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排序方式: 共有61条查询结果,搜索用时 31 毫秒
1.
PETER D. WIMBERLEY PETER S. FREDERIKSEN JESS WITT-HANSEN STEEN G. MELBERG BENT FRIIS-HANSEN 《Acta paediatrica (Oslo, Norway : 1992)》1985,74(3):352-359
Transcutaneous-Po2 ; (tc-Po2 (tc-Pco2 ) at 44o C and transcutaneous-Pco2 ) at 38, 42, 43 and 44o C were measured with a currently available monitoring system (TCM222, Radiometer, Copenhagen) in 64 newborn infants with severe respiratory insufficiency during the first five days of life. Tc-Pco2 at all four temperatures correlated better with arterial blood-Pco2 (aB-Pco2 )> than tc-Po2 with aB-Po2. However, the sensitivity and specificity of tc-Po2 and tc-Pco2 were similar with regard to maintaining aB-Po2 , and aB-Pco2 within specified limits. Tc-Pco2 increased relatively with increasing electrode temperature by a factor which was similar to the anaerobic temperature coefficient of Po2 , in blood. The coefficient of variation of duplicate measurements was 10 % for tc-Po2 and 5 % for tc-Pco2 . Electrode drift after an average of 3 hours patient monitoring was 2%±6% (1SD) for tc-Pco2 , and -3 %±6 % for tc-Pco2 - We conclude that tc-Po2 and tc-Pco2 are a valuable supplement to arterial blood gas measurements, but the variable correlation with arterial blood gas values and the electrode drifts which may occur, mean that they cannot fully replace arterial sampling. 相似文献
2.
JØRGEN BENT ANDERSEN 《Acta paediatrica (Oslo, Norway : 1992)》1970,59(6):659-663
The changes in water and mineral metabolism in newborn infants born of mothers, who has been treated in late pregnancy with diuretics, was investigated. It was found, that all 6 parameters: the total body water, the extracellular water, the serum concentrations of sodium potassium and chloride and the osmolality all pointed in the direction that there was a slight salt and water depletion in the infants from the mothers, treated with diuretics. The biochemical observations were not clinically detectable. 相似文献
3.
CHRONIC MIGRAINOUS NEURALGIA- DIAGNOSTIC AND THERAPEUTIC ASPECTS 总被引:1,自引:0,他引:1
4.
TOVE AGNER CLAUS HAGEN BENT NYBOE ANDERSEN LASZLO HEGEDÜS 《Journal of internal medicine》1986,220(1):57-62
ABSTRACT Basal plasma concentrations of thyroxine (T4), 3,3′,5-triiodothyronine (T3), free T4 index (TF4I), free T3 index (FT3I) reverse T3, 3,3′,5-triiodothyronine (rT3), resin T3 uptake (TR3U), thyroxine-binding globulin (TBG), thyrotropin (TSH), prolactin (PRL) and growth hormone (GH) as well as thyrotropin releasing hormone (TRH) stimulated TSH, PRL and GH were investigated in 31 consecutive male patients (mean age 41 years) with chronic alcoholism. According to the histology of their liver biopsies the patients were divided into three groups: patients with normal livers, steatosis and cirrhosis. The control group consisted of 30 healthy males. The patients had abstained from alcohol for at least one week when studied, and they were on a nutritionally adequate diet. All had consumed a daily minimum of 52 g ethanol for at least 5 years. None of the patients had severe or decompensated liver disease. The patients had significantly reduced T3 and rT3 plasma levels compared to normals. Patients with cirrhosis of the liver had increased TBG and normal RT3U levels, while those without cirrhosis had increased RT3U and normal TBG levels. Plasma concentrations of basal as well as TRH-stimulated TSH and PRL were unchanged in alcoholic patients, whereas basal as well as stimulated GH levels were increased in cirrhotic alcoholics. It is concluded that alcohol per se influences T3 levels, but not the part of the hypothalamic-pituitary axis studied, and that the binding proteins are mostly determined by the degree of liver disease. 相似文献
5.
