全文获取类型
收费全文 | 2019篇 |
免费 | 414篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 48篇 |
妇产科学 | 113篇 |
基础医学 | 186篇 |
口腔科学 | 30篇 |
临床医学 | 758篇 |
内科学 | 421篇 |
皮肤病学 | 55篇 |
神经病学 | 95篇 |
特种医学 | 68篇 |
外科学 | 157篇 |
综合类 | 45篇 |
一般理论 | 2篇 |
预防医学 | 120篇 |
眼科学 | 19篇 |
药学 | 214篇 |
中国医学 | 18篇 |
肿瘤学 | 88篇 |
出版年
2022年 | 23篇 |
2021年 | 41篇 |
2020年 | 19篇 |
2019年 | 30篇 |
2018年 | 102篇 |
2017年 | 113篇 |
2016年 | 142篇 |
2015年 | 130篇 |
2014年 | 125篇 |
2013年 | 175篇 |
2012年 | 129篇 |
2011年 | 122篇 |
2010年 | 113篇 |
2009年 | 120篇 |
2008年 | 120篇 |
2007年 | 117篇 |
2006年 | 94篇 |
2005年 | 67篇 |
2004年 | 85篇 |
2003年 | 50篇 |
2002年 | 33篇 |
2001年 | 28篇 |
2000年 | 30篇 |
1999年 | 42篇 |
1998年 | 27篇 |
1997年 | 21篇 |
1996年 | 21篇 |
1995年 | 14篇 |
1994年 | 13篇 |
1993年 | 10篇 |
1992年 | 19篇 |
1991年 | 31篇 |
1990年 | 25篇 |
1989年 | 22篇 |
1988年 | 19篇 |
1987年 | 11篇 |
1986年 | 12篇 |
1985年 | 22篇 |
1984年 | 9篇 |
1983年 | 7篇 |
1982年 | 10篇 |
1981年 | 10篇 |
1979年 | 11篇 |
1977年 | 6篇 |
1975年 | 7篇 |
1974年 | 7篇 |
1972年 | 5篇 |
1971年 | 9篇 |
1969年 | 13篇 |
1967年 | 5篇 |
排序方式: 共有2447条查询结果,搜索用时 15 毫秒
1.
2.
Rajesh Verma Puneet Kumar Dixit Rakesh Lalla Babita Singh 《Annals of Indian Academy of Neurology》2015,18(2):246-248
Mirror movements are simultaneous, involuntary, identical movements occurring during contralateral voluntary movements. These movements are considered as soft neurologic signs seen uncommonly in clinical practice. The mirror movements are described in various neurological disorders which include parkinsonism, cranio veretebral junction anamolies, and hemiplegic cerebral palsy. These movements are intriguing and can pose significant disability. However, no such observation regarding mirror movements in progressive hemifacial atrophy have been reported previously. We are reporting a teenage girl suffering from progressive hemifacial atrophy and epilepsy with demonstrable mirror movements in hand. 相似文献
3.
4.
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells 总被引:65,自引:10,他引:55
PADGEM protein (PADGEM), also known as GMP140, is a platelet alpha- granule membrane protein that is translocated to the external membrane after platelet activation. Although the biosynthesis of this protein was originally thought to be confined to megakaryocytes, the synthesis of PADGEM in endothelial cells was recently demonstrated (McEver et al: Blood 70:1974a, 1987). We now describe the subcellular localization of this protein in endothelial cells. Immunofluorescence staining of permeabilized human umbilical vein endothelial cells with KC4, a well characterized monoclonal antibody to PADGEM, showed positively stained elongated structures similar in distribution and shape to Weibel-Palade bodies. Their identity as Weibel-Palade bodies was confirmed by double label immunofluorescence using KC4 and a polyclonal antiserum to von Willebrand factor (vWf), a protein known to be specifically stored in these organelles. All Weibel-Palade bodies were found to contain PADGEM. In contrast to strong perinuclear staining produced with anti- vWf antibodies, no significant perinuclear staining was obtained with KC4, indicating that relatively little PADGEM is present in the endoplasmic reticulum and in the Golgi apparatus. In endothelial cells treated with secretagogues that stimulate vWf release the elongated structures positive for PADGEM disappeared, further identifying these structures as Weibel-Palade bodies. This observation extends the parallels between Weibel-Palade bodies and alpha-granules and suggests a possible functional association between vWf and PADGEM. 相似文献
5.
This column contains the presidential address presented during the Third Annual Meeting of the American Association of Heart Failure Nurses on June 28, 2007, in San Diego, California, titled "Building the Foundation of Excellence in Heart Failure Nursing." 相似文献
6.
7.
