全文获取类型
收费全文 | 93篇 |
免费 | 2篇 |
专业分类
儿科学 | 4篇 |
妇产科学 | 6篇 |
基础医学 | 14篇 |
临床医学 | 13篇 |
内科学 | 16篇 |
皮肤病学 | 2篇 |
神经病学 | 12篇 |
特种医学 | 4篇 |
外科学 | 5篇 |
预防医学 | 8篇 |
药学 | 5篇 |
肿瘤学 | 6篇 |
出版年
2023年 | 1篇 |
2021年 | 6篇 |
2019年 | 5篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 2篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2013年 | 3篇 |
2012年 | 8篇 |
2011年 | 11篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 8篇 |
2007年 | 3篇 |
2006年 | 4篇 |
2005年 | 3篇 |
2004年 | 4篇 |
2003年 | 1篇 |
2002年 | 2篇 |
2001年 | 5篇 |
2000年 | 3篇 |
1999年 | 1篇 |
1996年 | 1篇 |
1988年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有95条查询结果,搜索用时 15 毫秒
1.
Arbelo Nestor López-Pelayo Hugo Sagué María Madero Santiago Pinzón-Espinosa Justo Gomes-da-Costa Susana Ilzarbe Lidia Anmella Gerard Llach Cristian-Daniel Imaz María-Luisa Cámara María-Mercé Pintor Luis 《The Psychiatric quarterly》2021,92(3):1021-1033
Psychiatric Quarterly - The Coronavirus Disease 2019 (COVID-19) can affect mental health in different ways. There is little research about psychiatric complications in hospitalized patients with... 相似文献
2.
Embade N Fernández-Ramos D Varela-Rey M Beraza N Sini M Gutiérrez de Juan V Woodhoo A Martínez-López N Rodríguez-Iruretagoyena B Bustamante FJ de la Hoz AB Carracedo A Xirodimas DP Rodríguez MS Lu SC Mato JM Martínez-Chantar ML 《Hepatology (Baltimore, Md.)》2012,55(4):1237-1248
Hu antigen R (HuR) is a central RNA-binding protein regulating cell dedifferentiation, proliferation, and survival, which are well-established hallmarks of cancer. HuR is frequently overexpressed in tumors correlating with tumor malignancy, which is in line with a role for HuR in tumorigenesis. However, the precise mechanism leading to changes in HuR expression remains unclear. In the liver, HuR plays a crucial role in hepatocyte proliferation, differentiation, and transformation. Here, we unraveled a novel mean of regulation of HuR expression in hepatocellular carcinoma (HCC) and colon cancer. HuR levels correlate with the abundance of the oncogene, murine double minute 2 (Mdm2), in human HCC and colon cancer metastases. HuR is stabilized by Mdm2-mediated NEDDylation in at least three lysine residues, ensuring its nuclear localization and protection from degradation. Conclusion: This novel Mdm2/NEDD8/HuR regulatory framework is essential for the malignant transformation of tumor cells, which, in turn, unveils a novel signaling paradigm that is pharmacologically amenable for cancer therapy. 相似文献
3.
4.
5.
6.
7.
8.
We present the case of a 4-year-old boy with malaria who developed acute respiratory distress syndrome with severe hypoxemia refractory to mechanical ventilation and inhaled nitric oxide. Placing the patient in prone position immediately and persistently improved oxygenation: the ratio of P(aO(2)) to fraction of inspired oxygen rose from 47 to 180 mm Hg and the oxygenation index decreased from 40 to 11. The patient survived, with no respiratory sequelae. 相似文献
9.
10.
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer 总被引:6,自引:1,他引:5
Carracedo A Ma L Teruya-Feldstein J Rojo F Salmena L Alimonti A Egia A Sasaki AT Thomas G Kozma SC Papa A Nardella C Cantley LC Baselga J Pandolfi PP 《The Journal of clinical investigation》2008,118(9):3065-3074
Numerous studies have established a causal link between aberrant mammalian target of rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have therapeutic potential. In this study, we show that rapamycin and its analogs activate the MAPK pathway in human cancer, in what represents a novel mTORC1-MAPK feedback loop. We found that tumor samples from patients with biopsy-accessible solid tumors of advanced disease treated with RAD001, a rapamycin derivative, showed an administration schedule–dependent increase in activation of the MAPK pathway. RAD001 treatment also led to MAPK activation in a mouse model of prostate cancer. We further show that rapamycin-induced MAPK activation occurs in both normal cells and cancer cells lines and that this feedback loop depends on an S6K-PI3K-Ras pathway. Significantly, pharmacological inhibition of the MAPK pathway enhanced the antitumoral effect of mTORC1 inhibition by rapamycin in cancer cells in vitro and in a xenograft mouse model. Taken together, our findings identify MAPK activation as a consequence of mTORC1 inhibition and underscore the potential of a combined therapeutic approach with mTORC1 and MAPK inhibitors, currently employed as single agents in the clinic, for the treatment of human cancers. 相似文献