全文获取类型
收费全文 | 7202篇 |
免费 | 286篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 155篇 |
儿科学 | 270篇 |
妇产科学 | 286篇 |
基础医学 | 929篇 |
口腔科学 | 81篇 |
临床医学 | 469篇 |
内科学 | 1845篇 |
皮肤病学 | 82篇 |
神经病学 | 675篇 |
特种医学 | 101篇 |
外科学 | 571篇 |
综合类 | 61篇 |
一般理论 | 1篇 |
预防医学 | 589篇 |
眼科学 | 210篇 |
药学 | 740篇 |
中国医学 | 11篇 |
肿瘤学 | 439篇 |
出版年
2023年 | 44篇 |
2022年 | 117篇 |
2021年 | 252篇 |
2020年 | 98篇 |
2019年 | 122篇 |
2018年 | 151篇 |
2017年 | 150篇 |
2016年 | 164篇 |
2015年 | 167篇 |
2014年 | 229篇 |
2013年 | 345篇 |
2012年 | 465篇 |
2011年 | 505篇 |
2010年 | 294篇 |
2009年 | 223篇 |
2008年 | 363篇 |
2007年 | 459篇 |
2006年 | 427篇 |
2005年 | 426篇 |
2004年 | 429篇 |
2003年 | 388篇 |
2002年 | 363篇 |
2001年 | 58篇 |
2000年 | 61篇 |
1999年 | 68篇 |
1998年 | 91篇 |
1997年 | 53篇 |
1996年 | 57篇 |
1995年 | 59篇 |
1994年 | 45篇 |
1993年 | 42篇 |
1992年 | 47篇 |
1991年 | 35篇 |
1990年 | 39篇 |
1989年 | 52篇 |
1988年 | 44篇 |
1987年 | 32篇 |
1986年 | 29篇 |
1985年 | 24篇 |
1984年 | 28篇 |
1983年 | 24篇 |
1982年 | 22篇 |
1981年 | 26篇 |
1980年 | 22篇 |
1977年 | 33篇 |
1976年 | 22篇 |
1975年 | 33篇 |
1974年 | 43篇 |
1973年 | 35篇 |
1966年 | 25篇 |
排序方式: 共有7515条查询结果,搜索用时 15 毫秒
1.
Bień Agnieszka Rzońca Ewa Zarajczyk Marta Wilkosz Katarzyna Wdowiak Artur Iwanowicz-Palus Grażyna 《Quality of life research》2020,29(10):2669-2677
Quality of Life Research - The aim of the study was to assess QoL and identify and analyse its determinants in women with endometriosis. The study was performed in 2019 in health centres in Lublin... 相似文献
2.
3.
Ewelina Kazimierczyk Andrzej Eljaszewicz Paula Zembko Ewa Tarasiuk Malgorzata Rusak Agnieszka Kulczynska-Przybik Marta Lukaszewicz-Zajac Karol Kaminski Barbara Mroczko Maciej Szmitkowski Milena Dabrowska Bozena Sobkowicz Marcin Moniuszko Agnieszka Tycinska 《Pharmacological reports : PR》2019,71(1):73-81
Background
Acute myocardial infarction (AMI) causes irreversible myocardial damage and release of inflammatory mediators, including cytokines, chemokines and miRNAs. We aimed to investigate changes in the levels of cytokines (IL-6, TNF-α and IL-10), miRNAs profiles (miR-146 and miR-155) and distribution of different monocyte subsets (CD14++CD16-, CD14++CD16+, CD14+CD16++) in the acute and post-healing phases of AMI.Methods
In eighteen consecutive AMI patients (mean age 56.78?±?12.4 years, mean left ventricle ejection fraction – LVEF: 41.9?±?9.8%), treated invasively, monocyte subsets frequencies were evaluated (flow cytometry), cytokine concentrations were analyzed (ELISA) as well as plasma miRNAs were isolated twice – on admission and after 19.2?±?5.9 weeks of follow-up. Measurements were also performed among healthy volunteers.Results
AMI patients presented significantly decreased frequencies of classical cells in comparison to healthy controls (median 71.22% [IQR: 64.4–79.04] vs. 84.35% [IQR: 81.2–86.7], p?=?0.001) and higher percent of both intermediate and non-classical cells, yet without statistical significance (median 6.54% [IQR: 5.14–16.64] vs. 5.87% [IQR: 4.48–8.6], p?=?0.37 and median 5.99% [IQR: 3.39–11.5] vs. 5.26% [IQR: 3.62–6.2], p?=?0.42, respectively). In AMI patients both, analyzed plasma miRNA concentrations were higher than in healthy subjects (miR-146: median 5.48 [IQR: 2.4–11.27] vs. 1.84 [IQR: 0.87–2.53], p?=?0.003; miR-155: median 25.35 [IQR: 8.17–43.15] vs. 8.4 [IQR: 0.08–16.9], p?=?0.027, respectively), and returned back to the values found in the control group in follow-up. miR-155/miR-146 ratio correlated with the frequencies of classical monocytes (r=0.6, p?=?0.01) and miR-155 correlated positively with the concentration of inflammatory cytokines ? IL-6 and TNF-α.Conclusions
These results may suggest cooperation of both pro-inflammatory and anti-inflammatory signals in AMI in order to promote appropriate healing of the infarcted myocardium. 相似文献4.
5.