Multiple binding equilibria of two apparently insoluble ligands, palmitate and stearate, to defatted human serum albumin were studied in a 66 mM sodium phosphate buffer (pH 7.4) at 37 °C, by determination of dialytic exchange rates of ligands among identical equilibrium solutions. The experimental data were analysed by a computerised curve fitting procedure using equilibrium equations for multiple binding of ligands, containing relative binding constants, valid whether the ligands are truly insoluble or are slightly soluble and irrespective of aggregation in aqueous solution. A best-fit set of relative binding constants was found, and subsequently 30 sets of acceptable constants for each set of data in order to evaluate the variation. The data were first fitted by the relative Scatchard's equation, then by the relative, stoichiometric equation. Scatchard's equation is deduced on the presumption that cooperativity is absent while the stoichiometric equation is valid even when cooperativity is present. It was found with palmitate as well as with stearate that the two equations fitted the data equally well, and it was concluded that the observations were compatible with absence of cooperativity. The relative Scatchard binding constants were converted to relative, stoichiometric constants and it was found that the variations of the latter were slight. © Munksgaard 1997. 相似文献
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NIELS HØIBY LARS JACOBSEN BIRGIT A. JØRGENSEN ERLING LYKKEGAARD BENT WEEKE 《Acta paediatrica (Oslo, Norway : 1992)》1974,63(6):843-848
ABSTRACT, Heiby, N., Jacobsen, L., Jergensen, B. A., Lykkegaard, E. and Weeke, B. (Statens Seruminstitut, Department of Clinical Microbiology at Blegdamshospitalet, the Paediatric Clinic TG with the Paediatric Clinic of Dronning Louises Børnehospital, the Radiologic Department TX, Rigshospitalet, and the Protein Laboratory, Untversity of Copenhagen, Copenhagen, Denmark). Pseudomonas aeruginosa infection in cystic fibrosis. Acta Paediatr Scand, 63: 843, 1974.—The significance of Pseudomonas aeruginosa infection in the respiratory tract of 9 cystic fibrosis patients have been studied by means of immunoelectrophoretical analysis of patients' sera for the number of precipitins against Pseudomonas aeruginosa and the concentrations of 16 serum proteins. In addition, the clinical and radiographical status of the lungs have been evaluated using 2 scoring systems. Precipitins against Pseudomonas aeruginosa were demonstrated in all sera, the maximum number in one serum was 22. The concentrations of 12 of the serum proteins were significantly changed compared with matched control persons. Notably IgG and IgA were elevated and the "acute phase proteins" were changed, the latter suggesting active tissue damage. The concentrations of 3 of the acute phase proteins, notably haptoglobin were correlated to the number of precipitins suggesting that the respiratory tract infection in patients with many precipitins is accompanied by more tissue damage than the infection in patients with few precipitins. The results indicate no protective value of the many precipitins on the tissue of the respiratory tract. 相似文献
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9.
Spectrophotometric titration of human serum albumin indicates that ionization of the 18 tyrosine residues takes place between pH 9 and 12.7. A Hill plot indicates that protons dissociate co-operatively from tyrosine residues, in pure albumin between pH 11.0 and 11.4 with a Hill coefficient 1.7, and in the bilirubin-albumin complex between pH 11.2 and 11.7 with a Hill coefficient 1.6. With a stopped-flow technique it is shown that about seven of the tyrosines ionize fast, with rate constants well above 102 s?1, when pH is suddenly changed from near neutral to pH 11.76. Further residues ionize slowly, with rate constants around 102 s?1 or less. The N-form of albumin (pH 6) contains one more fast ionizing tyrosine than the B-form of albumin (pH 10). Binding of bilirubin or laurate to the albumin molecule (molar ratio 1:1) transforms one to three of the fast ionizing tyrosines to slowly ionizing. 相似文献
10.