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排序方式: 共有388条查询结果,搜索用时 15 毫秒
1.
Cheng Zhang Peter Gehlbach Celine Gongora Marisol Cano Robert Fariss Stacey Hose Avindra Nath William R Green Morton F Goldberg J Samuel Zigler Debasish Sinha 《Developmental dynamics》2005,234(1):36-47
We demonstrate that expression of beta- and gamma-crystallins is associated with intraocular vessels during normal vascular development of the eye and also in the Nuc1 rat, a mutant in which the hyaloid vascular system fails to regress normally. Real-Time RT PCR, Western blot and metabolic labeling studies indicate an increased expression of beta- and gamma-crystallins in Nuc1 retina. The increased expression of crystallins was localized to the astrocytes surrounding the intraocular vessels. A similar pattern of crystallin expression was also observed in the retinal vessels during normal development. Cultured human astrocytes exposed to 3-nitropropionic acid, an established model of neuronal hypoxia, increased VEGF expression, as expected, but also increased expression of crystallins. Our data suggest that crystallins may function together with VEGF during vascular remodeling. Interestingly, in human PFV (persistent fetal vasculature) disease, where the hyaloid vasculature abnormally persists after birth, we show that astrocytes express both VEGF and crystallins. 相似文献
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Jyoti Gupta Surendra K Mattoo Debasish Basu Siddharth Sarkar 《International journal of mental health》2014,43(2):81-94
The study aimed to ascertain the psychiatric morbidity in wives of substance dependent men and to assess social support and coping as its correlates. It was carried out at the Drug De-addiction and Treatment Centre of Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh. Two groups of substance dependent men (alcohol and opioid) and their wives were recruited (n = 50 in each group). The subjects were assessed for relevant socio-demographic and clinical variables, dependence severity measures, psychiatric morbidity (GHQ 12 and MINI), coping, and social support. Patients and spouses in the opioid dependent group were of younger age and had a lesser duration of marriage than those of alcohol dependent group. In both groups, more than 70 percent of the spouses had scores above the cutoff in GHQ-12. The psychiatric diagnosis was present in 16 percent and 20 percent of the wives in alcohol and opioid dependence groups, respectively, depression and dysthymia being the commonly encountered diagnoses. Social support was comparable across both groups. The most common coping mechanisms utilized were those of denial and internalization. On multivariate logistic regression, GHQ-12 scores were the predictors of MINI diagnosis. Psychological morbidity is common in wives of patients with substance use disorders. Attention to the mental health issues can relieve the distress in this vulnerable population. 相似文献
4.
The characterization of vegetation dynamics over South Asia (SA) has been primarily conducted using satellite time series of Advanced Very High Resolution Radiometer (AVHRR) Normalized Difference Vegetation Index (NDVI). However, various vegetation indices may show diverse trend patterns over the same area. This study analysed the consistency of the vegetation spatiotemporal trends from AVHRR version 3 NDVI (NDVI3g) with the Moderate Resolution Imaging Spectroradiometer (MODIS) NDVI and Enhanced Vegetation Index (EVI) over SA during various seasons, assuming that MODIS products are of higher quality. Results showed that the spatiotemporal vegetation trends derived from the NDVI3g were analogous to both MODIS NDVI and EVI indicating greening over semi-arid regions where croplands dominate and browning over tropical/subtropical forest areas. Correlations among them were better during winter monsoon. Discrepancies occurred in tropical/subtropical densely vegetated (humid) and complex topographic areas specifically during summer monsoon (SM). This study improved the understanding of the heterogeneous vegetation trends over the vast complicated terrain of SA. It was revealed that NDVI3g is reliable to quantify vegetation trends over SA, however, calibration errors still could introduce biases during SM season. 相似文献
5.
Rituparna Maiti Vikas Bhatia Biswa Mohan Padhy Debasish Hota 《Indian Journal of Community Medicine》2015,40(4):223-232
The concept of defining essential medicines and establishing a list of them was aimed to improve the availability of affordable medicines for the world''s poor. Access to essential medicines is a major determinant of health outcomes. Several countries have made substantial progress towards increasing access to essential medicines, but access to essential medicines in developing countries like India is not adequate. In this review we have tried to present the Indian scenario in respect to availability and accessibility of essential medicines over last one decade. To enhance the credibility of Indian healthcare system, procurement and delivery systems of essential medicines have to be strengthened through government commitment, careful selection, adequate public sector financing, efficient distribution systems, control on taxes and duties, and inculcating a culture of rational use of medicines in current and future prescribers. 相似文献
6.
