全文获取类型
收费全文 | 8190篇 |
免费 | 559篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 294篇 |
妇产科学 | 262篇 |
基础医学 | 1298篇 |
口腔科学 | 220篇 |
临床医学 | 759篇 |
内科学 | 1724篇 |
皮肤病学 | 302篇 |
神经病学 | 749篇 |
特种医学 | 218篇 |
外科学 | 712篇 |
综合类 | 47篇 |
一般理论 | 3篇 |
预防医学 | 806篇 |
眼科学 | 76篇 |
药学 | 590篇 |
中国医学 | 30篇 |
肿瘤学 | 644篇 |
出版年
2023年 | 58篇 |
2022年 | 95篇 |
2021年 | 206篇 |
2020年 | 196篇 |
2019年 | 238篇 |
2018年 | 252篇 |
2017年 | 202篇 |
2016年 | 234篇 |
2015年 | 273篇 |
2014年 | 337篇 |
2013年 | 434篇 |
2012年 | 669篇 |
2011年 | 662篇 |
2010年 | 368篇 |
2009年 | 312篇 |
2008年 | 531篇 |
2007年 | 537篇 |
2006年 | 526篇 |
2005年 | 477篇 |
2004年 | 415篇 |
2003年 | 388篇 |
2002年 | 332篇 |
2001年 | 83篇 |
2000年 | 63篇 |
1999年 | 59篇 |
1998年 | 69篇 |
1997年 | 52篇 |
1996年 | 49篇 |
1995年 | 37篇 |
1994年 | 32篇 |
1993年 | 28篇 |
1992年 | 36篇 |
1991年 | 37篇 |
1990年 | 35篇 |
1989年 | 24篇 |
1988年 | 28篇 |
1987年 | 23篇 |
1986年 | 29篇 |
1985年 | 27篇 |
1984年 | 14篇 |
1983年 | 15篇 |
1982年 | 24篇 |
1981年 | 23篇 |
1979年 | 14篇 |
1978年 | 16篇 |
1977年 | 14篇 |
1976年 | 15篇 |
1974年 | 14篇 |
1971年 | 14篇 |
1967年 | 13篇 |
排序方式: 共有8777条查询结果,搜索用时 15 毫秒
1.
2.
3.
Very preterm children are at increased risk of reduced processing speed at 5 years of age,predicted by typical complications of prematurity and prenatal smoking
下载免费PDF全文
![点击此处可从《Acta paediatrica (Oslo, Norway : 1992)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
4.
Erik de Bakker Mirthe A. M. van der Putten Martijn W. Heymans Sander W. Spiekstra Taco Waaijman Liselotte Butzelaar Vera L. Negenborn Vivian K. Beekman Erman O. Akpinar Thomas Rustemeyer Frank B. Niessen Susan Gibbs 《Experimental dermatology》2021,30(1):169-178
Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) immunological differences exist between patients who develop HS and those who develop normotrophic scars (NS) and to assess whether those differences can be used to identify patients prone to developing HS. A prospective cohort study with NS and HS groups in which (a) cytokine release by peripheral blood mononuclear cells (PBMC) and (b) the irritation threshold (IT) after an irritant (sodium lauryl sulphate) patch test was evaluated. Univariate regression analysis of PBMC cytokine secretion showed that low MCP‐1, IL‐8, IL‐18 and IL‐23 levels have a strong correlation with HS (P < .010‐0.004; AUC = 0.790‐0.883). Notably, combinations of two or three cytokines (TNF‐a, MCP‐1 and IL‐23; AUC: 0.942, Nagelkerke R2: 0.727) showed an improved AUC indicating a better correlation with HS than single cytokine analysis. These combination models produce good prognostic results over a broad probability range (sensitivity: 93.8%, specificity 86.7%, accuracy 90,25% between probability 0.3 and 0.7). Furthermore, the HS group had a lower IT than the NS group and an accuracy of 68%. In conclusion, very fundamental immunological differences exist between individuals who develop HS and those who do not, whereas the cytokine assay forms the basis of a predictive prognostic test for HS formation, the less invasive, easily performed irritant skin patch test is more accessible for daily practice. 相似文献
5.
