全文获取类型
收费全文 | 2915篇 |
免费 | 239篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 81篇 |
妇产科学 | 50篇 |
基础医学 | 508篇 |
口腔科学 | 11篇 |
临床医学 | 303篇 |
内科学 | 641篇 |
皮肤病学 | 66篇 |
神经病学 | 361篇 |
特种医学 | 63篇 |
外科学 | 352篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 207篇 |
眼科学 | 45篇 |
药学 | 172篇 |
中国医学 | 1篇 |
肿瘤学 | 272篇 |
出版年
2024年 | 6篇 |
2023年 | 58篇 |
2022年 | 76篇 |
2021年 | 186篇 |
2020年 | 83篇 |
2019年 | 120篇 |
2018年 | 176篇 |
2017年 | 98篇 |
2016年 | 113篇 |
2015年 | 114篇 |
2014年 | 140篇 |
2013年 | 164篇 |
2012年 | 297篇 |
2011年 | 297篇 |
2010年 | 131篇 |
2009年 | 89篇 |
2008年 | 167篇 |
2007年 | 166篇 |
2006年 | 122篇 |
2005年 | 110篇 |
2004年 | 74篇 |
2003年 | 57篇 |
2002年 | 41篇 |
2001年 | 18篇 |
2000年 | 18篇 |
1999年 | 19篇 |
1998年 | 8篇 |
1997年 | 9篇 |
1996年 | 5篇 |
1995年 | 12篇 |
1994年 | 9篇 |
1992年 | 15篇 |
1991年 | 16篇 |
1990年 | 10篇 |
1989年 | 7篇 |
1988年 | 10篇 |
1987年 | 11篇 |
1986年 | 7篇 |
1985年 | 4篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1979年 | 4篇 |
1975年 | 4篇 |
1973年 | 3篇 |
1971年 | 5篇 |
1970年 | 4篇 |
1969年 | 6篇 |
1968年 | 4篇 |
1967年 | 3篇 |
1965年 | 6篇 |
排序方式: 共有3160条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Emilie Balasse Gregory Gatouillat Dominique Patigny Marie Christine Andry Claudie Madoulet 《Vaccine》2009
Malignant melanoma causes significant health problems. The identification of tumour-associated antigens has led to novel approaches to increase T cell mediated anti-tumour immune response. Melan-A/MART-1 has been use as target antigen for several T cell based immunotherapeutic treatments. More recently, the critical role of CD4+ T cells in inducing and maintaining anti-tumour immunity has been increasingly recognized. In order to optimize tumour immunotherapy, greater efforts have been concentrated on the identification of tumour antigens presented by MHC class II molecules to CD4+ T cells. In a publication, Tiwari et al. (2004) [1] have identified by a computational approach the 15-mer amino-acid sequence 101–115 (PPAYEKLSAEQSPPP) of the Melan-A/MART-1 as a good target for a vigorous and safe immunotherapy. Therefore, we have investigated the in vivo anti-tumour activity of this peptide in a murine melanoma model. For the prophylactic treatment, 20 μg or 50 μg peptide was subcutaneously injected in mice once a week during 3 weeks before tumour induction. Treatment with 50 μg peptide significantly affected tumour development. Thus, our preliminary data demonstrate potential in vivo prophylactic activity of the 101–115 peptide-based vaccine to control melanoma growth. 相似文献
5.
Although information regarding attitudes and characteristics of human blood donors has been researched, little is known about the motivations and demographic and personality characteristics of women who choose to donate their breast milk. Eight milk banks in France participated in a study examining donor characteristics, providing data on 103 women. The results showed that the donors were women of average childbearing age with strong support at home. Almost half did not work outside of the home, compared to the national average of 80% of women in this age group; similarly, a large number (currently working or not) were from the health and social services fields. Reasons for donation were largely altruistic, and a general optimistic attitude prevailed within the participants. The results of this study provide useful information for the recruitment of potential donors as well as information on how to facilitate and provide optimal service through milk donation. 相似文献
6.
James N. Gladstone MD Kevin E. Wilk PT James R. Andrews MD 《Operative Techniques in Sports Medicine》1997,5(2):78-87
Nonoperative treatment is generally the choice for Type I and II acromioclavicular (AC) joint injuries. The situation issomewhat more controversial when Type III AC dislocations are considered, particularly with respect to athletes and heavy laborers. A number of recent studies have supported conservative treatment in these groups. There is general consensus as to the need for surgical intervention for Type IV, V, and VI AC injuries. Integral to any form of management, nonoperative or operative, is a rehabilitation program that addresses range of motion, strength, and neuromuscular control. We describe our program, which is divided into four phases: (1) Pain control and immediate protected range of motion and isometric exercises; (2) strengthening exercises using isotonic contractions and proprioceptive neuromuscular facilitation (PNF) exercises; (3) Unrestricted functional participation with the goal of increasing strength, power, endurance, and neuromuscular control; and (4) return to activity with sport specific functional drills. An athlete is ready to return to competitive sports once the following criteria are met: full range of motion (ROM), no pain or tenderness, satisfactory clinical exam, and demonstration of adequate strength on isokinetic testing. The unique considerations in a throwing athlete with an AC injury are also addressed. The primary goal of the nonoperative treatment protocol is to return the athlete to full activities as quickly and as safely as possible. 相似文献
7.
