收费全文 | 1309489篇 |
免费 | 99593篇 |
国内免费 | 2030篇 |
耳鼻咽喉 | 18875篇 |
儿科学 | 45578篇 |
妇产科学 | 35531篇 |
基础医学 | 186211篇 |
口腔科学 | 34350篇 |
临床医学 | 113239篇 |
内科学 | 265832篇 |
皮肤病学 | 29093篇 |
神经病学 | 103026篇 |
特种医学 | 51930篇 |
外国民族医学 | 660篇 |
外科学 | 200566篇 |
综合类 | 27231篇 |
现状与发展 | 1篇 |
一般理论 | 391篇 |
预防医学 | 98479篇 |
眼科学 | 28775篇 |
药学 | 96655篇 |
2篇 | |
中国医学 | 2574篇 |
肿瘤学 | 72113篇 |
2019年 | 10021篇 |
2018年 | 14572篇 |
2017年 | 10798篇 |
2016年 | 11601篇 |
2015年 | 12943篇 |
2014年 | 17829篇 |
2013年 | 27496篇 |
2012年 | 38370篇 |
2011年 | 40739篇 |
2010年 | 24022篇 |
2009年 | 22507篇 |
2008年 | 38738篇 |
2007年 | 41397篇 |
2006年 | 41431篇 |
2005年 | 40426篇 |
2004年 | 39398篇 |
2003年 | 38214篇 |
2002年 | 37381篇 |
2001年 | 64982篇 |
2000年 | 67819篇 |
1999年 | 57074篇 |
1998年 | 15297篇 |
1997年 | 13857篇 |
1996年 | 14296篇 |
1995年 | 13531篇 |
1994年 | 12831篇 |
1993年 | 11847篇 |
1992年 | 44617篇 |
1991年 | 43521篇 |
1990年 | 42262篇 |
1989年 | 40150篇 |
1988年 | 36947篇 |
1987年 | 36268篇 |
1986年 | 33646篇 |
1985年 | 32326篇 |
1984年 | 24182篇 |
1983年 | 20313篇 |
1982年 | 11760篇 |
1981年 | 10712篇 |
1979年 | 21352篇 |
1978年 | 14843篇 |
1977年 | 12551篇 |
1976年 | 11706篇 |
1975年 | 12640篇 |
1974年 | 14671篇 |
1973年 | 14134篇 |
1972年 | 12946篇 |
1971年 | 11745篇 |
1970年 | 11057篇 |
1969年 | 10031篇 |
Background
Since recent reports have shown that (-)-Epigallocatechin-3-gallate (EGCG) could be used for treating proliferative and inflammatory disorders, we explored its use for the management of corneal chemical burns.Materials and methods
Initially, EGCG was assayed on the rabbit corneal epithelial cell line RCE1(5T5) to establish the best testing conditions, and to avoid unwanted outcomes in the experimental animals. Then, we studied its effects on cell proliferation, cell cycle progression and cell differentiation. Afterwards, we instilled EGCG in experimental grade II corneal alkali burns in mice, three times a day up to 21 days, and evaluated by slit lamp examination and histological sections of corneal epithelial, corneal endothelial and stromal edema, as well as the presence of inflammatory cells and neovascularization.Results
EGCG reduced cell growth and led to a decline in the proportion of proliferative cells in a concentration dependent manner. At 10 μM, EGCG promoted cell differentiation, an effect not related with apoptosis or cytotoxicity. When 10 μM EGCG was instilled in corneal alkali burns in mice three times a day up to 21 days, EGCG significantly reduced corneal opacity and neovascularization. The improved clinical appearance of the cornea was associated to a controlled epithelial growth; epithelial morphology was similar to that observed in normal epithelium and contrasted with the hyperproliferative, desquamating epithelium observed in control burn wounds. EGCG reduced corneal, stromal and endothelial edema, and wound inflammation.Conclusion
This work constitutes the first evidence for the use of EGCG in the acute phase of a corneal alkali burn, representing a possible novel alternative to improve patient outcomes as an add-on therapy. 相似文献Aims
To examine the influence of pre-existing psychiatric disorder on the choice of treatment in patients with gynaecological cancer.Materials and methods
The analyses were based on all patients who underwent surgical treatment for endometrial, ovarian or cervical cancer who were registered in the Danish Gynecological Cancer Database in the years 2007–2014 (3059 patients with ovarian cancer, 5100 patients with endometrial cancer and 1150 with cervical cancer). Logistic regression model and Cox regression model, adjusted for relevant confounders, were used to estimate the effect of pre-existing psychiatric disorder on the course of cancer treatment. Our outcomes were (i) presurgical oncological treatment, (ii) macroradical surgery for patients with ovarian cancer, (iii) radiation/chemotherapy within 30 days and 100 days after surgery and (iv) time from surgery to first oncological treatment.Results
In the group of patients with ovarian cancer, more patients with a psychiatric disorder received macroradical surgery versus patients without a psychiatric disorder, corresponding to an adjusted odds ratio of 1.24 (95% confidence interval 0.62–2.41) and the chance for having oncological treatment within 100 days was odds ratio = 1.26 (95% confidence interval 0.77–2.10). As for patients with endometrial cancer, all outcome estimates were close to unity. The adjusted odds ratio for oncological treatment within 30 days after surgery in patients with cervical cancer with a history of psychiatric disorder was 0.20 (95% confidence interval 0.03–1.54).Conclusions
We did not find any significant differences in the treatment of ovarian and endometrial cancer in patients with pre-existing psychiatric diagnoses. When it comes to oncological treatment, we suggest that increased attention should be paid to patients with cervical cancer having a pre-existing psychiatric diagnosis. 相似文献Methods & Procedures: Eighteen PWA and 20 healthy older adults (HOA) completed a written sentence-picture matching task involving the interpretation of prepositional phrases (PP; the chef is poking the solider with an umbrella) that were ambiguous between high (verb modifier) and low attachment (object noun modifier). Only one interpretation was possible for prime sentences, while both interpretations were possible for target sentences. In Experiment 1, the target was presented immediately after the prime (0-lag). In Experiment 2, two filler items intervened between the prime and the target (2-lag). Within each experiment, the verb was repeated for half of the prime-target pairs, while different verbs were used for the other half. Participants’ off-line picture matching choices and response times were measured.
Results: After reading a prime sentence with a particular interpretation, HOA and PWA tended to interpret an ambiguous PP in a target sentence in the same way and with faster response times. Importantly, both groups continued to show this priming effect over a lag (Experiment 2), although the effect was not as reliable in response times. However, neither group showed lexical (verb-specific) boost on priming, deviating from robust lexical boost seen in the young adults of prior studies.
Conclusions: PWA demonstrate abstract (lexically-independent) structural priming in the absence of a lexically-specific boost. Abstract priming is preserved in aphasia, effectively facilitating not only immediate but also longer-lasting structure-message mapping during sentence comprehension. 相似文献