Steroidal spirooxetanes. I. Synthesis and antiandrogenic properties of some 17-spirooxetanoandrostanes

Pharmaceutical Chemistry Journal -     

Effect of anticonvulsant agents, inducers of microsomal oxidation, on the B-link of immunity and on the natural cytotoxicity of lymphoid organ cells in rats

Administration of phenobarbital, benzonal and benzobamil in a dose of 1/20 of LD50 to rats was shown to be followed by phase changes in the system of microsomal oxidation of the liver--activation in the first days after administration with the subsequent (in 1-3 months) decrease of the activity. The drugs activate the specific link of immunity directed at detoxication of the administered substances: increase the level of specific antibody-forming cells in the spleen and antibodies in the peripheral blood. Benzonal and bezobamil enhance the killing activity of cells of the thymus, phenobarbital and benzonal suppress the natural cytotoxicity of cells of the spleen and peritoneal exudate.     

Experience with the use of laboratory methods of comprehensively evaluating the state of health of newborn infants]

The authors offer new laboratory methods for comprehensive assessment of the health status of the newborns. Introduction of these methods in practical activity of clinical diagnostic laboratories of therapeutic and prophylactic institutions will promote early diagnosis of some diseases in the newborns and help comprehensively assess the neonates' adaptation potential, this being valuable for successful management of the babies.     

Intensity of in vitro incorporation of 3H-melatonin in the thyroid gland of rabbits with pineal gland hypofunction

The structure and hormonal activity of the thyroid gland and its capacity to bind ³H-melatonin were studied in young adult Chinchilla rabbits with pineal gland hypofunction induced by 2-month exposure to constant illumination. After 2 months of constant exposure to light, the experimental animals exhibited signs of the so-called “latent hypothyroidism” and more intense binding of ³H-melatonin by the thyroid gland. This fact indicated intactness of its receptor system underlying the possibility of restoring activity of the thyroid gland under conditions of melatonin replacement therapy in hypothyroidism induced by chronic melatonin insufficiency.     

A pilot screening of prevalence of atopic states and opisthorchosis and their relationship in people of Tomsk Oblast

The study was aimed to estimate the relationship between the prevalence of allergic disease and helminth invasion by the trematode Opisthorchis felineus in rural and urban populations of Tomsk Oblast (West Siberia, Russia). Two hundred and one people from Kargasok village of Tomsk Oblast and 196 from the city of Tomsk were screened for the presence of atopy and O. felineus invasion. Opisthorchosis was found in 66 participants (32.8%) from Kargasok and in 22 people (11.2%) from Tomsk. Atopic diseases were more common in the urban population than in the rural: 52.8 and 31.4%, respectively. Positive skin-prick tests were significantly higher in the urban population than in rural people: 83.2 vs 24.4%, respectively. It was found that in the city, the presence of antibodies to O. felineus negatively correlates with the atopic sensitization by skin-prick tests. However, in the village, opisthorchosis was positively associated with atopic diseases. The data obtained confirm the negative association of rural lifestyle and atopic diseases prevalence and indicate that O. felineus invasion might be a modifying factor of this relationship in Tomsk Oblast.