 22.90 ms BBI−1 , P < 0.01). HR-TO was significantly higher in IDC patients (−0.56 ± 2.19 vs. −5.52 ± 4.13 %, P < 0.01). In addition, the regulation patterns of BP and HR following a single PVC differed significantly between IDC patients and controls. Specifically, we observed pronounced PEAPs in IDC patients. The baroreflex response initiated by the low pressure amplitude of the PVC was suppressed in IDC patients due to the augmented potentiation of the first postextrasystolic blood pressure. Furthermore, IDC patients displayed impressive postextrasystolic pulsus alternans phenomena, whereas healthy subjects exhibited a typical baroreflex pattern. The pulsus alternans phenomenon seems to be triggered by a PVC. 相似文献
6.
Krumbiegel D Rohr J Schmidtke P Knuf M Zepp F Meyer CU 《Clinical & developmental immunology》2005,12(2):99-105
Specific functional properties of dendritic cells (DCs) have been suspected as being responsible for the impaired specific immune responses observed in human neonates. To analyze stimulatory requirements for the critical transition from immature, antigen-processing DCs to mature, antigen-presenting DCs, we investigated the effect of different proinflammatory mediators and antigens on phenotype and cytokine secretion of human neonatal DCs derived from hematopoietic progenitor cells (HPCs). Whereas single proinflammatory mediators were unable to induce the maturation of neonatal DCs, various combinations of IFNgamma, CD40L, TNFalpha, LPS and antigens, induced the maturation of neonatal DCs documented by up-regulation of HLA-DR, CD83 and CD86. Combinations of proinflammatory mediators also increased cytokine secretion by neonatal DCs. Especially combined stimulation with LPS and IFNgamma proved to be very efficient in inducing maturation and cytokine synthesis of neonatal DCs. In conclusion, neonatal DCs can be stimulated to express maturation as well as costimulatory surface molecules. However, induction of maturation requires combined stimulation with multiple proinflammatory signals. 相似文献
7.
The pitch identification performance of absolute pitch possessors has previously been shown to depend on pitch range, key color, and timbre of presented tones. In the present study, the dependence of pitch identification performance on key color and timbre of musical tones was examined by analyzing hit rates, reaction times, and pupillary responses of absolute pitch possessors (n = 9) and nonpossessors (n = 12) during a pitch identification task. Results revealed a significant dependence of pitch identification hit rate but not reaction time on timbre and key color in both groups. Among absolute pitch possessors, peak dilation of the pupil was significantly dependent on key color whereas the effect of timbre was marginally significant. Peak dilation of the pupil differed significantly between absolute pitch possessors and nonpossessors. The observed effects point to the importance of learning factors in the acquisition of absolute pitch. 相似文献
8.
Kainz Elena Stuff Karin Kahl Ursula Wiessner Christian Yu Yuanyuan von Breunig Franziska Nitzschke Rainer Haese Alexander Graefen Markus Fischer Marlene 《Quality of life research》2022,31(8):2397-2410
Quality of Life Research - The objective of this study was to determine the influence of postanesthesia care unit (PACU) delirium on self-reported cognitive function and perceived health... 相似文献
9.
Mastella Giulio Darstein Lars Raufhake Carsten Schneider Vera Corletto Anna Buiatti Alessandra Mller Alexander Schuessler-Hahn Franziska Gondert Markus Gerdes Heiko Martens Eimo 《Zeitschrift fur Gesundheitswissenschaften》2022,30(1):5-10
Journal of Public Health - Offshore wind energy is a fast growing market. Accordingly, a correspondingly large number of employees are working at the wind farms. Owing to the harsh operating... 相似文献
10.
Thamm Roma Buttmann-Schweiger Nina Fiebig Julia Poethko-Müller Christina Prütz Franziska Sarganas Giselle Neuhauser Hannelore 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2021,64(12):1483-1491
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - SARS-CoV-2-Antikörperstudien ergänzen und erweitern die Erkenntnisse aus der Meldestatistik laborbestätigter... 相似文献