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Gagnaire Béatrice Bado-Nilles Anne Betoulle Stéphane Amara Rachid Camilleri Virginie Cavalié Isabelle Chadili Edith Delahaut Laurence Kerambrun Elodie Orjollet Daniel Palluel Olivier Sanchez Wilfried 《Ecotoxicology (London, England)》2015,24(1):215-231
Ecotoxicology - To characterize environmental risks linked to former uranium mines in the Limousin region of France, a study was conducted on fish health effects from uranium releases. Two private... 相似文献
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Antoine Le Guernic Wilfried Sanchez Anne Bado-Nilles Olivier Palluel Cyril Turies Edith Chadili Isabelle Cavalié Laurence Delahaut Christelle Adam-Guillermin Jean-Marc Porcher Alain Geffard Stéphane Betoulle Béatrice Gagnaire 《Ecotoxicology (London, England)》2016,25(6):1234-1259
Human activities have led to increased levels of various pollutants including metals in aquatic ecosystems. Increase of metallic concentrations in aquatic environments represents a potential risk to exposed organisms, including fish. The aim of this study was to characterize the environmental risk to fish health linked to a polymetallic contamination from former uranium mines in France. This contamination is characterized by metals naturally present in the areas (manganese and iron), uranium, and metals (aluminum and barium) added to precipitate uranium and its decay products. Effects from mine releases in two contaminated ponds (Pontabrier for Haute-Vienne Department and Saint-Pierre for Cantal Department) were compared to those assessed at four other ponds outside the influence of mine tailings (two reference ponds/department). In this way, 360 adult three-spined sticklebacks (Gasterosteus aculeatus) were caged for 28 days in these six ponds before biomarker analyses (immune system, antioxidant system, biometry, histology, DNA integrity, etc.). Ponds receiving uranium mine tailings presented higher concentrations of uranium, manganese and aluminum, especially for the Haute-Vienne Department. This uranium contamination could explain the higher bioaccumulation of this metal in fish caged in Pontabrier and Saint-Pierre Ponds. In the same way, many fish biomarkers (antioxidant and immune systems, acetylcholinesterase activity and biometric parameters) were impacted by this environmental exposure to mine tailings. This study shows the interest of caging and the use of a multi-biomarker approach in the study of a complex metallic contamination. 相似文献
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Vosges M Kah O Hinfray N Chadili E Le Page Y Combarnous Y Porcher JM Brion F 《Reproductive toxicology (Elmsford, N.Y.)》2012,33(2):198-204
There is growing evidence that neuroendocrine circuits controlling development and reproduction are targeted by EDCs. We have previously demonstrated that low concentrations of 17α-ethinylestradiol (EE2) disrupt the development of forebrain GnRH neurons during zebrafish development. The objectives of the present study were to determine whether the weak estrogenic compound, nonylphenol (NP), could elicit similar effects to EE2 and to what extent the estrogen receptors are involved in mediating these effects. Using immunohistochemistry, we confirmed that EE2 exposure induces an increase in the number of GnRH-ir neurons and we demonstrated that NP is able to produce similar effects in a concentration-dependent manner. The effects of both NP and EE2 were shown to be blocked by the estrogen receptors (ERs) antagonist ICI 182-780, demonstrating the involvement of functional ERs in mediating their effects. Altogether, these results highlight the need to consider neuroendocrine networks as critical endpoints in the field of endocrine disruption. 相似文献
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Le Guernic Antoine Sanchez Wilfried Palluel Olivier Bado-Nilles Anne Floriani Magali Turies Cyril Chadili Edith Vedova Claire Della Cavalié Isabelle Adam-Guillermin Christelle Porcher Jean-Marc Geffard Alain Betoulle Stéphane Gagnaire Béatrice 《Ecotoxicology (London, England)》2016,25(8):1478-1499
Ecotoxicology - To get closer to the environmental reality, ecotoxicological studies should no longer consider the evaluation of a single pollutant, but rather combination of stress and their... 相似文献
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