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1.
Karima Daghor Abbaci Nadia Ait Hamadouche Fifi Otmani Chafia Dahou Makhloufi Farida Mechid Mohamed Makrelouf Amel Otmane Nourredine Smail Malika Boucelma Fatma Zohra Aissat Salima Lefkir-Teffiani Bilel Bengana Nadia Boukheris Amar Tebaibia Baya Taharbouchet Soraya Ayoub Brahim Benziane Nadia Oumnia Chafika Haouichet Fella Hanni Nazim Laraba Djennete Hakem Nacera Benfenatki Abdelkrim Berrah 《Medicine》2022,101(32)
This study was performed to investigate the role of neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of adult onset Still disease (AOSD) and its performance to improve the sensitivity of the classifications criteria (Yamaguchi and Fautrel Classifications).We conducted a multicenter prospective nationwide case-control study in Internal medicine, Rheumatology and Infectious disease departments, to include successively patients with suspected AOSD (2 or more major criteria of Yamaguchi or Fautrel classifications). All clinical and biological features were collected in a consensual and standardized clinical assessment at baseline and during follow-up. A receiving operating characteristic (ROC) curve was used to reassess the cutoff value of NLR. After determination of the cutoff value for NLR by ROC curve, 2 composite sets (Yamaguchi classification + NLR as a major criterion and Fautrel classification + NLR as a major criterion) were performed and evaluated.One hundred sixty patients were included, 80 patients with AOSD and 60 controls with different diagnoses. Twenty patients with incomplete data were excluded. The cutoff value for NLR equals 4 (area under the curve, AUC: 0.82). The NLR was ≥ 4 in 93.7% (75/80) of AOSD patients with a sensitivity of 93.8% and specificity of 61.7%. The association of NLR as a major criterion with the classification of Yamaguchi or Fautrel improved their sensitivity, respectively for Fautrel (76.3% to 92.5%, P = .004) and Yamaguchi (78.8% to 90%, P = .05).This study validates the NLR as a good simple biomarker of AOSD with a cutoff value of 4 and high sensitivity (93.8%). The addition of NLR (NLR ≥ 4) as a major criterion to the classifications (Yamaguchi and Fautrel) improved significantly their sensitivity and accuracy. 相似文献
2.
Dardenne G Dusseau S Hamitouche C Lefèvre C Stindel E 《Clinical orthopaedics and related research》2009,467(4):901-908
The risk of dislocation after THA reportedly is minimized if the acetabular implant is oriented at 45° inclination and 15°
anteversion with respect to the anterior pelvic plane. This reference plane now is used in computer-assisted protocols. However,
this static approach may lead to postoperative instability because the dynamic variations of the pelvis influence effective
cup orientation and are not taken into account in this approach. We propose an ultrasound tool to register the preoperative
dynamics of the pelvis for THA planning during computer-assisted surgery. To assess this pelvic behavior and its consequences
on implant orientation, we tested a new 2.5-dimensional ultrasound-based approach. The pelvic flexion was registered in sitting,
standing, and supine positions in 20 subjects. The mean values were −25.2° ± 5.8° (standard deviation), 2.4° ± 5.1°, and 6.8° ± 3.5°,
respectively. The mean functional anteversion varied by 26° and the mean functional inclination by 12° depending on the pelvic
flexion. We therefore recommend including dynamic pelvic behavior to minimize dislocation risk. The notion of a safe zone
should be revisited and extended to include changes with activity.
One or more of the authors (GD) have received funding from the French National Agency of Research, Réseau National des Technologies
pour la Santé.
Each author certifies that his or her institution has approved the human protocol for this investigation and that all investigations
were conducted in conformity with ethical principles of research, and that informed consent for participation in the study
was obtained. 相似文献
3.
Samer Arezki Toumi Ryma Soufli Imene Touil-Boukoffa Chafia 《Inflammopharmacology》2022,30(5):1685-1703
Inflammopharmacology - Probiotics and their metabolites appear to be a promising approach that targets both the intestinal inflammation and dysbiosis in bowel diseases. In this context, the... 相似文献
4.
