全文获取类型
收费全文 | 353篇 |
免费 | 16篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 6篇 |
妇产科学 | 4篇 |
基础医学 | 64篇 |
口腔科学 | 13篇 |
临床医学 | 41篇 |
内科学 | 73篇 |
皮肤病学 | 5篇 |
神经病学 | 25篇 |
特种医学 | 19篇 |
外科学 | 39篇 |
综合类 | 9篇 |
预防医学 | 16篇 |
眼科学 | 9篇 |
药学 | 29篇 |
中国医学 | 1篇 |
肿瘤学 | 15篇 |
出版年
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 31篇 |
2020年 | 18篇 |
2019年 | 21篇 |
2018年 | 26篇 |
2017年 | 16篇 |
2016年 | 18篇 |
2015年 | 17篇 |
2014年 | 24篇 |
2013年 | 23篇 |
2012年 | 36篇 |
2011年 | 23篇 |
2010年 | 16篇 |
2009年 | 15篇 |
2008年 | 19篇 |
2007年 | 19篇 |
2006年 | 17篇 |
2005年 | 10篇 |
2004年 | 8篇 |
2002年 | 2篇 |
2001年 | 1篇 |
1993年 | 1篇 |
排序方式: 共有372条查询结果,搜索用时 62 毫秒
1.
2.
Quinazoline-2,4(1H,3H)-dione is a major class of N-fused heterocyclic with a wide range of biological functions, including anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities, and other activities, has attracted high attention in organic and medicinal chemistry. As a consequence, all chemists and pharmaceutical chemists should be familiar with the various procedures for producing quinazoline-2,4(1H,3H)-dione. The main purpose of this paper is to provide an overview of the many manufacturing methods for various biological compounds based on the quinazoline-2,4(1H,3H)-dione and 2,4-dichloroquinazoline cores. 相似文献
3.
4.
Akbari Mohammadarian Eshghyar Fatemeh Gholipour Mahdi Eslami Solat Hussen Bashdar Mahmud Taheri Mohammad Omrani Mir Davood Ghafouri-Fard Soudeh 《Metabolic brain disease》2022,37(6):2061-2066
Metabolic Brain Disease - mTOR has been shown to be involved in the regulation of immune responses and differentiation of immune cells. This protein is a candidate molecule for unraveling the... 相似文献
5.
6.
Farzaneh Hasanian-Langroudi Mohammad-Hosein Validad Gholamreza Bahari Davood Yari 《Ophthalmic genetics》2015,36(4):309-314
Background: Keratoconus is a connective tissue-related eye disease with unknown etiology that causes the loss of visual acuity. Lysyl oxidase (LOX) is an amine oxidase that catalyzes the covalent cross-link of collagens and elastin in the extracellular environment, thus determining the mechanical properties of connective tissue. The current study aimed to investigate the possible associations between two LOX polymorphisms, rs1800449 and rs2288393, and susceptibility to keratoconus.Methods: A total of 262 Iranian subjects including 112 patients with keratoconus and 150 healthy individuals as controls were recruited. Genotyping for the LOX variants was performed using allele-specific PCR.Results: A significant difference was found between two groups regarding allelic and genotyping distribution of LOX polymorphism at position rs1800449 G>A. The frequency of AA and GA?+?AA genotypes were increased in patients compared to controls (17% versus 8% and 62.5% versus 50%, respectively), showing a statistically significant difference (OR?=?2.827, 95% CI: 1.251–6.391, p?=?0.012). The A allele was associated with an increased risk for keratoconus, with the frequency of 39.9% and 29% in patients and controls, respectively (OR?=?1.614, 95% CI: 1.119–2.326, p?=?0.011). Furthermore, the haplotype analysis revealed that the rs1800449G/rs2288393C is a protective factor against keratoconus (OR?=?0.425, 95% CI?=?0.296–0.609, p?=?0.001). Conversely, the +473A/rs2288393C (OR?=?3.703, 95% CI?=?2.230–6.149, p?=?0.001) and +473G/rs2288393G (OR?=?15.48, 95% CI?=?3.805–63.03, p?=?0.001) haplotypes were identified as risk factors for keratoconus.Conclusion: Our study demonstrated that the LOX rs1800449 genotypes (AA and GA?+?AA) and allele (A) appears to confer risk for susceptibility to keratoconus. 相似文献
7.
8.
9.
Farahnaz Fahimipour Mina Mahdian Behzad Houshmand Mohammad Asnaashari Alireza Naser Sadrabadi Seid Emadadin Najafi Farashah Seid Mohsen Mousavifard Arash Khojasteh 《Lasers in medical science》2013,28(1):93-100
Low-level laser therapy (LLLT) has been used to accelerate wound healing, yet questions remain concerning its therapeutic applications. This study aimed to compare the healing efficacy of helium-neon (He-Ne) red light (laser) and gallium aluminum arsenide (Ga-Al-As) infrared lasers at two different doses on hard palate wounds. In a randomized controlled study, 75 adult male mice were divided into five groups of 15 each, after undergoing identical surgical procedures; a control group, with no laser irradiation; HD1 and HD2 groups, treated with He-Ne laser (wavelengths 632.8 nm, power 5 mW, and spot size 0.02 cm2) at doses of 4 J/cm2 and 7.5 J/cm2 respectively; and GD1 and GD2 groups, treated with Ga-Al-As laser (wavelengths 830 nm, peak power 25 mW, and spot size 0.10 cm2) at the doses of 4 J/cm2 and 7.5 J/cm2, respectively. Five animals from each group were killed on the third, seventh, and 14 days after surgery, and biopsies were made for histological analysis. On the 3rd and 7th day after the surgery, the number of polymorphonuclear cells (PMN) in HD1, HD2, GD1, and GD2 groups was significantly lower than that of the control group. On the 7th and 14th day, the fibroblasts and new blood vessels counts and collagen density fibers in HD1, HD2, GD1, and GD2 groups were also significantly higher than that of the control groups, and the fibroblast counts and collagen density fibers in HD1 and HD2 groups were higher than that of the GD1 and GD2 groups. LLLT with He-Ne laser compared to Ga-Al-As laser has a positive healing effect on hard palate gingival wounds in mice regardless of the radiation dose. 相似文献
10.