全文获取类型
收费全文 | 6488篇 |
免费 | 465篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 73篇 |
儿科学 | 186篇 |
妇产科学 | 103篇 |
基础医学 | 835篇 |
口腔科学 | 276篇 |
临床医学 | 704篇 |
内科学 | 1120篇 |
皮肤病学 | 192篇 |
神经病学 | 753篇 |
特种医学 | 186篇 |
外科学 | 869篇 |
综合类 | 17篇 |
一般理论 | 3篇 |
预防医学 | 451篇 |
眼科学 | 28篇 |
药学 | 704篇 |
中国医学 | 8篇 |
肿瘤学 | 449篇 |
出版年
2022年 | 45篇 |
2021年 | 108篇 |
2020年 | 102篇 |
2019年 | 114篇 |
2018年 | 175篇 |
2017年 | 116篇 |
2016年 | 144篇 |
2015年 | 132篇 |
2014年 | 206篇 |
2013年 | 292篇 |
2012年 | 371篇 |
2011年 | 359篇 |
2010年 | 209篇 |
2009年 | 208篇 |
2008年 | 316篇 |
2007年 | 349篇 |
2006年 | 351篇 |
2005年 | 287篇 |
2004年 | 284篇 |
2003年 | 294篇 |
2002年 | 255篇 |
2001年 | 178篇 |
2000年 | 167篇 |
1999年 | 182篇 |
1998年 | 80篇 |
1997年 | 76篇 |
1996年 | 54篇 |
1995年 | 64篇 |
1994年 | 58篇 |
1993年 | 54篇 |
1992年 | 130篇 |
1991年 | 109篇 |
1990年 | 86篇 |
1989年 | 91篇 |
1988年 | 112篇 |
1987年 | 75篇 |
1986年 | 80篇 |
1985年 | 84篇 |
1984年 | 53篇 |
1983年 | 42篇 |
1982年 | 49篇 |
1981年 | 32篇 |
1980年 | 29篇 |
1979年 | 51篇 |
1978年 | 34篇 |
1977年 | 31篇 |
1975年 | 41篇 |
1974年 | 28篇 |
1973年 | 35篇 |
1971年 | 26篇 |
排序方式: 共有6957条查询结果,搜索用时 0 毫秒
1.
2.
Neurofibromatosis Type 1 Diagnosed in a Child Based on Multiple Juvenile Xanthogranulomas and Juvenile Myelomonocytic Leukemia
下载免费PDF全文
![点击此处可从《Pediatric dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sune R. R. Jans M.D. Eckhard Schomerus M.D. Anette Bygum M.D. 《Pediatric dermatology》2015,32(1):e29-e32
An association between juvenile xanthogranuloma (JXG), neurofibromatosis type 1 (NF1), and juvenile myelomonocytic leukemia (JMML) has been described in the literature but has only been documented in approximately 20 cases. We diagnosed a patient with NF1 at 25 months of age, before any cutaneous stigmata of this disease had appeared, because we decided to screen for the NF1 gene mutation because of his presentation with multiple JXGs and moderate macrocephaly (2.5 standard deviations) at 9 months of age and JMML diagnosed at 20 months of age. The child is well today after treatment with chemotherapy and allogenic bone marrow transplantation. With increased awareness, patients with JXG and NF1 who develop symptoms possibly related to JMML, such as paleness, skin bleeding, cough, unexplained fever, and hepatosplenomegaly, should be further evaluated. We also emphasize that multiple JXG lesions can be an early marker of NF1. 相似文献
3.
Yoshiki Imamura Takahiro Shinozaki Akiko Okada‐Ogawa Noboru Noma Masahiro Shinoda Koichi Iwata Akihiko Wada Osamu Abe Kelun Wang Peter Svensson 《Journal of oral rehabilitation》2019,46(6):574-587
Burning mouth syndrome (BMS) is a chronic oro‐facial pain disorder of unknown cause. It is more common in peri‐ and post‐menopausal women, and sex hormone dysregulation is believed to be an important causative factor. Psychosocial events often trigger or exacerbate symptoms, and persons with BMS appear to be predisposed towards anxiety and depression. Atrophy of small nerve fibres in the tongue epithelium has been reported, and potential neuropathic mechanisms for BMS are now widely investigated. Historically, BMS was thought to comprise endocrinological, psychosocial and neuropathic components. Neuroprotective steroids and glial cell line–derived neurotrophic factor family ligands may have pivotal roles in the peripheral mechanisms associated with atrophy of small nerve fibres. Denervation of chorda tympani nerve fibres that innervate fungiform buds leads to alternative trigeminal innervation, which results in dysgeusia and burning pain when eating hot foods. With regard to the central mechanism of BMS, depletion of neuroprotective steroids alters the brain network–related mood and pain modulation. Peripheral mechanistic studies support the use of topical clonazepam and capsaicin for the management of BMS, and some evidence supports the use of cognitive behavioural therapy. Hormone replacement therapy may address the causes of BMS, although adverse effects prevent its use as a first‐line treatment. Selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) may have important benefits, and well‐designed controlled studies are expected. Other treatment options to be investigated include brain stimulation and TSPO (translocator protein 18 kDa) ligands. 相似文献
4.
