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Gouveia TL Scorza FA Silva MJ Bandeira Tde A Perosa SR Argañaraz GA Silva Mde P Araujo TR Frangiotti MI Amado D Cavalheiro EA Silva JA Naffah-Mazzacoratti Mda G 《Epilepsy & behavior : E&B》2011,20(1):1-5
Statins may act on inflammatory responses, decreasing oxidative stress and also reducing temperature after a brain ischemic insult. Previous data have indicated that statins protect neurons from death during long-lasting status epilepticus (SE) and attenuate seizure behaviors in animals treated with kainic acid. In this context, the study described here aimed to investigate the effect of lovastatin on body temperature and on mRNA expression levels of hippocampal cytokines such as interleukin-1β, interleukin-6, tumor necrosis factor α, and kinin B1 and B2 receptors of rats submitted to pilocarpine-induced SE. Quantitative real-time polymerase chain reaction showed a significant decrease in mRNA expression of interleukin-1β, interleukin-6, tumor necrosis factor α, and kinin B1 receptor in animals with SE treated with lovastatin, compared with untreated animals with SE (P<0.001). Lovastatin also reduced SE-induced hyperthermia, indicating that mechanisms related to brain protection are triggered by this drug under conditions associated with acute excitotoxicity or long-lasting SE. 相似文献
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Raso Júlia Santos Lincoln Marques Cavalcante Reis Débora Alves Frangiotti Marília Amaral Costa Zanetti Ariane Cristina Barboza Capucho Helaine Carneiro Herdeiro Maria Teresa Roque Fátima Pereira Leonardo Régis Leira Varallo Fabiana Rossi 《International journal of clinical pharmacy》2022,44(2):548-556
International Journal of Clinical Pharmacy - Background Although delirium is one of the most common adverse drug reactions observed in hospitalized older people, it remains underdiagnosed. Aim To... 相似文献
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