Modification of sinusotomy]

Sinusotomy modification, developed by the authors, consists in combination of traditional subscleral surgery with posterior cyclo-retraction and the formation of an uveal pouch. This technique was used in the treatment of 28 patients (28 eyes) with primary open-angle glaucoma. Immediate hypotensive effect was achieved in all the patients (in one case surgery was paralleled by pilocarpine instillations). Twenty-four patients were examined in late periods (up to 1 year) after surgery. Ophthalmic tone normalization was achieved in 91.7% of cases (in 83.3% of cases no drug instillations were used). Vision acuity and visual field were unchanged or improved in 87.5 and 95.8% of cases, respectively. No grave complications were recorded.     

Technique of suprachoroidal space drainage in the prevention and treatment of ciliary-choroidal detachment after glaucoma surgery]

The authors recommend cross-like sclerotomy to prevent and treat a ciliary-choroidal detachment after antiglaucoma surgery. Double cross-like sclerotomy was performed in the upper half of the eye simultaneously with trabeculectomy in 30 patients with open-angle glaucoma to prevent the development of ciliary-choroidal detachment. Thirty patients subjected to similar surgery but without prophylactic sclerotomy have made up the reference group. The results evidence that double cross-like sclerotomy is an effective method for the prevention of ciliary-choroidal detachment: the incidence of this complication has dropped by 8 times (from 26.7 to 3.3%). Gross-like sclerotomy performed to treat utricular ciliary-choroidal detachment resulted in cure in all the 14 cases. The suggested sclerotomy technique is simple and low-traumatic.     

Clinical experience using streptodecase in the prehospital stage of treatment of acute myocardial infarct

The effects of prehospital streptodecase administration on clinical course, pattern of necrosis formation, myocardial contractility and blood coagulation were studied in 15 patients with acute myocardial infarction. Patients to whom thrombolytic and anticoagulant therapy was contraindicated made up the control group. A single intravenous jet injection of the total streptodecase dose (3,000,000 U) is well tolerated by patients with acute myocardial infarction without preliminary testing. Prehospital use of the drug contributes to rapid stabilization and limitation of progressive myocardial necrosis, and improves thereby the clinical course of the disease.     

Functional features of acute non-Q-wave myocardial infarction and the influence of pre-hospital treatment with propranalol, heparin and aspirin on the prognosis of the disease

193 patients with their first non-Q-wave myocardial infarction (NQMI) were examined with the aim of studying the functional features of NQMI and estimate the influence of pre-hospital treatment with propranalol (PP), heparin and aspirin. The study found that patients having NQMI with initial ST segment depression, unlike those with initial ST segment elevation, were characterized by diffuse coronary atherosclerosis, evident diastolic dysfunction and left ventricle (LV) remodeling, progressing with the course of time. Early administration of aspirin, heparin and PP reduced LV remodeling, improved diastolic function and prognosis in patients having NQMI with initial ST segment depression.     

Antiinflammatory Activity of New Aryl- and Aroylthioureas

Pharmaceutical Chemistry Journal -     

Use of nitroglycerin in acute myocardial infarct complicated by mitral insufficiency

Thirty-five patients with primary large-focal myocardial infarction (MI) were investigated, with mitral incompetence diagnosed in 19. All patients underwent clinical investigation, including electro-, phono- and echocardiography, and tetrapolar chest rheoplethysmography. Direct measurements of pulmonary arterial pressure were made in 11 patients. The investigations were carried out prior to, and at the peak of nitroglycerin action. It was shown that mitral regurgitation was associated with increased incidence and severity of heart failure during the acute stage of MI. Such patients showed low cardiac and stroke index values, a more marked overstrain of the left atrium and left ventricle, and high pulmonary arterial pressure. Intravenous administration of nitroglycerin improves intracardiac hemodynamics in acute MI, its effect being more pronounced in patients with mitral incompetence. Early and prolonged nitroglycerin treatment is indicated in cases of acute MI with mitral incompetence.