全文获取类型
收费全文 | 1468篇 |
免费 | 95篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 70篇 |
儿科学 | 37篇 |
妇产科学 | 40篇 |
基础医学 | 176篇 |
口腔科学 | 5篇 |
临床医学 | 128篇 |
内科学 | 370篇 |
皮肤病学 | 7篇 |
神经病学 | 119篇 |
特种医学 | 74篇 |
外科学 | 152篇 |
综合类 | 4篇 |
预防医学 | 251篇 |
眼科学 | 17篇 |
药学 | 61篇 |
肿瘤学 | 63篇 |
出版年
2022年 | 7篇 |
2021年 | 23篇 |
2020年 | 8篇 |
2019年 | 27篇 |
2018年 | 37篇 |
2017年 | 21篇 |
2016年 | 35篇 |
2015年 | 30篇 |
2014年 | 59篇 |
2013年 | 76篇 |
2012年 | 79篇 |
2011年 | 102篇 |
2010年 | 56篇 |
2009年 | 67篇 |
2008年 | 72篇 |
2007年 | 90篇 |
2006年 | 102篇 |
2005年 | 97篇 |
2004年 | 94篇 |
2003年 | 78篇 |
2002年 | 77篇 |
2001年 | 57篇 |
2000年 | 37篇 |
1999年 | 30篇 |
1998年 | 14篇 |
1997年 | 11篇 |
1994年 | 5篇 |
1993年 | 9篇 |
1992年 | 12篇 |
1991年 | 12篇 |
1990年 | 5篇 |
1989年 | 16篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 7篇 |
1982年 | 6篇 |
1978年 | 5篇 |
1977年 | 8篇 |
1976年 | 7篇 |
1975年 | 7篇 |
1974年 | 7篇 |
1973年 | 4篇 |
1972年 | 6篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1968年 | 4篇 |
1963年 | 3篇 |
排序方式: 共有1574条查询结果,搜索用时 15 毫秒
1.
2.
Dorit Gräbsch 《MedR Medizinrecht》2006,24(1):VI-VIII
Ohne Zusammenfassung 相似文献
3.
Dorit Gräbsch 《MedR Medizinrecht》2006,24(4):VI-VIII
Ohne Zusammenfassung 相似文献
4.
Using complexity theory to build interventions that improve health care delivery in primary care 下载免费PDF全文
Litaker David Tomolo Anne Liberatore Vincenzo Stange Kurt C. Aron David 《Journal of general internal medicine》2006,21(2):S30-S34
Previous observational research confirms abundant variation in primary care practice. While variation is sometimes viewed as problematic, its presence may also be highly informative in uncovering ways to enhance health care delivery when it represents unique adaptations to the values and needs of people within the practice and interactions with the local community and health care system. We describe a theoretical perspective for use in developing interventions to improve care that acknowledges the uniqueness of primary care practices and encourages flexibility in the form of intervention implementation, while maintaining fidelity to its essential functions. 相似文献
5.
Dorit Gräbsch 《MedR Medizinrecht》2007,25(6):VI-VIII
Ohne Zusammenfassung 相似文献
6.
7.
8.
Dorit Naot Usha Bava Brya Matthews Karen E Callon Gregory D Gamble Michael Black Sarah Song Rocco P Pitto Tim Cundy Jill Cornish Ian R Reid 《Journal of bone and mineral research》2007,22(2):298-309
Paget's disease is a focal condition of bone. To study changes in cells within pagetic lesions, we cultured osteoblasts and stromal cells from 22 patients and compared gene expression in these cells to cells from healthy bone. We identified several differentially regulated genes, and we suggest that these changes could lead to the formation of the lesions. INTRODUCTION: Paget's disease is a focal condition of bone of unknown cause. Although it is regarded as primarily an osteoclast disorder, the tight coupling of the activity of osteoclasts and osteoblasts suggests that the osteoblast could play a key role in its pathogenesis. The aim of the study was to identify possible changes in pagetic osteoblasts and stromal cells that might contribute to the development of pagetic lesions. MATERIALS AND METHODS: Candidate genes were identified based on known bone cell regulators, supplemented with microarray analysis. Gene expression was determined by real-time PCR in primary cultures of osteoblasts and bone marrow stromal cells from pagetic patients and control subjects. Concentrations of secreted proteins were determined by ELISA. RESULTS: Dickkopf1 mRNA and protein levels were increased in both pagetic osteoblast and stromal cell cultures, and interleukin (IL)-1 and IL-6 were overexpressed in pagetic osteoblasts. These changes parallel recent findings in myeloma bone disease, which shares some clinical similarities with Paget's disease. Alkaline phosphatase was overexpressed, and bone sialoprotein and osteocalcin were underexpressed in pagetic osteoblasts, consistent with their circulating levels in pagetic patients. It is hypothesized that overexpression of Dickkopf1, IL-1, and IL-6 would result in stimulation of osteoclast proliferation and inhibition of osteoblast growth, leading to the development of the characteristic lytic bone lesions. By stimulating osteoblast differentiation, Dickkopf1 and IL-6 may also promote mineralization, leading to the conversion of lytic lesions to sclerotic. CONCLUSIONS: These findings suggest that dysregulated gene expression in pagetic osteoblasts could cause the changes in bone cell number and function characteristic of Paget's disease. 相似文献
9.
Assessorin Dorit Gräbsch 《MedR Medizinrecht》2007,25(8):VI-VIII
Ohne Zusammenfassung 相似文献
10.
G Stange 《Laryngo- rhino- otologie》1989,68(12):653-656
Infections of the middle and external ear caused by the problem-micro-organism Pseudomonas aeruginosa can be cured by local therapy with Ciprofloxacin and Tutofusin very quickly and without any complications. Drum ruptures caused by ear secretions close up again spontaneously. Tympanon tubes can be left in situ. Function disturbances of the middle and internal ear clear up and the functions return to normal. 相似文献