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B G Redman L Flaherty S Martino M Kraut C Wisniewski M Valdivieso J J Bander 《American journal of clinical oncology》1992,15(4):340-343
Administration of high-dose IL-2 results in hemodynamic changes that are similar to those seen in septic shock. These include a decrease in systemic vascular resistance (SVR) with a resultant drop in mean arterial pressure (MAP). Hypocalcemia is seen in septic shock and with IL-2 administration. Calcium replacement in septic shock has been reported to result in hemodynamic improvement; we therefore administered calcium to patients receiving high dose IL-2 to correct ionized hypocalcemia. Five consecutive patients underwent invasive hemodynamic monitoring before and during IL-2 administration. Calcium chloride was administered to correct ionized hypocalcemia, and hemodynamic parameters were monitored before and after calcium administration. Ionized hypocalcemia was associated with an elevation in parathyroid hormone levels. There was no toxicity related to the administration of calcium. An improvement in the MAP and SVR was seen early and late (after a dose of IL-2 was held) in the IL-2 treatment cycle; there were minimal effects at other points. Because of the potential hemodynamic benefit of calcium replacement, we recommend that ionized hypocalcemia be corrected in patients receiving high-dose IL-2. 相似文献
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Rao G Flaherty P 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》1989,16(3):163-168
Of the total number of pacemakers implanted each year, 6% must eventually be replaced because of infection, lead failure, or other problems. Often however, removal of the pacing leads is precluded by scarring at the tip of the leads. Because abandoned leads can cause serious problems, we initiated the present study to test the feasibility of using a laser to remove such leads. After performing in vitro experiments to establish the laser settings required for severing leads, we implanted 6 leads, from 4 different manufacturers, in 3 dogs. Five weeks later, we passed a laser fiber through each lead to the tip and delivered a 10-watt impulse for 2 seconds, which resulted in the successful removal of all the leads. When the dogs were killed 3 days later, postmortem examination revealed no thromboembolism in the heart or lungs and no myocardial damage. Subsequent experiments in 3 human cadaver hearts-involving leads implanted for 5 years, 2 years, and 2 months-yielded the same satisfactory results as did the canine experiments. 相似文献
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Krushkal J; Xiong M; Ferrell R; Sing CF; Turner ST; Boerwinkle E 《Human molecular genetics》1998,7(9):1379-1383
Elevated blood pressure is an important risk factor for renal-, cerebro-
and cardiovascular diseases. We used an efficient discordant sib-pair
ascertainment scheme to investigate the impact of the distal end of the
long arm of human chromosome 5 (chromosomal region 5q31.1-qter) containing
genes for the alpha1B and beta2 adrenergic receptors and the dopamine
receptor type 1A on variation of systolic blood pressure in young
Caucasians. We measured eight highly polymorphic markers spanning this
positional candidate gene-rich region in 427 individuals from 55
three-generation pedigrees containing 69 discordant sibling pairs, and
calculated multipoint identity by descent (MIBD) probabilities. The results
of genetic linkage and association tests indicate that the region between
markers D5S2093 and D5S462 is significantly linked to one or more
polymorphic genes influencing interindividual variation in systolic blood
pressure levels. Since the alpha1B adrenergic receptor and dopamine
receptor type 1A genes are located close to these markers, these data
suggest that genetic variation in one or both of these G protein-coupled
receptors, which participate in the control of vascular tone, plays an
important role in influencing interindividual variation in systolic blood
pressure levels.
相似文献
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An evaluation of commercial radioisotope methods for the determination of folate and vitamin B12. 下载免费PDF全文
D W Dawson I W Delamore D I Fish T A Flaherty A H Gowenlock L P Hunt K Hyde J E MacIver J A Thornton H M Waters 《Journal of clinical pathology》1980,33(3):234-242
Five commercial kits for the determination of folate and six kits for the determination of vitamin B12 were investigated. Their performance has been compared with microbiological methods for the two vitamins and with a non-commercial radioisotopic method for B12. The results show the importance of the determination of the reference range for an individual laboratory for each method. The precision of the kits varied appreciably, as did their performance using specimens from patients with different haematological disorders. In particular, certain kits failed to detect all patients with pernicious anaemia. The relative accuracy of the kits was assessed. Various factors which should be taken into account in the final selection of a satisfactory kit are discussed. 相似文献