Sarah Benchabane Mourad Belkhelfa Houda Belguendouz Sourour Zidi Abdelhalim Boudjelida Pierre Youinou Chafia Touil-Boukoffa 《Inflammopharmacology》2018,26(5):1165-1174
Background
Primary Sjögren’s syndrome (pSS) represents a chronic, systemic autoimmune disorder, characterized by lymphocytic infiltration of exocrine glands, inducing compromised secretory function and tissue destruction. Increasing evidence had revealed that inflammatory mediators, such as nitric oxide (NO) and pro-inflammatory cytokines, are critical in the development and perpetuation of pSS systemic manifestations. In our current study, we aimed to investigate the ex vivo immunomodulatory effect of interferon (IFN)-β on iNOS expression, as well as on pro-inflammatory (tumor necrosis factor (TNF)-α, interleukin (IL)-6) and immunoregulatory (IL-10) cytokine production. Furthermore, we examined potential associations between the influence of IFN-β treatment on NO production, and pSS clinical and serological manifestations.Methods
In 41 pSS patients documented for their clinical and serological features, NO and cytokines levels were measured by the Griess method and enzyme-linked immunosorbent assay, respectively. Inducible nitric oxide synthase expression was analyzed by fluorescence immunostaining assay, using peripheral blood mononuclear cells (PBMCs) isolated from healthy controls and pSS patients.Results
Our results revealed a strong down-modulating effect of IFN-β in the secretion of pro-inflammatory mediators including TNF-α, IL-6, and NO production. Interestingly, IFN-β exerts an increase in IL-10 levels. The most suppressive effect exerted by IFN-β on NO production was importantly reported for patients with neurological manifestation. This immunomodulatory effect of IFN-β on NO production is highly related to the decrease of inducible nitric oxide synthase (iNOS) expression.Conclusion
Our findings highlight a consistent ex vivo inhibitory effect of IFN-β on pro-inflammatory cytokine production and NO pathway in pSS patients. Our data suggest that IFN-β could represent a potential candidate for targeting inflammation during pSS.5.
6.
Boutemine Insaf-Meriem Amri Manel Dorgham Karim Amir Zine-Charaf Benazzouz Sara Ameur Fahima Layaida Karim Yssel Hans Touil-Boukoffa Chafia 《Inflammopharmacology》2021,29(4):1225-1239
Inflammopharmacology - Pistacia lentiscus L. (PL) is a flowering plant traditionally used in the treatment of gastrointestinal disorders. The extracts of this plant are endowed with strong... 相似文献
7.
Imene Soufli Ryma Toumi Hayet Rafa Chafia Touil-Boukoffa 《World journal of gastrointestinal pharmacology and therapeutics》2016,7(3):353-360
Inflammatory bowel diseases(IBDs), including Crohn's disease and ulcerative colitis are complex disorders with undetermined etiology. Several hypotheses suggest that IBDs result from an abnormal immune response against endogenous flora and luminal antigens in genetically susceptible individuals. The dysfunction of the mucosal immune response is implicated in the pathogenesis of IBD. The balance between pro-inflammatory cytokines [tumor necrosis factor(TNF)-α, interleukin(IL)-1b, IL-8, and IL-17A], anti-inflammatory cytokines(IL-4 and IL-13), and immunoregulatory cytokines(IL-10 and transforming growth factors b) is disturbed. Moreover, evidence from animal and clinical studies demonstrate a positive correlation between an increased concentration of nitric oxide(NO) and the severity of the disease. Interestingly, proinflammatory cytokines are involved in the up-regulation of inducible oxide synthase(iN OS) expression in IBD. However, anti-inflammatory and immunoregulatory cytokines are responsible for the negative regulation of iN OS. A positive correlation between NO production and increased pro-inflammatory cytokine levels(TNF-α, IL-6, IL-17, IL-12, and interferon-γ) were reported in patients with IBD. This review focuses on the role of cytokines in intestinal inflammation and their relationship with NO in IBD. 相似文献
8.
