全文获取类型
收费全文 | 1572篇 |
免费 | 109篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 52篇 |
妇产科学 | 74篇 |
基础医学 | 225篇 |
口腔科学 | 14篇 |
临床医学 | 179篇 |
内科学 | 232篇 |
皮肤病学 | 42篇 |
神经病学 | 220篇 |
特种医学 | 28篇 |
外科学 | 291篇 |
综合类 | 7篇 |
预防医学 | 55篇 |
眼科学 | 15篇 |
药学 | 99篇 |
肿瘤学 | 137篇 |
出版年
2023年 | 9篇 |
2022年 | 9篇 |
2021年 | 13篇 |
2020年 | 9篇 |
2019年 | 16篇 |
2018年 | 23篇 |
2017年 | 15篇 |
2016年 | 21篇 |
2015年 | 23篇 |
2014年 | 29篇 |
2013年 | 35篇 |
2012年 | 56篇 |
2011年 | 81篇 |
2010年 | 42篇 |
2009年 | 33篇 |
2008年 | 80篇 |
2007年 | 83篇 |
2006年 | 89篇 |
2005年 | 81篇 |
2004年 | 71篇 |
2003年 | 90篇 |
2002年 | 52篇 |
2001年 | 53篇 |
2000年 | 66篇 |
1999年 | 48篇 |
1998年 | 29篇 |
1997年 | 26篇 |
1996年 | 14篇 |
1995年 | 9篇 |
1994年 | 12篇 |
1993年 | 14篇 |
1992年 | 17篇 |
1991年 | 16篇 |
1990年 | 20篇 |
1989年 | 22篇 |
1988年 | 18篇 |
1987年 | 13篇 |
1986年 | 15篇 |
1985年 | 17篇 |
1984年 | 14篇 |
1983年 | 9篇 |
1982年 | 9篇 |
1979年 | 19篇 |
1977年 | 15篇 |
1975年 | 8篇 |
1974年 | 10篇 |
1972年 | 9篇 |
1971年 | 7篇 |
1967年 | 7篇 |
1966年 | 10篇 |
排序方式: 共有1683条查询结果,搜索用时 15 毫秒
1.
James R. Westphal 《International journal of mental health and addiction》2007,5(2):123-140
Introduction Recent reviews found problem gamblers are heterogeneous and recommended subtyping gamblers in treatment studies.
Objective Review factors (stage of change, preferred gambling activity, co-occurring disorder, and temporal instability of symptoms)
for subtyping by evaluating the evidence for their effects on gambling treatment.
Methods Literature review, evidence grading.
Results Evidence is limited that any of the reviewed factors affects gambling treatment. Substantial evidence from prospective studies
and other evidence from cross-sectional studies and the strong placebo response among pathological gamblers support the temporal
instability of gambling symptoms.
Conclusions Multiple studies are needed to develop the evidence base needed to subtype gamblers in treatment. Changes in the diagnostic
criteria of pathological gambling may be necessary, especially to specify the persistence of gambling-related symptoms. 相似文献
2.
3.
Ohne Zusammenfassung 相似文献
4.
Anneloes Dirks Lucianne Groenink Koen G C Westphal Jocelien D A Olivier P Monika Verdouw Jan van der Gugten Mark A Geyer Berend Olivier 《Neuropsychopharmacology》2003,28(10):1790-1798
Chronically elevated levels of corticotropin-releasing factor (CRF) in transgenic mice overexpressing CRF in the brain (CRF-OE) appear to be associated with alterations commonly associated with major depressive disorder, as well as with sensorimotor gating deficits commonly associated with schizophrenia. In the present study, we tested the hypothesis that antipsychotics may be effective in normalizing prepulse inhibition (PPI) of acoustic startle in CRF-OE mice, which display impaired sensorimotor gating compared to wild-type (WT) mice. The typical antipsychotic haloperidol and atypical antipsychotic risperidone improved PPI in the CRF-OE mice, but were ineffective in WT mice. The atypical antipsychotic clozapine did not influence PPI in CRF-OE mice, but reduced gating in WT mice. This effect of clozapine in the CRF-OE mice may thus be regarded as a relative improvement, consistent with the observed effect of haloperidol and risperidone. As expected, the anxiolytic, nonantipsychotic chlordiazepoxide was devoid of any effect. All four compounds dose-dependently reduced the acoustic startle response irrespective of genotype. These results indicate that antipsychotic drugs are effective in improving startle gating deficits in the CRF-OE mice. Hence, the CRF-OE mouse model may represent an animal model for certain aspects of psychotic depression, and could be a valuable tool for research addressing the impact of chronically elevated levels of CRF on information processing. 相似文献
5.
Modification of cefixime bioavailability by nifedipine in humans: involvement of the dipeptide carrier system. 下载免费PDF全文
C Duverne A Bouten A Deslandes J F Westphal J H Trouvin R Farinotti C Carbon 《Antimicrobial agents and chemotherapy》1992,36(11):2462-2467
We studied the action of nifedipine on the bioavailability of cefixime, a molecule absorbed via the gut wall dipeptide carrier system in the rat, and on the bioavailability of D-xylose, which is absorbed via a pH (and Na(+)-)-dependent transporter. Each compound was administered alone or in combination with 20 mg of nifedipine to eight healthy male volunteers. Nifedipine significantly increased the absorption rate of cefixime (20.7 +/- 4.3 versus 16 +/- 3.5 mg/h in the absence of nifedipine). The absolute bioavailability of cefixime alone was 31% +/- 6% compared with 53% +/- 1% (P < 0.01) in the presence of nifedipine. The observed peak concentrations in serum were significantly different (2.5 +/- 0.3 mg/liter without nifedipine and 3.7 +/- 1.1 mg/liter with nifedipine; P < 0.02). In contrast, nifedipine induced no significant differences in the pharmacokinetic profile of xylose following oral administration. We conclude that (i) cefixime is absorbed in humans by an apparently active process which can be enhanced by a calcium channel blocker, in this case, nifedipine; and (ii) nifedipine does not modify the activity of the pentose transporter. 相似文献
6.
7.
In the case of characteristic chromosomal deletion of chromosome 15(q11----q13) the diagnosis of the Prader-Willi syndrome can be already confirmed in early infancy as shown in our case report. In this connection cytogenetic high-resolution techniques are indispensable. Cytogenetic and clinical problems are discussed. 相似文献
8.
9.
10.