Brianna Lindsay Joe Oundo M. Anowar Hossain Martin Antonio Boubou Tamboura Alan W. Walker Joseph N. Paulson Julian Parkhill Richard Omore Abu S.G. Faruque Suman Kumar Das Usman N. Ikumapayi Mitchell Adeyemi Doh Sanogo Debasish Saha Samba Sow Tamer H. Farag Dilruba Nasrin Shan Li Sandra Panchalingam Myron M. Levine Karen Kotloff Laurence S. Magder Laura Hungerford Halvor Sommerfelt Mihai Pop James P. Nataro O. Colin Stine 《Emerging infectious diseases》2015,21(2):242-250
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.–induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene. 相似文献
7.
Goswami Rudra Prosad Sit Hiramanik Chatterjee Moumita Lahiri Debasish Sircar Geetabali Ghosh Parasar 《Clinical rheumatology》2021,40(3):1069-1076
Clinical Rheumatology - (1) Development and validation of a composite ultrasound score (cUSS) for the diagnosis of carpal tunnel syndrome (CTS). (2) To predict treatment response after local... 相似文献
8.
Gopal Krushna Ray Debasish Mishra Rabindra Kumar Jena Smita Mahapatra Sabita Palai Ansuman Abhishek Parida 《Indian journal of hematology & blood transfusion》2021,37(1):119
Autoimmune hemolytic anaemia (AIHA) has traditionally been classified based on the temperature sensitivity of the autoagglutinins as warm (WAIHA), cold (CAIHA) and mixed type. Autoagglutinin may be of IgG or IgM type. The present prospective study was conducted to evaluate the profile of clinical picture, severity of haemolysis, treatment response of steroid. This study on patients of adult primary AIHA was conducted by taking complete history followed by detail physical examination. Laboratory investigations were performed to establish haemolytic anaemia and to assess severity of haemolysis. Immunehematological work up including blood grouping, direct antiglobulin test (DAT), IAT, antibody screening, adsorption elution was performed to diagnose type of AIHA. All cases were followed up to assess the response to prednisolone. All the data were collected and analysed by SPSS 19. Out of 62 primary AIHA cases, female were affected more than male (41:21). WAIHA is most common type (42, 67.8%) followed by mixed (20.9%) and cold AIHA (11.3%). Severity of haemolysis showed significant correlation with the DAT strength and not with type of AIHA. (P < 0.05) On oral prednisolone, 22 cases attended complete remission, while relapse, drug dependency and partial remission was achieved in 13, 9, 3 cases respectively. Severity of haemolysis in AIHA is directly related with DAT strength. WAIHA is most common type and can be managed with oral prednisolone (cr 45.2%), without red cell transfusion in most of cases. Mixed type AIHA cases were presented mostly with severe haemolysis, with minimum therapeutic response to prednisolone and maximum relapse/drug dependency. 相似文献
9.
Cardiovascular disease is common, affecting an increasing number of persons as the population ages. To combat this growing health problem, physicians use a multitude of medications in the treatment of their patients. Although pharmacologic therapy greatly enhances quality of life for a majority of patients, there is always the potential for an unfavorable reaction. For example, cardiovascular drugs can induce a vast array of adverse dermatologic responses. This article reviews the various cutaneous reaction patterns that can occur as a result of treatment with vasodilators and other antihypertensive drugs, anticoagulants and antiplatelet drugs, thrombolytic agents, and lipid-lowering agents. 相似文献
10.
Sammani Ramanayaka Meththika Vithanage Ajit Sarmah Taicheng An Ki-Hyun Kim Yong Sik Ok 《RSC advances》2019,9(59):34359
Elevated levels of potentially toxic elements (PTEs) in aqueous environments have drawn attention recently due to their presence and toxicity to living beings. There have been numerous attempts to remove PTEs from aqueous media. The potential of metal–organic frameworks (MOFs) in removing PTEs from aqueous media has been recognized due to their distinctive advantages (e.g., increased removal capability, large surface area, adjustable porosity, and recyclability). Because of the poor stability of MOFs in water, pre and post synthetic modification and functionalization of MOFs have also been developed for water treatment investigations. This review addresses the performance and mechanisms of PTE removal in various modified MOFs in detail. In order to compare the performance of MOFs, here we used partition coefficient (PC) instead of maximum adsorption capacity, which is sensitively influenced by initial loading concentrations. Therefore, the PC of each material was used to evaluate the adsorption performance of different MOFs and to compare with other sorbents. Furthermore, it discusses the scale-up issues and forthcoming pathway for the research and development needs of MOFs for effective PTE removal. This review further elucidates the main removal mechanisms of PTEs by MOFs. Commercial or domestic water treatment systems or water filters can utilize engineered MOFs to treat water by adsorptive removal. However, marketable products have yet to be investigated thoroughly due to limitations of the large-scale synthesis of MOFs.This review examines the performance of metal–organic frameworks based on partition coefficient data over the classic maximum adsorption capacities. 相似文献