Mr. Charles V. Clark M.D. David J. Ewing 《Documenta ophthalmologica. Advances in ophthalmology》1988,70(4):309-321
Ocular autonomic function was assessed in 4 patients with progressive autonomic failure (PAF) and age-matched control subjects, by measurement of the pupil cycle time, and determination of autonomic denervation hypersensitivity of the iris. Pupil cycle time was abnormal in all patients with PAF; sustained pupil cycling was absent in 5 of the 8 eyes tested of the PAF patients, compared with only 16 eyes from 70 control subjects. Pupil constriction in response to 2.5% methacholine, indicative of parasympathetic denervation hypersensitivity, was significantly increased in patients with PAF (p < 0.001), whilst pupil dilation in response to 0.5% phenylephrine, indicative of sympathetic denervation hypersensitivity, was also significantly higher in the PAF patients (p < 0.001). The results suggest that ocular autonomic function may provide a sensitive early indicator of generalised autonomic dysfunction. 相似文献
6.
The treatment options of patients with urge incontinence are behavioral therapy, drug therapy and surgery. The evaluation and reported efficacy of these treatments, with particular reference to the potential placebo response in treatment is discussed. 相似文献
7.
The incidence of lower urinary tract dysfunction increases during the climacteric, and there is embryological, biochemical and epidemiologic evidence to suggest that depleted estrogen status is at least partially responsible. Twelve climacteric women underwent full assessment before and 1 year after treatment with a 50 mg subcutaneous estradiol implant +5 mg norethisterone for 7 days per month. Assessment consisted of a symptoms questionnaire, midstream urine sample, uroflowmetry, videocystourethrography with pressure flow studies, and urethral pressure profilometry. Subjectively, only the symptom of nocturia significantly improved. There was no change in flow variables but there was a significant decrease in residual urine and the degree of bladder base descent. Cystometric capacity was slightly but significantly decreased, and two patients developed genuine stress incontinence whilst on treatment. Nonetheless, there was a significant improvement in urethral pressures at rest but not under stress. This effect was predominantly in the proximal urethra. These data do not support the contention that estrogen replacement therapy is beneficial for lower urinary tract dysfunction during the climacteric. 相似文献
8.
9.
Marcela Hernández Hoyos Piotr Orłowski Ewa Piątkowska-Janko Piotr Bogorodzki Maciej Orkisz 《International journal of computer assisted radiology and surgery》2006,1(1):51-61
The accuracy of 2D phase contrast (PC) magnetic resonance angiography (MRA) depends on the alignment between the vessels and
the imaging plane. PC MRA imaging of blood flow is challenging when the flow in several vessels is to be evaluated with one
acquisition. For this purpose, semi-automatic determination of the plane most perpendicular to several vessels is proposed
based on centerlines extracted from 3D MRA. Arterial centerlines are extracted from 3D MRA based on iterative estimation-prediction,
multi-scale analysis of image moments, and a second-order shape model. The optimal plane is determined by minimizing misalignment
between its normal vector and the centerlines’ tangent vectors. The method was evaluated on a phantom and on 35 patients,
by seeking the optimal plane for cerebral blood flow quantification simultaneously in internal carotids and vertebral arteries.
In the phantom, difference of orientation and of height between known and calculated planes was 1.2° and 2.5 mm, respectively.
In the patients, all but one centerline were correctly extracted and the misalignment of the plane was within 12° per artery.
Semi-automatic centerline extraction simplifies and automates determination of the plane orthogonal to one vessel, thereby
permitting automatic simultaneous minimization of the misalignment with several vessels in PC MRA. 相似文献
10.
Dr. Sandra S. Garner Pharm.D. Dr. Donald B. Wiest Pharm.D. Mr. J. Warren Bradley R.R.T. 《Pharmacotherapy》1994,14(2):210-214
Study Objective . To determine albuterol delivery by metered-dose inhaler (MDI) in an in vitro pediatric mechanical ventilatory circuit model. The influence of a spacing device, endotracheal tube (ETT) diameter and length, and air humidity was also investigated. Design . An albuterol MDI canister was connected to an AeroVent spacer or Airlife MDI adapter and ETT 4.0, 5.0, or 6.0 mm at commercially available and equal lengths. The ETT tip was attached to an in-line filter holder with a 1-μm type A/E glass fiber filter. Ventilator settings were fractional concentration of inspired oxygen 50%, tidal volume 250 ml, inspiratory:expiratory (I:E) ratio 1:3, rate 25 breaths/minute, temperature 35°C, and a decelerating flow pattern. Ten albuterol canisters were activated two times each (total 2000 μg) into dry (4.0-, 5.0-, and 6.0-mm ETT) and humidified air (4.0- and 6.0-mm ETT) and repeated in triplicate. Percentage MDI output was determined by weighing the filter before and after drug administration (balance sensitivity 10 μg). Significant differences (p≤0.05) among the groups with and without a spacer and in dry and humidified air were determined by ANOVA with Scheffe's multiple comparison test. Multiple regression was used to determine significant associations between ETT diameter and length and delivery. Main Results . With the AeroVent spacer in humidified air, delivery with the 4.0- and 6.0-mm ETT was approximately 2.3% and 5%, respectively. The spacer and dry air significantly improved delivery. Conclusions . In humidified air, the dose of albuterol by MDI with an AeroVent spacer should be doubled for children intubated with 6.0-mm ETT, and four puffs administered for every one puff desired for 4.0-mm ETT. The results of this investigation should prove useful in initial clinical trials of albuterol MDI in ventilator-dependent infants and children. 相似文献