Manel Amri Saliha Ait Aissa Houda Belguendouz Dalila Mezioug Chafia Touil-Boukoffa 《Journal of interferon & cytokine research》2007,27(9):781-787
Hydatidosis is a widely endemic helminthic disease vectored in human by the larval stage of the metacestode Echinococcus granulosus. It is characterized by the long-term coexistence of chronic infection with detectable humoral and cellular responses against the macroparasite. Previous studies demonstrated interferon-gamma (IFN-gamma) and nitric oxide (NO) production (in vivo and in vitro) during hydatidosis. In this study, we tested the hypothesis that NO production after IFN-gamma induction may constitute a host defense against E. granulosus. We also investigated the IFN-gamma effect on protoscolices (larval form of the parasite) viability in coculture with hydatid patients' peripheral blood mononuclear cells (PBMC). PBMCs from hydatic patients incubated with IFN-gamma (100 U/mL) alone are effective in the killing of protoscolices. This scolicidal activity is concomitant with elevation of nitrite levels. NO release and cytotoxic activity are inhibited by N-monomethyl-L-arginine (L-NMMA), a specific inhibitor of the NO pathway and increased by L-arginine, an NO precursor, and tetrahydrobiopterin (BH4), a nitric oxide synthase (NOS) cofactor. Our results indicate that IFN-gamma mediated iNOS induction as one of host defense mechanism against human E. granulosus infection. 相似文献
9.
Samy Slimani Abdelmalek Abbas Amina Ben Ammar Djemaa Kebaili El Hadi Ali Fadia Rahal Mohamed Choukri Khamari Ayada Baltache Imene Khider Riad Chiheub Khireddine Khelif Sabrina Akbi Salima Rahmani Chafia Dahou-Makhloufi Nadjia Brahimi-Mazouni Sabira Abtroun-Benmadi Aicha Ladjouze-Rezig 《Rheumatology international》2014,34(9):1235-1239
The aim of this study was to compare the epidemiology of rheumatoid arthritis (RA) in North Africa to that of Western countries. We have enrolled in a cross-sectional study all consecutive patients presenting with the diagnosis of RA according to the 1987 ACR criteria, and during a 5-month period, patients were included in 11 centers across northern Algeria. Demographics, clinical data, and health assessment questionnaires (HAQ) were collected for each patient. We have estimated means, standard deviations, and 95 % confidence intervals for all parameters. Of the 249 patients (213 females and 36 males) enrolled in the study, 10 (4 %) had juvenile onset of the disease. The mean age was 50.1 ± 14.5 years, and the mean duration of RA was 8.4 ± 7.8 years. In terms of comorbidities, 18.9 % of patients reported hypertension and 5.2 % had diabetes. The mean DAS28 at inclusion was 4.3 (95 % CI 4.1–4.5); 14.0 % were in remission (DAS28 ≤ 2.6). The mean HAQ score was 0.81 ± 0.82. Rheumatoid factor was positive in 78.5 % of cases, and anti-citrullinated protein/peptide antibodies, when measured, was positive in 69.0 % of cases. Seronegative patients were older and had a relatively less severe disease. For treatment, 89.7 % of patients were taking disease-modifying anti-rheumatic drugs and only 4 % were taking biologics (rituximab); 90.8 % of patients were taking glucocorticoids, and none of the patients satisfied the recommended calcium intake guidelines. RA in Algeria is more common in women. Compared to reports from Western countries, RA in Algeria appears to be less aggressive, with more dominant seronegative oligoarthritis forms. The remission rate is comparable to that of Western populations. 相似文献
10.
Determinants of improvement in quality of life of alcohol-dependent patients during an inpatient withdrawal programme 下载免费PDF全文
Pierre Lahmek Ivan Berlin Laurent Michel Chafia Berghout Nadine Meunier Henri-Jean Aubin 《International journal of medical sciences》2009,6(4):160-167
Background: To investigate the improvement in quality of life (QoL) of alcohol-dependent patients during a 3-week inpatient withdrawal programme, and to identify the sociodemographic, clinical and alcohol-related variables associated with baseline QoL on admission and with improvement of QoL during residential treatment. 相似文献