A new syndrome with features of the Smith-Lemli-Opitz and Meckel-Gruber syndromes in a sibship with cerebellar defects 总被引:3,自引:0,他引:3
A C Casamassima P Mamunes I M Gladstone S Solomon C Moncure 《American journal of medical genetics》1987,26(2):321-336
The Smith-Lemli-Opitz syndrome (SLOS) and the Meckel syndrome (MS) have been regarded as separate autosomal recessive entities. Recently, overlap of these two syndromes has been discussed. A sibship containing a probable new syndrome with features reminiscent of the SLOS and the MS is presented. The literature is reviewed with regard to the frequency of various malformations in these syndromes. Clinical manifestations and cerebellar abnormalities in these sibs are similar to those described in the Joubert syndrome (JS). These three cases may represent a new syndrome with features in common with SLOS, MS, and JS resulting from the same mutant gene, which exhibits considerable pleiotropy. 相似文献
8.
Jean E Dumas Jenelle Nissley Alicia Nordstrom Emilie Phillips Smith Ronald J Prinz Douglas W Levine 《Journal of clinical child and adolescent psychology》2005,34(1):93-104
We conducted 2 studies to (a) establish the usefulness of the construct of home chaos, (b) investigate its correlates, and (c) determine the validity of the Confusion, Hubbub, and Order Scale (CHAOS) used to measure the construct in each study. Study 1 relied on a sample of European American preschoolers and their mothers and Study 2 on a sample of African American school-age children and their caregivers. Home chaos was associated with less effective parental discipline; elevated behavior problems, limited attentional focusing, and reduced ability to understand and respond to social cues in children; and reduced accuracy and efficiency in a cooperative parent-child interactional task, after controlling for potential confounds. It is concluded that (a) home chaos is not a proxy for adverse social or psychological circumstances but a useful construct in its own right; (b) home chaos is associated with multiple detrimental correlates in parents and children; and (c) the CHAOS scale provides an adequate and economical measure of home confusion and disorganization that should prove useful in clinical research with diverse populations. 相似文献
9.
Juan Manuel Leyva-Castillo Mrinmoy Das Emilie Artru Juhan Yoon Claire Galand Raif S. Geha 《The Journal of allergy and clinical immunology》2021,147(6):2305-2315.e3
- Download : Download high-res image (242KB)
- Download : Download full-size image
10.
Reading Julian P.; Huffman John L.; Wu Joy C.; Palmer Frances T.; Harton Gary L.; Sisson Michael E.; Keyvanfar Keyvan; Gresinger Thomas H.; Cochrane William J.; Fallon Lee A.; Menapace-Drew Gianna F.; Cummings Emilie A.; Jones Shirley L.; Black Susan H.; Schulman Joseph D.; Levinson Gene 《Molecular human reproduction》1995,1(7):362-367
The discovery of nucleated erythrocytes in maternal circulationprovides a potential source for non-invasive prenatal diagnosis.We have evaluated the use of a three-stage procedure to determinethe number of cells that are of fetal rather than maternal origin.First, monoclonal antibodies specific for CD45 and CD14 wereused in conjunction with a magnetic (MACS) column to depleteunwanted leukocytes from maternal blood. This was followed bya positive MACS enrichment for nucleated erythrocytes, usingan anti-CD71 (transferrin receptor) monoclonal antibody. Todiscriminate between fetal nucleated erythrocytes and thoseof maternal origin, enriched fractions were simultaneously stainedwith an anti-fetal haemoglobin (HbF) antibody and hybridizedwith probes specific for X and Y chromosomes. Samples were thensubjected to blind analysis along with negative control samplesfrom non-pregnant volunteers. Using this dual analysis, we wereable to determine that less than one nucleated erythrocyte perml of maternal blood was of fetal origin. Small numbers of thesefetal cells were found in 87.5% of pregnancies, ranging from6 to 35 weeks gestational age. Comparison of HbF and X/Y probedata also suggests that the fetal cells are less suitable forfluorescence in-situ hybridization (FISH) analysis than similarpreparations from other sources. cell separation methods/fluorescence in-situ hybridization/hereditary diseases/polymerase chain reaction/pregnancy 相似文献