Background
A standardised suction technique has been used to sample plasma proteins in dermal interstitial fluid (IF) serially for 5 to 6 days from a suction-induced skin mini-erosion. Increased protein concentrations ascribed to inflammation have been shown from day 1 onward. In this study, we assessed the effect of two different extraction pressures on IF sample composition. 相似文献5.
6.
M. Vrethem B. Lindvall S. Kihlstrand E. Bckman T. Brismar P. Fredman K.G. Henriksson 《European journal of neurology》1996,3(2):156-159
We report improvement in muscle strength in a patient with multifocal motor neuropathy (MMN) when given high-dose intravenous immunoglobin (i.v.-Ig) treatment. The patient had asymmetrical limb weakness, atrophy and absent or weak reflexes, but no sensory disturbances. Neurography showed multiple conduction blocks in peripheral motor nerves but no sensory nerve abnormalities. Serum and anti-GM1 antibodies were not found, however, the patient had serum antibodies against the glycolipid LK1, an epitope found both in glycolipid and also in some glycoproteins in peripheral nerve myelin. Muscle strength improved 5 days after i.v.-Ig therapy, and lasted about 10 weeks. Repeated courses of treatment resulted in similar improvement. This is, to our knowledge, the first patient reported with MMN found to have antibodies against the glycolipid LK1. 相似文献
7.
E. Isometsa M. Heikkinen M. Henriksson M. Marttunen H. Aro J. Lonnqvist 《Acta psychiatrica Scandinavica》1997,95(4):297-305
As part of a nation-wide psychological autopsy we examined the differences in DSM-III-R mental disorders, recent life events and other characteristics between urban (n=143) and rural (n=85) completed suicides in a random sample of 229 cases from the National Suicide Prevention Project in Finland for the period 1987-1988. Psychoactive substance use disorders (48% vs. 34%), cluster B personality disorders (24% vs. 9%) and psychiatric comorbidity (66% vs. 42%) were found more commonly among urban than rural suicides. Urban suicides were also more often reported to be preceded by a recent separation (25% vs. 8%), whereas rural suicide victims tended to have lacked a close companion of the opposite sex (36% vs. 18%) and to have had physical disorders (56% vs. 40%). Overall, urban and rural suicides may vary with regard to the prevalence of some mental disorders, their comorbidity, and physical disorders, as well as the preceding life situation. This variation may also imply the need for differences in strategies for suicide prevention in each setting. 相似文献
8.
In a clinical series the accuracy of standard colloid scintigraphy and gray-scale ultrasonography in investigations for liver disease was evaluated. The results of 246 investigations in which both methods were utilized were reviewed and classified according to diagnosis and follow-up. In focal disease the sensitivity was 0.90 for scintigraphy, and 0.83 for ultrasonography; ultrasonography had the higher specificity, 0.94 compared with 0.77 for scintigraphy. In diffuse disease the sensitivity was found to be low for both methods, about 0.60, while specificity was high, 0.86 for scintigraphy and 0.92 for ultrasonography. Decreased liver function in diffuse liver disease as reflected by bone marrow uptake at scintigraphy was not found to have any influence on the degree of sensitivity of ultrasonography. 相似文献
9.
Case report: Fatal hepatic failure after aortic valve replacement and sevoflurane exposure 总被引:1,自引:0,他引:1
Andreas Lehmann Michael Neher Arndt-Holger Kiessling Frank Isgro Anette Koloska Joachim Boldt 《Journal canadien d'anesthésie》2007,54(11):917-921
PURPOSE: To report a case of lethal hepatotoxicity possibly caused by sevoflurane. CLINICAL FEATURES: A 76-yr-old woman with a history of four previous minor surgical procedures developed acute liver failure after general anesthesia with sevoflurane, sufentanil and propofol for aortic valve replacement. After an uneventful procedure the patient was extubated 4.5 hr after surgery. On the second postoperative day, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increased. On the third postoperative day liver failure occurred, ALT peaked at 10504 UxL(-1) and AST at 15516 UxL(-1), and coagulopathy with an international normalized ratio of 4.6 developed. Liver transplantation was considered but rejected as a therapeutic option. The patient died three days after the operation in multiple organ failure triggered by hepatic failure. Other possible causes for liver failure were excluded. CONCLUSIONS: Sevoflurane hepatitis as a cause for liver failure may be implicated in this patient undergoing valve surgery. Unlike other halogenated anesthetic drugs, sevoflurane is not metabolized to hepatotoxic trifluoroacetyl proteins. However, compound A may react with proteins and may be transformed into antigenic material. We suggest that all halogenated anesthetics may be implicated with acute liver injury. 相似文献
10.