全文获取类型
收费全文 | 549篇 |
免费 | 55篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 16篇 |
妇产科学 | 5篇 |
基础医学 | 54篇 |
口腔科学 | 7篇 |
临床医学 | 71篇 |
内科学 | 112篇 |
皮肤病学 | 8篇 |
神经病学 | 47篇 |
特种医学 | 57篇 |
外科学 | 40篇 |
综合类 | 21篇 |
一般理论 | 1篇 |
预防医学 | 105篇 |
眼科学 | 3篇 |
药学 | 41篇 |
肿瘤学 | 24篇 |
出版年
2022年 | 5篇 |
2021年 | 6篇 |
2020年 | 6篇 |
2019年 | 5篇 |
2018年 | 4篇 |
2016年 | 15篇 |
2015年 | 12篇 |
2014年 | 20篇 |
2013年 | 24篇 |
2012年 | 50篇 |
2011年 | 59篇 |
2010年 | 30篇 |
2009年 | 31篇 |
2008年 | 30篇 |
2007年 | 18篇 |
2006年 | 17篇 |
2005年 | 25篇 |
2004年 | 23篇 |
2003年 | 18篇 |
2002年 | 20篇 |
2001年 | 17篇 |
2000年 | 11篇 |
1999年 | 9篇 |
1998年 | 14篇 |
1997年 | 18篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 7篇 |
1993年 | 4篇 |
1992年 | 9篇 |
1991年 | 4篇 |
1990年 | 8篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1977年 | 6篇 |
1976年 | 8篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1967年 | 3篇 |
1956年 | 2篇 |
1943年 | 1篇 |
排序方式: 共有614条查询结果,搜索用时 15 毫秒
1.
2.
The genetic basis of polycystic ovary syndrome 总被引:11,自引:3,他引:11
Franks S; Gharani N; Waterworth D; Batty S; White D; Williamson R; McCarthy M 《Human reproduction (Oxford, England)》1997,12(12):2641-2648
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women
of reproductive age. Familial clustering of cases suggests that genetic
factors play an important part in its aetiology. A number of studies of
families with several cases of PCOS have produced results suggesting an
autosomal dominant trait. Detailed analysis of a large number of affected
families has, however, cast some doubt about the mode of inheritance. An
autosomal dominant trait remains possible but a more complex aetiology
seems more likely. The results of our recent studies support the concept of
an oligogenic disorder in which genes affecting metabolic pathways in
glucose homeostasis and steroid biosynthesis are both involved. We review
evidence for an important role for the insulin gene minisatellite in the
aetiology of anovulatory PCOS and for the gene coding for P450 cholesterol
side chain cleavage (CYP11a) in the mechanism of excessive androgen
secretion in women with polycystic ovaries. We propose that the
heterogeneity of clinical and biochemical features in PCOS can be explained
by the interaction of a small number of key genes with environmental,
particularly nutritional, factors.
相似文献
3.
Batty K 《Hospital pharmacy》1993,28(10):1029-32, 1035-6
4.
This article report on a not very well-known therapeutical procedure used among only fairly diagnosed cases based on international and Hungarian experiences. In Hungary echinococcus cyst of the liver is mostly treated surgically (the average mortality rate of liver resection is 0-6.3%). In many places the percutan puncture and drainage are contraindicated in case of echinococcus cysts. The authors assert that the percutaneous treatment of echinococcus cysts in proper technical and methodic circumstances in safe regarding the previous studies and their own data obtained of a few cases, and describe the technique and raise some question in them. Drainage treatment is very well tolerated by the patients it reduces the duration (of time) and the cost of the hospitalization. 相似文献
5.
6.
7.
8.
Abstract: We report the first case of fatal anthrax meningoencephalitis in Hong Kong over the past 60 years. A 13 year-old boy presented with right lower quadrant pain, diarrhoea and progressive headache. Lumbar puncture yielded gram positive bacilli initially thought to be Bacillus cereus, a contaminant. He was treated with ampicillin and cefotaxime, but died 3 days after hospitalization. The organism isolated from blood and cerebrospinal fluid was later identified as Bacillus anthracis. 相似文献
9.
A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma 总被引:8,自引:2,他引:8
Chen J; Giovannucci E; Hankinson SE; Ma J; Willett WC; Spiegelman D; Kelsey KT; Hunter DJ 《Carcinogenesis》1998,19(12):2129-2132
We examined the relationship between a functional polymorphism (667C--
>T, ala-->val) of the methylenetetrahydrofolate reductase gene
(MTHFR) and the risk of colorectal adenomas in the prospective Nurses'
Health Study. Among 257 incident polyp cases and 713 controls, the MTHFR
val/val polymorphism [relative risk (RR) = 1.35, 95% confidence interval
(CI) 0.84-2.17] was not significantly associated with risk of adenomas.
This lack of association was observed for both small (RR = 1.36, 95% CI
0.76-2.45) and large (RR = 1.32, 95% CI 0.66-2.66) adenomas. Furthermore,
there was no significant interaction between this polymorphism and
consumption of either folate, methionine or alcohol. We also examined the
relationship of a newly identified polymorphism (asp919gly) of the
methionine synthase gene (MS) with the risk of colorectal adenomas in the
same population. The MS gly/gly polymorphism was also not significantly
associated with risk of colorectal adenomas (RR = 0.66, 95% CI 0.26-1.70).
These results, which need to be confirmed in other studies, suggest that
the MTHFR val/val polymorphism, which has been previously inversely
associated with risk of colorectal cancer, plays a role only in a late
stage (adenoma-- >carcinoma) of colorectal tumorigenesis, and/or may
protect against malignant transformation in the subset of benign adenomas,
which may progress to malignancy.
相似文献
10.
Emilie Meaux Sylvie Roux Magali Batty 《Social cognitive and affective neuroscience》2014,9(8):1089-1098
Processing information from faces is crucial to understanding others and to adapting to social life. Many studies have investigated responses to facial emotions to provide a better understanding of the processes and the neural networks involved. Moreover, several studies have revealed abnormalities of emotional face processing and their neural correlates in affective disorders. The aim of this study was to investigate whether early visual event-related potentials (ERPs) are affected by the emotional skills of healthy adults. Unfamiliar faces expressing the six basic emotions were presented to 28 young adults while recording visual ERPs. No specific task was required during the recording. Participants also completed the Social Skills Inventory (SSI) which measures social and emotional skills. The results confirmed that early visual ERPs (P1, N170) are affected by the emotions expressed by a face and also demonstrated that N170 and P2 are correlated to the emotional skills of healthy subjects. While N170 is sensitive to the subject’s emotional sensitivity and expressivity, P2 is modulated by the ability of the subjects to control their emotions. We therefore suggest that N170 and P2 could be used as individual markers to assess strengths and weaknesses in emotional areas and could provide information for further investigations of affective disorders. 相似文献