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排序方式: 共有663条查询结果,搜索用时 15 毫秒
1.
2.
VIM thalamic stimulation for tremor in a patient with IgM paraproteinaemic demyelinating neuropathy. 总被引:1,自引:0,他引:1
Evzen R?zicka Robert Jech Katerina Zárubová Jan Roth Dusan Urgosík 《Movement disorders》2003,18(10):1192-1195
We demonstrate the effect of deep brain stimulation of the ventral intermediate thalamic nucleus on intractable action tremor, in a 72-year-old man suffering from neuropathy associated with monoclonal gammopathy. 相似文献
3.
In a sample of 55 consecutive methadone maintenance admissions to our clinic, 42% were diagnosed with antisocial personality disorder (ASPD) using the National Institute of Mental Health Diagnostic Interview Schedule NIMH DIS. Individuals with ASPD exhibited greater risk for HIV infection as defined by more sexual contacts, needle use and equipment sharing. Data at 1 year follow-up were obtained on this group of patients. The objective was to compare the ASPD and non-ASPD groups with regards to demographics, drug abuse history, outcome and retention in treatment. There were no significant differences between the groups on any demographic or treatment outcome variables. Survival analysis indicated that there were no group differences in treatment retention. In conclusion, although there were no differences in treatment outcome between ASPD and non-ASPD groups it is possible that ASPD patients who drop out of treatment will be at higher risk for contracting and spreading HIV within the IV drug using population. These data also suggest that in this population the diagnosis of ASPD using primarily behavioral traits as measured in the NIMH-DIS-III, has little utility in predicting treatment outcome. 相似文献
4.
Rosalyn A. Griffiths Dusan Hadzi-Pavlovic Lorna Channon-Little 《European eating disorders review》1994,2(4):202-220
The study reports the pre-post findings from a controlled comparative evaluation of treatments for bulimia nervosa. These pre-post results allow comparison of the hypnobehavioural and cognitive behavioural treatments with a waiting list control group and a comparison of the immediate effects of the two modalities. One hundred and thirty subjects were screened to enter the study. Seventy-eight subjects entered the investigation after being randomly allocated to either a waiting list control group, or to hypnobehavioural or cognitive behavioural groups. The treatments were delivered individually and matched in duration (8 weeks) and the number of sessions. Pre to posttreatment outcome indicated significant differences between the control group and the two treatments in reductions in bulimic behaviours and related eating pathology. The immediate effects of both treatments were equal. There were no differences at posttreatment between the treatments in abstinence from either bingeing or purging. The treatment effects were also similar to the immediate effects obtained by longer therapeutic approaches. 相似文献
5.
Phillip A. Reece Heather S. Hill R. Malcolm Green Raymond G. Morris Barry M. Dale Dusan Kotasek Robert E. Sage 《Cancer chemotherapy and pharmacology》1988,22(4):348-352
Summary The renal clearance of melphalan and the fraction unbound in plasma were determined after intravenous infusion of 5 mg/m2 over 5 min in nine patients with cancer to obtain information regarding the mechanism of renal handling of melphalan. Four of the patients underwent bone marrow transplantation and also received an IV dose of 220 mg/m2. Total melphalan clearance after the 5 mg/m2 dose ranged from 66.0 to 272 ml/min per m2; the percentage of the dose excreted unchanged in urine, from 2.5% to 92.8%; renal clearance, from 4.1 to 188 ml/min per m2; the fraction unbound in plasma, from 0.0598 to 0.460; and t1/2, from 39.4 to 84.3 min. Unbound melphalan clearance and renal clearance calculated from the unbound fraction in plasma for each patient ranged from 441 to 3356 ml/min per m2 and 15 to 961 ml/min per m2 respectively and were not related to serum albumin, serum creatinine or creatinine clearance. The percentage of the dose exctreted and melphalan renal clearance were not related to urine flow. There was evidence of active secretion of melphalan in the kidney an possible reabsorption. There were no significant paired differences in melphalan disposition between the high- and low-dose studies. Highly variable renal clearance involving active secretion may contribute in part to large interpatient differences in the total plasma clearance of melphalan in patients with cancer.This study was supported by a grant from The Queen Elizabeth Hospital Research Foundation 相似文献
6.
Perić A Sotirović J Baletić N Kozomara R Bijelić D Rasić D 《Vojnosanitetski pregled. Military-medical and pharmaceutical review》2008,65(3):255-258
BACKGROUND: Concha bullosa (CB) is pneumatization of the middle turbinate and one of the most common anatomic variation of the sinonasal region. It is found in about 25% of the population. Middle meatus obstructive syndrome (MMOS) is, usually connected with CB. The main symptoms of this syndrome are headaches, impaired nasal breathing and hyposmia. Headache is the most common symptom and it may occur due to contact between a CB and other structures of the nasal cavity. CASE REPORT: We presented a case of 32 year-old-woman with headaches, located in the orbital and the left frontal region. The headaches were intermittent and corresponding to the nasal cycle. After neurologic and allergic examination, endoscopic nasal examination demonstrated a septal deviation to the right side and a large middle turbinate in the left side of the nasal cavity. Coronal computerized tomography (CT) of the paranasal sinuses demonstrated the septal deformation and pneumatization of the left middle turbinate. Diagnosis was confirmed by lidocaine test. In the functional endoscopic surgery (FESS), the lateral lamela of the anterior CB was removed. At the same time, the septoplasty was done. At the control examination, the patient was without symptoms. CONCLUSION: Although CB is the common anatomic variation of the nasal cavity, MMOS is rare. Headache (rhinogenic origin) is the most important symptom. Surgical treatment is the lateral resection of the CB in the FESS technique and the septoplasty. 相似文献
7.