Validity of the 'Ten Questions' for screening serious childhood disability: results from urban Bangladesh 总被引:6,自引:0,他引:6
S S Zaman N Z Khan S Islam S Banu S Dixit P Shrout M Durkin 《International journal of epidemiology》1990,19(3):613-620
A survey of 2576 children aged two to nine years was carried out in Dhaka, Bangladesh, as part of a collaborative study to test the validity of a questionnaire (the Ten Questions) for screening severe childhood disabilities in community settings. Approximately 7% of the children were positive on the screen and this rate was slightly higher in boys than girls. The sensitivity, specificity and negative predictive value of the Ten Questions were perfect or nearly perfect for severe and moderate (serious) disabilities. The positive predictive value was only 22% for serious disabilities, but 70% of children classified as false positives were found to have mild disabilities or other conditions (such as ear infections) for which early detection and treatment could be beneficial. No major age or gender differences in the validity of the questionnaire were apparent, but this finding needs additional study and confirmation with studies based on larger samples. In general, the results indicate that the Ten Questions is a valid tool for screening serious disabilities in children and can potentially improve the efficiency of health services by reducing the number of children requiring attention from professionals. Future studies using the Ten Questions should foster greater attention to the dimensions of childhood disability as a public health problem in the less developed world. 相似文献
8.
Background : It is well known that reoperation for recurrent coronary artery disease is more difficult than primary coronary artery bypass grafting. However, it is possible to reduce the morbidity and mortality of reoperation to the same level as the initial procedure with careful surgical technique. Methods : A retrospective study of the first 200 patients who underwent redo coronary bypass grafting was undertaken. Results : In the first 200 cases of redo coronary bypass grafting at St George Hospital, Sydney (August 1986–January 1995), there were five in-hospital deaths (2.5%). There was one case of sternal infection (0.5%), which required surgical debridement, three cases of stroke (1.5%), one case of postoperative bleeding (0.5%), which required a return to theatre and six cases (3%) required mechanical ventilation for more than 24h. The need for major postoperative support (such as intra-aortic balloon pumping/adrenaline infusion) was significantly affected by the degree of urgency and the degree of pre-operative ventricular impairment. Conclusions : The mortality rate of redo coronary artery bypass grafting in this series is similar to that of primary surgery described in other reports. 相似文献
9.
An ankylosed tooth can be suitable for obtaining orthodontic anchorage. However, if such a tooth lacks adequate clinical crown height, the anchorage will not be effective. In those situations surgical luxation or restorative crown augmentation is suggested. This case report is about the restorative treatment of an ankylosed, infraoccluded tooth to enhance the anchorage for forced orthodontic eruption of impacted maxillary canines. A crown augmentation in the form of a modified bilayered (sandwich) restoration using GIC, Composite resin and Silver amalgam on left maxillary first molar (26) was successful in sustaining the anchorage for forced eruption and alignment of impacted canines. 相似文献
10.
Jaishankar Raman Anand Dixit Gil Bolotin Valluvan Jeevanandam 《European journal of cardio-thoracic surgery》2006,30(2):347-352
BACKGROUND: Complex ventricular reconstruction (CVR) is now being employed increasingly thanks to the pioneering work of Dor. However, little is known about the failure mode of CVR. We present experience from three centres with CVR and an analysis of the failure modes. METHODS: Between January 1997 and February 2005, 284 patients underwent CVR in three centres in Australia and USA. All of the procedures were performed as adjuncts to coronary artery surgery and/or valvular surgery. Patients were followed-up clinically and/or echocardiographically. Failure modes were classified as fatal or non-fatal. Non-fatal failure mode (NFM) was defined as either persistent heart failure, recurrence of LV scar, need for ventricular assistance, persistent ventricular arrhythmia, or a combination. RESULTS: Operative mortality rate (OMR) was 8% (23 deaths). This fatal failure mode was most related to urgency of surgery and cardiogenic shock in 15 patients (5.3% of OMR), stroke in 5 patients (1.8%) or postoperative bi-ventricular failure (1%). Non-fatal failure modes accounted for morbidity in 26 patients (9%). This was predominantly due to persistent septal dyskinesis in 7 patients (2.46%), persistent mitral regurgitation in 5 (1.8%), postoperative ventricular tachycardia in 4 (1.4%), sub-optimal myocardial protection in 4 (1.4%) use of a large, stiff patch in 4 (1.4%). One hundred and ninety-nine of the surviving 261 patients (76%) were in NYHA Class I. CONCLUSIONS: Complex ventricular reconstruction is a robust technique that has lasting benefit. Failure modes have been identified and could be minimized by appropriate patient and procedure selection. 相似文献