6.
7.
Ebadi Maryam Bhanji Rahima A. Mazurak Vera C. Montano-Loza Aldo J. 《Journal of gastroenterology》2019,54(10):845-859
Journal of Gastroenterology - Sarcopenia (severe muscle depletion) is a prevalent muscle abnormality in patients with cirrhosis that confers poor prognosis both pre- and post-liver transplantation.... 相似文献
8.
Effects of repetitive TMS on visually evoked potentials and EEG in the anaesthetized cat: dependence on stimulus frequency and train duration 总被引:2,自引:0,他引:2
Selcen Aydin-Abidin Vera Moliadze Ulf T. Eysel Klaus Funke 《The Journal of physiology》2006,574(2):443-455
Repetitive transcranial magnetic stimulation (rTMS) has been shown to alter cortical excitability that lasts beyond the duration of rTMS application itself. High-frequency rTMS leads primarily to facilitation, whereas low-frequency rTMS leads to inhibition of the treated cortex. However, the contribution of rTMS train duration is less clear. In this study, we investigated the effects of nine different rTMS protocols, including low and high frequencies, as well as short and long applications (1, 3 and 10 Hz applied for 1, 5 and 20 min), on visual cortex excitability in anaesthetized and paralysed cats by means of visual evoked potential (VEP) and electroencephalography (EEG) recordings. Our results show that 10 Hz rTMS applied for 1 and 5 min significantly enhanced early VEP amplitudes, while 1 and 3 Hz rTMS applied for 5 and 20 min significantly reduced them. No significant changes were found after 1 and 3 Hz rTMS applied for only 1 min, and 10 Hz rTMS applied for 20 min. EEG activity was only transiently (<20 s) affected, with increased delta activity after 1 and 3 Hz rTMS applied for 1 or 5 min. These findings indicate that the effects of rTMS on cortical excitability depend on the combination of stimulus frequency and duration (or total number of stimuli): short high-frequency trains seem to be more effective than longer trains, and low-frequency rTMS requires longer applications. Changes in the spectral composition of the EEG were not correlated to changes in VEP size. 相似文献
9.
Andressa A.F.L. Maciel Reinaldo B. Ori Manuel B. Braga-Neto Andra B. Braga Eunice B. Carvalho Herene B.M. Lucena Gerly A.C. Brito Richard L. Guerrant Aldo A.M. Lima 《Toxicon》2007,50(8):1027-1040
Vitamin A (retinol), a fat-soluble vitamin, is an essential nutrient for the normal functioning of the visual system, epithelial cell integrity and growth, immunity, and reproduction. Our group has investigated the effect of high doses of oral vitamin A on early childhood diarrhea in our prospective community-based studies from Northeast Brazil and found a beneficial role in reducing the mean duration but not incidence of diarrheal episodes. In this study, we explored the role of retinol supplementation in intestinal cell lines following Clostridium difficile toxin A (TxA) challenge. C. difficile is the most common anaerobic pathogen borne with antibiotic-borne diarrhea and pseudomembranous colitis. Since retinol is critical for the integrity of tight junctions and to modulate the cell cycle, we have focused on changes in transepithelial electrical resistance (TEER) in Caco-2, a more differentiated intestinal cell line, and on models of cell proliferation, migration and viability in IEC-6 cells, an undifferentiated crypt cell line, following TxA injury. In this model, retinol therapy reduced apoptosis, improved cell migration and proliferation, and prevented the reduction in TEER, following C. difficile TxA challenge in a glutamine-free medium. These results suggest the role of retinol in protecting intestinal epithelial barrier function from C. difficile TxA enterotoxic damage. 相似文献
10.
Borras Merce; Valdivielso Jose M.; Egido Ramon; Vicente de Vera Pilar; Bordalba Josep Ramon; Fernandez Elvira 《Nephrology, dialysis, transplantation》2006,21(3):789-791