Davidovic LB Kostic DM Jakovljevic NS Kuzmanovic IL Simic TM 《World journal of surgery》2003,27(5):545-550
Abstract
The surgical treatment of 30 cases of vascular thoracic outlet syndrome (TOS) in 25 patients is presented. Patients included
17 women and 8 men with average age of 26.1 years. The causes of compression were cervical rib (n = 16), soft tissue anomalies (n = 12), and scar tissue after clavicle fracture (n = 2). Ten subclavian artery aneurysms containing intraluminal thrombus as well as one subclavian artery occlusion were found.
All such cases had multiple distal arterial embolization. Presenting features of cases with arterial TOS included: hand ischemia
(n = 11), transient ischemic attack (TIA) (n = 1), and claudication or vasomotor phenomena during the arm hyperabduction (n = 11). Two patients with venous TOS developed hand edema during arm hyperabduction, and five other patients had axillary-subclavian
venous thrombosis. In all cases decompressive procedures using a combined supraclavicular and infraclavicular approach were
performed. Decompression was achieved by cervical rib excision (n = 12), combined cervical and first rib excision (n = 4), and first rib excision (n = 14). In all cases division of all soft tissue elements was also accomplished. Associated vascular procedures included resection
and replacement of 10 subclavian artery aneurysms, one subclavian-axillary and one axillary-brachial bypass, as well as nine
brachial embolectomies. All five cases with axillary-subclavian vein thrombosis before decompression were treated with anticoagulant
therapy. The mean follow-up period was 3 years and 2 months (range 1 to 6 years). Two pleural entry injuries and two transient
brachial plexus injuries were noted. All reconstructed arteries were patent during the follow-up period. Complete resolution
of symptoms with a return to full activity was noticed in all cases with arterial TOS and in two cases with venous TOS without
axillary-subclavian vein thrombosis. In cases with axillary-subclavian vein thrombosis relief of symptoms was mild, and there
were limitations on daily activity. Vascular TOS is seen less frequently than the neurogenic form; however, in most cases
it requires surgical treatment. We prefer a combined supraclavicular and infraclavicular approach because it offers complete
exposure of the subclavian artery, cervical and first ribs, and all soft tissue anomalies.
Electronic Publication 相似文献
8.
Roman Liscak Vilibald Vladyka Dusan Urgosik Gabriela Simonova Josef Vymazal 《Acta neurochirurgica》2009,151(4):317-324
Purpose When gamma knife radiosurgery (GKS) does not achieve control of the growth of a tumour, the need to repeat treatment is considered.
The results and risks of repeat treatment of patients with a vestibular schwannoma were reviewed to assess its efficacy and
safety.
Methods Between 1992 and 2001, we treated 351 patients with a vestibular schwannoma by GKS, control of the growth of the tumour was
not achieved in 32. 26 patients underwntrepeat GKS and five patients had an open microsurgical operation and one stereotactic
aspiration of a tumour cyst.
Results Twenty-four of 26 patients were followed up after the repeat GKS for a median of 43 months. 15 tumours became smaller, seven
remained unchanged and two enlarged. After the second GKS one patient’s hearing deteriorated, one developed facial weakness
and three facial spasms. One patient required insertion of ventriculo-peritoneal drainage. An operation to radically resect
the tumour was performed in five patients after the first GKS and for a subtotal removal in one after repeated GKS.
Conclusions In the small proportion of patients (9%) in whom initial GKS does not control the growth of a vestibular schwannoma, most
can be controlled by further GKS with a very low risk of a complications. 相似文献
9.
Renata Mojzikova Pavla Koralkova Dusan Holub Zuzana Zidova Dagmar Pospisilova Jaroslav Cermak Zuzana Striezencova Laluhova Karel Indrak Martina Sukova Martina Partschova Jana Kucerova Monika Horvathova Vladimir Divoky 《British journal of haematology》2014,165(4):556-563
Pyruvate kinase (PK) deficiency is an iron‐loading anaemia characterized by chronic haemolysis, ineffective erythropoiesis and a requirement for blood transfusion in most cases. We studied 11 patients from 10 unrelated families and found nine different disease‐causing PKLR mutations. Two of these mutations ‐ the point mutation c.878A>T (p.Asp293Val) and the frameshift deletion c.1553delG (p.(Arg518Leufs*12)) ‐ have not been previously described in the literature. This frameshift deletion was associated with an unusually severe phenotype involving neonatal hyperferritinaemia that is not typical of PK deficiency. No disease‐causing mutations in genes associated with haemochromatosis could be found. Inappropriately low levels of hepcidin with respect to iron loading were detected in all PK‐deficient patients with increased ferritin, confirming the predominant effect of accelerated erythropoiesis on hepcidin production. Although the levels of a putative hepcidin suppressor, growth differentiation factor‐15, were increased in PK‐deficient patients, no negative correlation with hepcidin was found. This result indicates the existence of another as‐yet unidentified erythroid regulator of hepcidin synthesis in PK deficiency. 相似文献
10.
Ljubomir M. Petrovic Dusan M. Zorica Igor Lj Stojanac Veljko S. Krstonosic Miroslav S. Hadnadjev Teodor M. Atanackovic 《Dental materials》2013